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The usefulness of brachial-ankle pulse wave velocity in predicting long-term cardiovascular events in younger patients

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Abstract

Brachial-ankle pulse wave velocity (baPWV) is known as a significant predictor of cardiovascular events. However, the previous studies have not considered age, which can affect the baPWV value. We evaluated the predictive value of baPWV for cardiovascular events in various age groups. From January 2005 to December 2012, all patients admitted to our department with any cardiovascular disease and underwent ankle-brachial index (ABI) measurement were enrolled in the IMPACT-ABI registry. The primary endpoints included major adverse cardiovascular events (MACE; cardiovascular death, myocardial infarction, and stroke). Of the 3131 patients enrolled, 2554 were included in the analysis, whereas 577 were excluded due to missing baPWV data, ABI ≤0.9 and/or >1.4, and the previous endovascular therapy and/or surgical treatment for peripheral artery disease. Patients were divided according to age 30–59 years (n = 580), 60–69 years (n = 730), 70–79 years (n = 862), and ≥80 years (n = 330). The cumulative incidence of MACE through 5 year was significantly higher in the high baPWV group (>1644 cm/s) than in the low baPWV group (≤1644 cm/s; 8.7 vs. 4.6%; log-rank: p < 0.001). However, among the age groups, only the 30–59-year group showed a significant difference in MACE incidence between those with high and low baPWV (7.0 vs. 0.9%; log-rank: p = 0.001). In conclusion, the baPWV could serve as a useful marker to predict cardiovascular events, particularly among younger patients.

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References

  1. O’Rourke M (1990) Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension. Hypertension 15:339–347

    Article  PubMed  Google Scholar 

  2. Lehmann ED (1999) Clinical value of aortic pulse-wave velocity measurement. Lancet 354:528–529

    Article  CAS  PubMed  Google Scholar 

  3. Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy BI (1995) Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 26:485–490

    Article  CAS  PubMed  Google Scholar 

  4. Sunbul M, Seckin D, Durmus E, Ozgen Z, Bozbay M, Bozbay A, Kivrak T, Oguz M, Sari I, Ergun T, Agirbasli M (2015) Assessment of arterial stiffness and cardiovascular hemodynamics by oscillometric method in psoriasis patients with normal cardiac functions. Heart Vessels 30:347–354

    Article  PubMed  Google Scholar 

  5. Blacher J, Asmar R, Djane S, London GM, Safar ME (1999) Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 33:1111–1117

    Article  CAS  PubMed  Google Scholar 

  6. van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, Hoeks AP, van der Kuip DA, Hofman A, Witteman JC (2001) Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 32:454–460

    Article  PubMed  Google Scholar 

  7. Munakata M (2014) Brachial-ankle pulse wave velocity in the measurement of arterial stiffness: recent evidence and clinical applications. Curr Hypertens Rev 10:49–57

    Article  PubMed  Google Scholar 

  8. Ki YJ, Choi DH, Lee YM, Lim L, Song H, Koh YY (2014) Predictive value of brachial-ankle pulse wave velocity for long-term clinical outcomes after percutaneous coronary intervention in a Korean cohort. Int J Cardiol 175:554–559

    Article  PubMed  Google Scholar 

  9. Han JY, Choi DH, Choi SW, Kim BB, Ki YJ, Chung JW, Koh YY, Chang KS, Hong SP (2013) Predictive value of brachial-ankle pulse wave velocity for cardiovascular events. Am J Med Sci 346:92–97

    Article  PubMed  Google Scholar 

  10. Tomiyama H, Koji Y, Yambe M, Shiina K, Motobe K, Yamada J, Shido N, Tanaka N, Chikamori T, Yamashina A (2005) Brachial-ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome. Circ J 69:815–822

    Article  PubMed  Google Scholar 

  11. Kitahara T, Ono K, Tsuchida A, Kawai H, Shinohara M, Ishii Y, Koyanagi H, Noguchi T, Matsumoto T, Sekihara T, Watanabe Y, Kanai H, Ishida H, Nojima Y (2005) Impact of brachial-ankle pulse wave velocity and ankle-brachial blood pressure index on mortality in hemodialysis patients. Am J Kidney Dis 46:688–696

    Article  PubMed  Google Scholar 

  12. Kawai T, Ohishi M, Onishi M, Ito N, Takeya Y, Oguro R, Takami Y, Yamamoto K, Rakugi H (2015) Prognostic impact of regional arterial stiffness in hypertensive patients. Heart Vessels 30:338–346

    Article  PubMed  Google Scholar 

  13. Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S (2003) Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement-a survey of 12517 subjects. Atherosclerosis 166:303–309

    Article  CAS  PubMed  Google Scholar 

  14. Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y (2002) Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 25:359–364

    Article  PubMed  Google Scholar 

  15. Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, Kaul S, Wiviott SD, Menon V, Nikolsky E, Serebruany V, Valgimigli M, Vranckx P, Taggart D, Sabik JF, Cutlip DE, Krucoff MW, Ohman EM, Steg PG, White H (2011) Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation 123:2736–2747

    Article  PubMed  Google Scholar 

  16. McKee PA, Castelli WP, McNamara PM, Kannel WB (1971) The natural history of congestive heart failure: the Framingham study. N Engl J Med 285:1441–1446

