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Association between smoking habits and severity of coronary stenosis as assessed by coronary computed tomography angiography

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Abstract

Smoking promotes arteriosclerosis and is one of the most important coronary risk factors. However, few studies have investigated the association between smoking habits and the severity of coronary stenosis as assessed by coronary computed tomography angiography (CTA). We enrolled 416 patients [165/251 = smoker (past and current)/non-smoker)]. They had all undergone CTA and either were clinically suspected of having coronary artery disease (CAD) or had at least one cardiovascular risk factor. We divided the patients into smoking and non-smoking groups, and evaluated the presence of CAD, the number of significantly stenosed coronary vessels (VD), and the Gensini score as assessed by CTA in the two groups. The incidence of CAD, VD, the Gensini score, and coronary calcification score in the smoking group were all significantly greater than those in the non-smoking group (CAD, p = 0.009; VD, p = 0.003; Gensini score, p = 0.007; coronary calcification score, p = 0.01). Pack-year was significantly associated with VD and the Gensini score, and was strongly associated with multi-vessel disease (2- and 3-VD) (p < 0.05), whereas the duration of cessation in past smokers was not associated with VD or the Gensini score. Pack-year, but not the duration of cessation, may be the most important factor that was associated with the severity of coronary stenosis in terms of VD and the Gensini score.

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Authors and Affiliations

  1. Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan

    Masaya Yano, Shin-ichiro Miura, Yuhei Shiga, Yuiko Miyase, Yasunori Suematsu, Kenji Norimatsu, Ayumi Nakamura, Sen Adachi, Hiroaki Nishikawa & Keijiro Saku

  2. Department of Molecular Cardiovascular Therapeutics, Fukuoka University School of Medicine, Fukuoka, Japan

    Shin-ichiro Miura & Keijiro Saku

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  1. Masaya Yano
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  2. Shin-ichiro Miura
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  3. Yuhei Shiga
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  4. Yuiko Miyase
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  5. Yasunori Suematsu
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Correspondence to Shin-ichiro Miura.

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Conflict of interest

K. S. is a Chief Director and S. M. is a Director of NPO Clinical and Applied Science, Fukuoka, Japan. K. S. has an Endowed “Department of Molecular Cardiovascular Therapeutics” supported by MSD, Co. LTD. S. M. belongs to the Department of Molecular Cardiovascular Therapeutics, which is supported by MSD, Co. LTD.

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Yano, M., Miura, Si., Shiga, Y. et al. Association between smoking habits and severity of coronary stenosis as assessed by coronary computed tomography angiography. Heart Vessels 31, 1061–1068 (2016). https://doi.org/10.1007/s00380-015-0716-7

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  • DOI: https://doi.org/10.1007/s00380-015-0716-7

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