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Clinical profiles and outcomes in the treatment of acute myocardial infarction in Japan of aging society

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To address many uncertainties in the acute care of patients with acute myocardial infarction (AMI) in proportion to increasing age, we underwent the nationwide current survey consisted of 11,676 patients with AMI based on the database of the Japanese Acute Myocardial Infarction Registry between January 2011 and December 2013 to figure out how difference of clinical profiles and outcomes between coronary revascularization and conservative treatments for AMI. Clinical profiles in a total of 763 patients with AMI with conservative treatments (7% of all) were characterized as more elderly women (median age, 71 yeas vs. 68 years, p < 0.0001, male, 71% vs. 76%, p = 0.0008), high Killip class (Killip class I, 61% vs. 75%, p < 0.0001), and non-ST-segment elevation AMI (37% vs. 27%, p < 0.0001) as compared with 10,913 with coronary revascularization, with a consequence of more than twofold higher in-hospital mortality (12% vs. 5%, p < 0.0001). When compared with conservative treatments, highly effective of coronary revascularization to decrease in-hospital mortality was found in patients with ST-segment elevation AMI (6% vs. 16%, p < 0.0001), while these advantages were not evident in those with non-ST-segment elevation AMI (4% vs. 6%, p = 0.1107), especially with high Killip class, regardless of whether or not propensity score matching of clinical characteristics. A risk-adapted allocation of invasive management therefore may have the potential of benefiting patients with non-ST-segment elevation AMI, in particular elders.

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We are sincerely appreciative of all of the JAMIR investigators mentioned below for their contributions to this study.

Sapporo ACS Network: Takashi Takenaka (Hokkaido Medical Center), Daisuke Hotta (Hokkaido Cardiovascular Hospital); Iwate ACS Registry: Tomonori Itoh (IwateMedical University School of Medicine);Yamagata AMI Registry: Tetsu Watanabe (Yamagata University School of Medicine); Miyagi AMI Registry Study: Kiyotaka Hao (Tohoku University); Jichi Medical University: Kazuomi Kario; Tokyo CCU Network: Takeshi Yamamoto (Nippon Medical School Hospital); Naoki Sato.

(Nippon Medical School Musashi-Kosugi Hospital); Atsuo Namiki (Kanto Rosai Hospital); Hiroshi Suzuki (Showa University Fujigaoka Hospital); Yokohama Cardiovascular Workshop: Masami Kosuge (Yokohama City University Medical Center); Mie ACS Registry Masaaki Ito (Mie University); Takashi Tanigawa (Matsusaka Chuo Hospital); NCVC AMI Registry: Yasuhide Asaumi (National Cerebral and Cardiovascular Center); Kumamoto Acute Coronary Events Study: Kenichi Tsujita (Kumamoto University); JAMIR data center: Yoshihiro Miyamaoto (National Cerebral and Cardiovascular Center).

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Correspondence to Makoto Suzuki.

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Suzuki, M., Nishihira, K., Takegami, M. et al. Clinical profiles and outcomes in the treatment of acute myocardial infarction in Japan of aging society. Heart Vessels 35, 1681–1688 (2020).

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