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A significance of school screening electrocardiogram in the patients with ventricular noncompaction

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Abstract

Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy and is associated with high morbidity and mortality. However, the role and significance of school screening for LVNC have not been fully elucidated. In this multicenter, retrospective cohort study, a total of 105 children with LVNC were included from 2000 to 2017. At the initial presentation, 44 patients (41.9%) were diagnosed by school screening. One (1.0%) patient underwent heart transplantation and four (3.8%) patients died during the study. Electrocardiogram data showed a high prevalence of fragmented QRS (33.4%) and J wave (15.7%). Treatments were needed in eight (18.2%) patients who were detected by school screening. The multivariable proportional hazards model showed T-wave abnormality on electrocardiogram in first graders was independent risk factors for major adverse cardiac events (odds ratio 4.94, p value = 0.0007). Moreover, dilation of the left atrium on chest X-ray and low ejection fraction on echocardiogram at the initial treatment were independent risk factors for treatment (odds ratio 1.7 × 107 and 22.3, p = 0.0362 and 0.0028, respectively). This study is the first report focusing on school screening in a large pediatric cohort with LVNC. With the use of abnormalities in electrocardiogram, school screening may be a good detector of and predictor for LVNC.

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Abbreviations

LVNC:

Left ventricular noncompaction

ECG:

Electrocardiogram

MACE:

Major adverse cardiac event

LV:

Left ventricle

AUC:

Area under curve

CI:

Confidence interval

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Acknowledgements

The authors wish to acknowledge to Hitoshi Moriuchi, Haruna Hirai and Eriko Masuda for their expert technical assistance. The authors gratefully thank Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, and Sayaka Ozawa for their great assistance.

Funding

This study was partly supported by Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan (H26-002, H29-034).

Author information

Authors and Affiliations

  1. Department of Pediatrics, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama city, Toyama, 930-0194, Japan

    Keiichi Hirono & Nariaki Miyao

  2. Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan

    Masao Yoshinaga

  3. Department of Pediatric Cardiology and Neonatology, Ogaki Municipal Hospital, Ogaki, Japan

    Eiki Nishihara

  4. Department of Cardiology, Aichi Children’s Health and Medical Center, Obu, Japan

    Kazushi Yasuda

  5. Department of Pediatrics, Chiba Cardiovascular Center, Ichihara, Japan

    Shigeru Tateno

  6. Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan

    Mamoru Ayusawa

  7. Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Saitama, Japan

    Naokata Sumitomo

  8. Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Hitoshi Horigome

  9. Department of Pediatrics, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan

    Mari Iwamoto

  10. National Institute of Public Health, Wako, Japan

    Hideto Takahashi

  11. Department of Pediatric Cardiology, Okinawa Prefectural Nanbu Medical Center and Childrens Medical Center, Okinawa, Japan

    Seiichi Sato

  12. Department of Pediatrics, Osaka General Medical Center, Osaka, Japan

    Shigetoyo Kogaki

  13. Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center, Osaka, Japan

    Seiko Ohno

  14. Department of Pediatrics, School of Medicine, Fujita Health University, Toyoake, Japan

    Tadayoshi Hata

  15. Department of Pediatrics, Kagoshima University, Kagoshima, Japan

    Daisuke Hazeki

  16. Pediatric Cardiology, Akebonocho Clinic, Tokyo, Japan

    Naomi Izumida

  17. Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan

    Masami Nagashima & Nobuo Tauchi

  18. Department of Pediatrics, Kanazawa University, Kanazawa, Japan

    Kunio Ohta

  19. Pediatric Cardiology, Ohori Children’s Clinic, Fukuoka, Japan

    Hiroya Ushinohama

  20. Department of Pediatrics, Perinatal and Maternal Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

    Shozaburo Doi

  21. International University of Health and Welfare, Tokyo, Japan

    Fukiko Ichida

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  1. Keiichi Hirono
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Study group on childhood cardiomyopathy in Japan

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Correspondence to Keiichi Hirono.

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Hirono, K., Miyao, N., Yoshinaga, M. et al. A significance of school screening electrocardiogram in the patients with ventricular noncompaction. Heart Vessels 35, 985–995 (2020). https://doi.org/10.1007/s00380-020-01571-7

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