    Article  CAS  PubMed  Google Scholar 

  17. Yamashina A, Tomiyama H, Arai T, Koji Y, Yambe M, Motobe H, Glunizia Z, Yamamoto Y, Hori S (2003) Nomogram of the relation of brachial-ankle pulse wave velocity with blood pressure. Hypertens Res 26:801–806

    Article  PubMed  Google Scholar 

  18. Tanaka H, Dinenno FA, Monahan KD, DeSouza CA, Seals DR (2001) Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men. Arterioscler Thromb Vasc Biol 21:82–87

    Article  CAS  PubMed  Google Scholar 

  19. Tracy RE (2001) Medial thickenings of coronary artery and the aging risk factor for atherosclerosis. Atherosclerosis 155:337–346

    Article  CAS  PubMed  Google Scholar 

  20. Cohn JN (2001) Arterial compliance to stratify cardiovascular risk: more precision in therapeutic decision making. Am J Hypertens 14:258s–263s

    Article  CAS  PubMed  Google Scholar 

  21. Ohnishi H, Saitoh S, Takagi S, Ohata J, Isobe T, Kikuchi Y, Takeuchi H, Shimamoto K (2003) Pulse wave velocity as an indicator of atherosclerosis in impaired fasting glucose: the Tanno and Sobetsu study. Diabetes Care 26:437–440

    Article  PubMed  Google Scholar 

  22. Ohya Y, Iseki K, Iseki C, Miyagi T, Kinjo K, Takishita S (2006) Increased pulse wave velocity is associated with low creatinine clearance and proteinuria in a screened cohort. Am J Kidney Dis 47:790–797

    Article  CAS  PubMed  Google Scholar 

  23. Newman AB, Siscovick DS, Manolio TA, Polak J, Fried LP, Borhani NO, Wolfson SK (1993) Ankle-arm index as a marker of atherosclerosis in the Cardiovascular Health Study. Cardiovascular Heart Study (CHS) Collaborative Research Group. Circulation 88:837–845

    Article  CAS  PubMed  Google Scholar 

  24. Diehm C, Allenberg JR, Pittrow D, Mahn M, Tepohl G, Haberl RL, Darius H, Burghaus I, Trampisch HJ (2009) Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease. Circulation 120:2053–2061

    Article  PubMed  Google Scholar 

  25. Motobe K, Tomiyama H, Koji Y, Yambe M, Gulinisa Z, Arai T, Ichihashi H, Nagae T, Ishimaru S, Yamashina A (2005) Cut-off value of the ankle-brachial pressure index at which the accuracy of brachial-ankle pulse wave velocity measurement is diminished. Circ J 69:55–60

    Article  PubMed  Google Scholar 

  26. Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, Wautrecht JC, Kornitzer M, Newman AB, Cushman M, Sutton-Tyrrell K, Fowkes FG, Lee AJ, Price JF, d’Agostino RB, Murabito JM, Norman PE, Jamrozik K, Curb JD, Masaki KH, Rodriguez BL, Dekker JM, Bouter LM, Heine RJ, Nijpels G, Stehouwer CD, Ferrucci L, McDermott MM, Stoffers HE, Hooi JD, Knottnerus JA, Ogren M, Hedblad B, Witteman JC, Breteler MM, Hunink MG, Hofman A, Criqui MH, Langer RD, Fronek A, Hiatt WR, Hamman R, Resnick HE, Guralnik J, McDermott MM (2008) Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA 300:197–208

    Article  CAS  PubMed  Google Scholar 

  27. Tartiere JM, Logeart D, Safar ME, Cohen-Solal A (2006) Interaction between pulse wave velocity, augmentation index, pulse pressure and left ventricular function in chronic heart failure. J Hum Hypertens 20:213–219

    Article  PubMed  Google Scholar 

  28. Ninomiya T, Kojima I, Doi Y, Fukuhara M, Hirakawa Y, Hata J, Kitazono T, Kiyohara Y (2013) Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study. J Hypertens 31:477–483

    Article  CAS  PubMed  Google Scholar 

  29. Park KH, Kim MK, Kim HS, Park WJ, Cho GY, Choi YJ (2011) Clinical significance of framingham risk score, flow-mediated dilation and pulse wave velocity in patients with stable angina. Circ J 75:1177–1183

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Yasushi Ueki, Takashi Miura, Masatoshi Minamisawa, Naoyuki Abe, Hitoshi Nishimura, Naoto Hashizume, Tomoaki Mochidome, Mikiko Harada, Kunihiko Shimizu, Yasutaka Oguchi, Kouji Yoshie, Wataru Shoin, Souichiro Ebisawa, Hirohiko Motoki, Jun Koyama & Uichi Ikeda

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  1. Yasushi Ueki
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  2. Takashi Miura
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  3. Masatoshi Minamisawa
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  4. Naoyuki Abe
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Correspondence to Yasushi Ueki.

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The study is registered at the clinical trials registration http://www.umin.ac.jp/ctr/index/htm/ (UMIN000020276).

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Ueki, Y., Miura, T., Minamisawa, M. et al. The usefulness of brachial-ankle pulse wave velocity in predicting long-term cardiovascular events in younger patients. Heart Vessels 32, 660–667 (2017). https://doi.org/10.1007/s00380-016-0919-6

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  • DOI: https://doi.org/10.1007/s00380-016-0919-6

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