Abstract
Very late stent thrombosis (VLST) is a serious complication after percutaneous coronary intervention. However, the best therapy for VLST with late-acquired incomplete stent apposition and incomplete neointimal coverage remains unknown. In these cases, neointimal coverage was nearly complete and no late-acquired malapposition was detected at 18 months after Endeavor zotarolimus-eluting stent (ZES) implantation for the treatment of VLST with late-acquired incomplete stent apposition after sirolimus-eluting stent implantation. We presented that Endeavor ZES implantation may become an attractive therapeutic strategy for the treatment of VLST with late-acquired incomplete stent apposition and incomplete neointimal coverage.
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Stone GW, Moses JW, Ellis SG, Schofer J, Dawkins KD, Morice MC, Colombo A, Schampaert E, Grube E, Kirtane AJ, Cutlip DE, Fahy M, Pocock SJ, Mehran R, Leon MB (2007) Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents. N Engl J Med 356:998–1008
Yamawaki M, Onuma Y, Nakano M, Muramatsu T, Nakatani S, Ishibashi Y, Ishimori H, Hirano K, Ito Y, Tsukahara R, Muramatsu T (2014) Simultaneous occlusion of left anterior descending and left circumflex arteries by very late stent thrombosis: vascular response to drug-eluting stents assessed by intravascular ultrasound. Heart Vessels. doi:10.1007/s00380-014-0545-0
Mahmoud KD, Vlaar PJ, van den Heuvel AF, Hillege HL, Zijlstra F, de Smet BJ (2011) Usefulness of thrombus aspiration for the treatment of coronary stent thrombosis. Am J Cardiol 108:1721–1727
Nasuno T, Tokura M, Kageyama M, Toyoda S, Sakuma M, Komatsu T, Taguchi I, Abe S, Inoue T (2015) The wound healing response after implantation of a drug-eluting stent is impaired persistently in the long term. Heart Vessels. doi:10.1007/s00380-015-0676-y
Fajadet J, Wijns W, Laarman GJ, Kuck KH, Ormiston J, Münzel T, Popma JJ, Fitzgerald PJ, Bonan R, Kuntz RE, Investigators ENDEAVORII (2006) Randomized, double-blind, multicenter study of the Endeavor zotarolimus-eluting phosphorylcholine-encapsulated stent for treatment of native coronary artery lesions: clinical and angiographic results of the ENDEAVOR II trial. Circulation 114:798–806
Kim JS, Jang IK, Fan C, Kim TH, Kim JS, Park SM, Choi EY, Lee SH, Ko YG, Choi D, Hong MK, Jang Y (2009) Evaluation in 3 months duration of neointimal coverage after zotarolimus-eluting stent implamtation by optical coherence tomography: the ENDEAVOR OCT trial. JACC Cardiovasc Interv 2:1240–1247
Basalus MW, Ankone MJ, van Houwelingen GK, de Man FH, von Birgelen C (2009) Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy. Euro Interv 5:157–165
von Birgelen C, Basalus MW (2010) On the loss of the phosphorylcholine-based DES coating on the abluminal surface of Endeavor stents. Catheter Cardiovasc Interv 76:158–159
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Online Video 1. IVUS image shows positive remodeling and late-acquired incomplete stent apposition at the site of SES implantation. (MPG 1947 kb)
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Online Video 2. IVUS image shows full neointimal proliferation in the ZES, which was implanted in the SES site with positive remodeling. (MPG 2208 kb)
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Online Video 3. IVUS shows positive remodeling and late-acquired incomplete stent apposition with thrombus at the site of the SES implantation. (MPG 2097 kb)
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Kakefuda, Y., Sato, A., Watabe, H. et al. Efficacy of Endeavor zotarolimus-eluting stent implantation for the treatment of very late stent thrombosis with late-acquired incomplete stent apposition after sirolimus-eluting stent implantation. Heart Vessels 31, 1196–1199 (2016). https://doi.org/10.1007/s00380-015-0720-y
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DOI: https://doi.org/10.1007/s00380-015-0720-y