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Usefulness of serum bilirubin levels as a biomarker for long-term clinical outcomes after percutaneous coronary intervention

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Abstract

The aim of this study was to evaluate the prognostic value of serum total bilirubin on the development of adverse outcomes after percutaneous coronary intervention (PCI) besides high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP). Serum total bilirubin, hs-cTnT, and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary endpoint was cardiac death. There were 21 events of cardiac death during a mean of 25.8 months of follow-up. When the serum total bilirubin cut-off level (median value) was set to 0.58 mg/dL using the receiver operating characteristic curve, the sensitivity was 95.2 % and the specificity was 51.0 % for differentiating between the group with cardiac death and the group without cardiac death. Kaplan–Meier analysis revealed that the lower serum total bilirubin group (<0.58 mg/dL) had a significantly higher cardiac death rate than the higher serum total bilirubin group (≥0.58 mg/dL) (10.4 vs. 0.6 %, log-rank: P = 0.0001). In conclusion, low serum total bilirubin is a predictive marker for cardiac death after PCI.

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Acknowledgments

This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2013011486 and 20120006836).

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Authors and Affiliations

  1. Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea

    Hyun-Wook Kim, Dong-Hyun Choi, Young-Min Lee, Young-Jae Ki & Young-Youp Koh

  2. Department of Biomaterials, Chosun University Graduate School, Gwangju, 501-759, Republic of Korea

    Leejin Lim

  3. Department of Internal Medicine, Mokpo Jung-ang General Hospital, Mokpo, Republic of Korea

    Joon Tae Kang & Seung Seok Chae

  4. Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju, 501-759, Republic of Korea

    Heesang Song

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  1. Hyun-Wook Kim
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  2. Dong-Hyun Choi
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  4. Young-Min Lee
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  9. Young-Youp Koh
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Correspondence to Dong-Hyun Choi.

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Supplementary material 1 (JPG 32 kb)

The ROC curve for serum total bilirubin, peak hs-cTnT and NT-proBNP to predict cardiac death

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Kim, HW., Choi, DH., Lim, L. et al. Usefulness of serum bilirubin levels as a biomarker for long-term clinical outcomes after percutaneous coronary intervention. Heart Vessels 30, 728–733 (2015). https://doi.org/10.1007/s00380-014-0546-z

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  • DOI: https://doi.org/10.1007/s00380-014-0546-z

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