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Angles between the aortic root and the left ventricle assessed by MDCT are associated with the risk of aortic regurgitation after transcatheter aortic valve replacement

Abstract

Objectives

To evaluate the impact of the angles quantified by multidetector computed tomography (MDCT) between the ascending aorta’s long axis and, the left ventricular inflow long axis (LVLA), or the left ventricule outflow tract long axis, and the occurrence of post-transcatheter aortic valve replacement (TAVR) aortic regurgitation (AR).

Methods

We prospectively included 136 consecutive patients who underwent a transfemoral TAVR with a preoperative MDCT. The groups were defined according to AR <2 or ≥2 assessed by echocardiography at 1 month.

Results

AR ≥2 identified in 21 patients (15.4%), was associated with increased rates of mortality (p value 0.02) and heart failure (p value 0.001) at 1-year follow-up. The aorta–LVLA angle was significantly higher in patients with AR ≥2 (130.5° ± 8.8° vs. 124.6° ± 9.5°; p = 0.009). On univariate analysis, aorta–LVLA angle was predictive of AR ≥2 [OR 1.07 per degree (1.02–1.13); p = 0.011]. After adjustment on annular calcification extent, the percentage of prosthesis-annular mismatch and the type of prosthesis, the relationship between aorta–LVLA angle and the risk of AR ≥2 remained unchanged.

Conclusions

We showed that increased angulation between the ascending aorta and the LVLA is associated with higher rates of AR post-TAVR independent of other potential correlates.

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Correspondence to Vincent Roule.

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Conflict of interest

This study was performed without specific funding and there is no conflict of interest.

Ethical approval

This study has been approved by the ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all individual participants included in the study.

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Roule, V., Placente, A., Sabatier, R. et al. Angles between the aortic root and the left ventricle assessed by MDCT are associated with the risk of aortic regurgitation after transcatheter aortic valve replacement. Heart Vessels 33, 58–65 (2018). https://doi.org/10.1007/s00380-017-1032-1

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Keywords

  • Aortic regurgitation
  • Aortic valve implantation
  • Computed tomography
  • Angulation
  • Mortality