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Predictors of abnormality in thallium myocardial perfusion scans for type 2 diabetes

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Abstract

Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), with data obtained from 368 male and 428 female participants with T2DM. Multiple linear regression results were as follows. In male participants, body mass index (BMI) and creatinine (Cr) were associated with SSS (β = 0.224, p < 0.001; β = 0.140, p = 0.022, respectively), and only BMI was associated with SDS (β = 0.174, p = 0.004). In female participants, BMI and high-density lipoprotein cholesterol level were associated with SSS (β = 0.240, p < 0.001; β =  − 0.120, p = 0.048, respectively), and only BMI was correlated with SDS (β = 0.123, p = 0.031). Our multivariate logistic regression indicated that in male and female participants, BMI was the only independent indicator of high SSS (SSS ≥ 9). In this study, we demonstrated that male patients have a higher SSS and SDS than female patients do in Th-201 scans for T2DM in a Chinese population. For male and female patients, BMI was the strongest predictor of abnormality in Th-201 scans. Our results can help clinicians identify patients with T2DM at high risk of CAD.

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Acknowledgements

The authors thank all participants in this study. This manuscript was edited by Wallace Academic Editing.

Funding

The work was supported by a Grant from Cardinal Tien Hospital (CTH106A-2B10).

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Author notes

  1. Chieh-Hua Lu and Dee Pei have contributed equally to the study.

Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical School, Taipei, Taiwan, ROC

    Chieh-Hua Lu

  2. Department of Internal Medicine, Fu-Jen Catholic Hospital, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan, ROC

    Dee Pei

  3. Division of Endocrinology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, ROC

    Chung-Ze Wu & Jiunn-Diann Lin

  4. Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC

    Chung-Ze Wu & Jiunn-Diann Lin

  5. Department and Institute of Life Science, Fu-Jen Catholic University, Taipei, Taiwan, ROC

    Hui-Chun Kua & Yao-Jen Liang

  6. Department of Pathology, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan, ROC

    Yen-Lin Chen

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  1. Chieh-Hua Lu
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Contributions

LC-H analyzed the data. LJ-D wrote the manuscript. WC-Z and CY-L reviewed and edited the manuscript. PD contributed to the discussion and edited the manuscript. LC-H and LY-J assisted with the data analysis and contributed to the discussion.

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Correspondence to Jiunn-Diann Lin.

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Lu, CH., Pei, D., Wu, CZ. et al. Predictors of abnormality in thallium myocardial perfusion scans for type 2 diabetes. Heart Vessels 36, 180–188 (2021). https://doi.org/10.1007/s00380-020-01681-2

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