Abstract
HMG-CoA reductase inhibitors (statins) have been shown to improve the endothelial function by lowering lipids. Recent studies also suggest a direct impact of statins on the vascular wall. We assessed the rapid effect of cerivastatin on the coronary flow velocity reserve (CFVR) using transthoracic Doppler echocardiography (TTDE). The coronary flow velocity from the distal left anterior descending artery was measured in 16 healthy subjects (all male, age 24–38 years) using a 5-MHz transducer, on the day before, just before, and 3 h after administering 0.3 mg of cerivastatin. Hyperemia was achieved by the intravenous administration of adenosine, and the CFVR was calculated as the radio of the mean diastolic hyperemic coronary flow velocity to the basal flow velocity. The serum lipid profile and high-sensitivity C-reactive protein (hsCRP) were measured. The CFVR following the single administration of cerivastatin increased from 2.93 ± 0.58 to 3.91 ± 0.86, P = 0.003, and was significantly higher than the CFVR measured at the same time on the previous day (3.91 ± 0.86 vs 3.37 ± 0.48, P = 0.009). Neither the serum lipid profile nor hsCRP exhibited a remarkable change after cerivastatin administration. We concluded that a single-dose administration of cerivastatin, an HMG-CoA reductase inhibitor, improves the coronary flow velocity reserve without modifying the serum lipid profile.
Similar content being viewed by others
References
FM Sacks AM Tonkin J Shepherd E Braunwald S Cobbe CM Hawkins A Keech C Packard J Simes R Byington CD Furberg (2000) ArticleTitleEffect of pravastatin on coronary disease events in subgroups defined by coronary risk factors: the Prospective Pravastatin Pooling Project Circulation 102 1893–1900 Occurrence Handle1:CAS:528:DC%2BD3cXnvV2qtL0%3D Occurrence Handle11034935
GG Schwartz AG Olsson MD Ezekowitz P Ganz MF Oliver D Waters A Zeiher BR Chaitman S Leslie T Stem (2001) ArticleTitleEffects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial JAMA 285 1711–1718 Occurrence Handle10.1001/jama.285.13.1711 Occurrence Handle1:CAS:528:DC%2BD3MXivFGnurc%3D Occurrence Handle11277825
J Dupuis JC Tardif P Cernacek P Theroux (1999) ArticleTitleCholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial Circulation 99 3227–3233 Occurrence Handle1:CAS:528:DyaK1MXksVaqu7o%3D Occurrence Handle10385495
S John C Delles J Jacobi MP Schlaich M Schneider G Schmitz RE Schmieder (2001) ArticleTitleRapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks J Am Coll Cardiol 37 1351–1358 Occurrence Handle10.1016/S0735-1097(01)01128-7 Occurrence Handle1:CAS:528:DC%2BD3MXjtl2ju7c%3D Occurrence Handle11300446
WH Leung CP Lau CK Wong (1993) ArticleTitleBeneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients Lancet 341 1496–1500 Occurrence Handle10.1016/0140-6736(93)90634-S Occurrence Handle1:STN:280:DyaK3s3otVyqsw%3D%3D Occurrence Handle8099379
T Hozumi K Yoshida T Akasaka Y Asami Y Ogata T Takagi S Kaji T Kawamoto Y Ueda S Morioka (1998) ArticleTitleNoninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique J Am Coll Cardiol 32 1251–1259 Occurrence Handle10.1016/S0735-1097(98)00389-1 Occurrence Handle1:STN:280:DyaK1M%2FisFyjtw%3D%3D Occurrence Handle9809933
K Fujimoto T Hozumi H Watanabe K Shimada M Takeuchi Y Sakanoue N Shimizu R Otsuka Y Kawase K Sakamoto M Yoshiyama Y Baba K Haze J Yoshikawa (2004) ArticleTitleEffect of fluvastatin therapy on coronary flow reserve in patients with hypercholesterolemia Am J Cardiol 93 1419–1421 Occurrence Handle10.1016/j.amjcard.2004.02.046 Occurrence Handle1:CAS:528:DC%2BD2cXksVGgs7k%3D Occurrence Handle15165930
V Pasceri JT Willerson ET Yeh (2000) ArticleTitleDirect proinflammatory effect of C-reactive protein on human endothelial cells Circulation 102 2165–2168 Occurrence Handle1:CAS:528:DC%2BD3cXptVSjtbk%3D Occurrence Handle11056086
