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Resolution of acromegalic cardiomyopathy in mild acromegalic physical abnormality after short-term octreotide therapy

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Abstract

Congestive heart failure developed in a 42-year-old man who had very mild acromegalic features. Echocardiography showed a marked dilatation of the left ventricle and decreased systolic function. Laboratory examinations revealed the elevated levels of growth hormone and insulin-like growth factor-1 and pituitary microadenoma was demonstrated by magnetic resonance imaging. Although the extensive conventional medical treatment was ineffective, short-term addition of somatostatin analog, octreotide, rapidly improved his cardiac function. After discontinuation of octreotide, further improvement was observed with minimal residual diastolic dysfunction. All medical treatment could be stopped after successful trans-sphenoidal surgery. Early diagnosis and effective treatment is important to reverse the acromegalic cardiomyopathy.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Ijinkai-Takeda General Hospital, 28-1 Ishidamori, Minami-machi, Fushimi-ku, Kyoto, 601-1495, Japan

    Myung-Woo Hwang, Yoshio Sasaki, Hiroyuki Ayukawa, Katsura Inenaga, Rei Takeoka, Tomoyuki Iwase & Chuichi Kawai

  2. Clinical Research Institute, Center for Endocrine and Metabolic Diseases, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan

    Akira Shimatsu

Authors
  1. Myung-Woo Hwang
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  2. Akira Shimatsu
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  3. Yoshio Sasaki
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  4. Hiroyuki Ayukawa
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  5. Katsura Inenaga
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  6. Rei Takeoka
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  7. Tomoyuki Iwase
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  8. Chuichi Kawai
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Correspondence to Chuichi Kawai.

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Hwang, MW., Shimatsu, A., Sasaki, Y. et al. Resolution of acromegalic cardiomyopathy in mild acromegalic physical abnormality after short-term octreotide therapy. Heart Vessels 22, 202–207 (2007). https://doi.org/10.1007/s00380-006-0960-y

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  • DOI: https://doi.org/10.1007/s00380-006-0960-y

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