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Diagnostic performance of coronary angiography utilizing intraprocedural 320-row computed tomography with minimal contrast medium

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Abstract

Recently developed coronary angiography with intraprocedural 320-row computed tomography can be performed in a catheterization laboratory (XACT) by injecting contrast medium from a place close to the coronary arteries, thereby requiring a minimal amount of contrast medium. However, its clinical application has not yet been established. This study aimed to evaluate the diagnostic accuracy of XACT angiography with a minimal volume of contrast medium in patients with suspected coronary artery disease (CAD). A total of 167 coronary segments were analyzed in 14 patients (9 males, median age 70 years) with suspected CAD by XACT angiography with 7.5 ml of contrast medium and invasive coronary angiography (ICA) with standard techniques. The segmental-based diagnostic accuracy of XACT angiography in detecting stenosis of ≥ 50% and ≥ 75% and visualized by ICA was good (sensitivity: 74% and 62%, specificity: 99% and 99%, positive predictive value: 93% and 80%, and negative predictive value: 97% and 97%, respectively). These results suggest that XACT angiography with a very low amount of contrast medium may have strong clinical utility for screening coronary arteries in patients with renal dysfunction or undergoing clinical procedures such as pacemaker implantation.

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Acknowledgements

The authors are grateful to Yasuhiro Yanagawa for his technical assistance. We would like to thank Editage (http://www.editage.com) for English language editing.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan

    Misato Chimura, Tomohito Ohtani, Kensuke Yokoi, Tatsuya Shiraki, Themistoklis Katsimichas, Isamu Mizote, Shungo Hikoso & Yasushi Sakata

  2. 1st Cardiology Department, Athens Medical School, Hippokration General Hospital, Athens, Greece

    Themistoklis Katsimichas

  3. Minoh City Hospital, Minoh, Japan

    Takashi Kitao

  4. Monbetsu General Hospital, Monbetsu, Japan

    Masaki Awata

  5. Department of Cardiology for International Education and Research, Osaka University Graduate School of Medicine, Suita, Japan

    Satoru Sumitsuji

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  1. Misato Chimura
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  2. Tomohito Ohtani
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  3. Kensuke Yokoi
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  4. Tatsuya Shiraki
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  8. Isamu Mizote
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  11. Yasushi Sakata
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Correspondence to Tomohito Ohtani.

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All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Chimura, M., Ohtani, T., Yokoi, K. et al. Diagnostic performance of coronary angiography utilizing intraprocedural 320-row computed tomography with minimal contrast medium. Heart Vessels 35, 1341–1348 (2020). https://doi.org/10.1007/s00380-020-01610-3

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  • DOI: https://doi.org/10.1007/s00380-020-01610-3

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