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Clinical outcomes for intracoronary imaging strategies at different medical facilities in Japanese patients with coronary artery disease: the SAKURA imaging PCI Registry

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Abstract

The relationships between intracoronary imaging modalities and outcomes among Japanese patients with coronary artery disease (CAD) based on the type of medical facility providing outpatient care remain unclear. In this multicenter prospective study (SAKURA PCI Registry), we aimed to investigate the clinical outcomes of patients with CAD who underwent percutaneous coronary intervention (PCI) between April 2015 and December 2018. In this registry, we investigated differences in patient characteristics, intracoronary imaging modalities, and clinical outcomes between two types of medical facilities. Of the 414 patients enrolled in this registry, 196 were treated at two university hospitals, and 218 were treated at five community hospitals (median follow-up 11.0 months). The primary endpoint was clinically relevant events (CREs), including a composite of all-cause death, non-fatal myocardial infarction, clinically driven target lesion revascularization, stent thrombosis, stroke, and major bleeding. Patients treated at university hospitals had higher rates of diabetes (50% vs. 38%, p = 0.015) and malignant tumors (12% vs. 6%, p = 0.015) and more frequent use of multiple intracoronary imaging modalities than patients treated at community hospitals (21% vs. 0.5%, p < 0.001). The Kaplan–Meier incidence of CREs at 1 year was comparable between university hospitals and community hospitals (8.8% vs. 7.3%, p = 0.527, log-rank test). Despite the relatively higher risk among patients in university hospitals with frequent use of multi-intracoronary imaging modalities, adverse clinical events appeared to be comparable between patients with CAD treated at university and community hospitals in Japan.

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Acknowledgements

The authors would like to thank all centers that participated in the study and all patients who consented to participate.

Funding

The study was funded by Daiichi Sankyo Co., Ltd.

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Authors and Affiliations

  1. Department of Medicine, Division of Cardiology, Nihon University Itabashi Hospital, Nihon University School of Medicine, Ohyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan

    Nobuhiro Murata, Daisuke Fukamachi & Yasuo Okumura

  2. Department of Cardiology, Nihon University Hospital, Tokyo, Japan

    Naoya Matsumoto

  3. Kawaguchi Municipal Medical Center, Saitama, Japan

    Eizo Tachibana

  4. Yokohama Chuo Hospital, Kanagawa, Japan

    Koji Oiwa & Michiaki Matsumoto

  5. Sekishindo Hospital, Saitama, Japan

    Toshiaki Kojima & Makoto Ichikawa

  6. Tokyo Rinkai Hospital, Tokyo, Japan

    Kazumiki Nomoto

  7. Kasukabe Municipal Hospital, Saitama, Japan

    Ken Arima

Authors
  1. Nobuhiro Murata
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  2. Daisuke Fukamachi
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  10. Ken Arima
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  11. Yasuo Okumura
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Corresponding author

Correspondence to Yasuo Okumura.

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Conflict of interest

Dr. Okumura accepted remuneration from Daiichi Sankyo and belongs to the endowed departments of Boston Scientific Japan, Abbott Medical Japan, Japan Lifeline, Medtronic Japan, and Nihon Kohden. Dr. Matsumoto received research funding from Daiichi Sankyo, Otsuka Pharmaceutical, and Sumitomo Dainippon Pharma, and accepted remuneration from Nihon Medi-Physics, FUJIFILM RI Pharma, and Biosensors Interventional Technologies Japan.

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Murata, N., Fukamachi, D., Matsumoto, N. et al. Clinical outcomes for intracoronary imaging strategies at different medical facilities in Japanese patients with coronary artery disease: the SAKURA imaging PCI Registry. Heart Vessels 37, 12–21 (2022). https://doi.org/10.1007/s00380-021-01896-x

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