PM Ridker N Rifai SP Lowenthal (2001) ArticleTitleRapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia Circulation 103 1191–1193 Occurrence Handle1:CAS:528:DC%2BD3MXisFeksL0%3D Occurrence Handle11238259
H Omori H Nagashima Y Tsurumi A Takagi N Ishizuka N Hagiwara M Kawana H Kasanuki (2002) ArticleTitleDirect in vivo evidence of a vascular statin: a single dose of cerivastatin rapidly increases vascular endothelial responsiveness in healthy normocholesterolaemic subjects Br J Clin Pharmacol 54 395–399 Occurrence Handle10.1046/j.1365-2125.2002.01677.x Occurrence Handle1:CAS:528:DC%2BD38XpsVWitLw%3D Occurrence Handle12392587
HV Anderson MJ Stokes M Leon SA Abu-Halawa Y Stuart RL Kirkeeide (2000) ArticleTitleCoronary artery flow velocity is related to lumen area and regional left ventricular mass Circulation 102 48–54 Occurrence Handle1:STN:280:DC%2BD3czkt1ymug%3D%3D Occurrence Handle10880414
K Sudhir JS MacGregor SD Barbant E Foster PJ Fitzgerald K Chatterjee PG Yock (1993) ArticleTitleAssessment of coronary conductance and resistance vessel reactivity in response to nitroglycerin, ergonovine and adenosine: in vivo studies with simultaneous intravascular two-dimensional and Doppler ultrasound J Am Coll Cardiol 21 1261–1268 Occurrence Handle1:CAS:528:DyaK3sXks1alurw%3D Occurrence Handle8459086 Occurrence Handle10.1016/0735-1097(93)90255-Y
TJ Anderson A Uehata MD Gerhard IT Meredith S Knab D Delagrange EH Lieberman P Ganz MA Creager AC Yeung (1995) ArticleTitleClose relation of endothelial function in the human coronary and peripheral circulations J Am Coll Cardiol 26 1235–1241 Occurrence Handle10.1016/0735-1097(95)00327-4 Occurrence Handle1:STN:280:DyaK28%2Fjtlykug%3D%3D Occurrence Handle7594037
AH Wagner T Kohler U Ruckschloss I Just M Hecker (2000) ArticleTitleImprovement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation Arterioscler Thromb Vasc Biol 20 61–69 Occurrence Handle1:CAS:528:DC%2BD3cXmvFylsw%3D%3D Occurrence Handle10634801
T Matsuo K Iwade N Hirata M Yamashita H Ikegami N Tanaka M Aosaki H Kasanuki (2005) ArticleTitleImprovement of arterial stiffness by the antioxidant and anti-inflammatory effects of short-term statin therapy in patients with hypercholesterolemia Heart Vessels 20 8–12 Occurrence Handle10.1007/s00380-004-0793-5 Occurrence Handle15700196
U Laufs V La Fata J Plutzky JK Liao (1998) ArticleTitleUpregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors Circulation 97 1129–1135 Occurrence Handle1:CAS:528:DyaK1cXisVWmsrY%3D Occurrence Handle9537338
A Brouet P Sonveaux C Dessy S Moniotte JL Balligand O Feron (2001) ArticleTitleHsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins Circ Res 89 866–873 Occurrence Handle1:CAS:528:DC%2BD3MXos1aqtrw%3D Occurrence Handle11701613
E Saunders K Ferdinand LG Yellen MJ Tonkon S Krug-Gourley M Poland (2000) ArticleTitleEfficacy and safety of cerivastatin and pravastatin in the treatment of primary hypercholesterolemia J Natl Med Assoc 92 319–326 Occurrence Handle1:STN:280:DC%2BD3cvjvVCqtg%3D%3D Occurrence Handle10946527
B Pitt D Waters WV Brown AJ van Boven L Schwartz LM Title D Eisenberg L Shurzinske LS McCǐmick (1999) ArticleTitleAggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus Revascularization Treatment Investigators N Engl J Med 341 70–76 Occurrence Handle10.1056/NEJM199907083410202 Occurrence Handle1:CAS:528:DyaK1MXks1Glsb4%3D Occurrence Handle10395630
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Takagi, A., Tsurumi, Y., Ishizuka, N. et al. Single administration of cerivastatin, an HMG-CoA reductase inhibitor, improves the coronary flow velocity reserve: a transthoracic Doppler echocardiography study. Heart Vessels 21, 298–301 (2006). https://doi.org/10.1007/s00380-006-0905-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00380-006-0905-5