Skip to main content
Log in

Diagnostic value of 16-slice multidetector computed tomography in symptomatic patients with suspected significant obstructive coronary artery disease

  • Published:
Heart and Vessels Aims and scope Submit manuscript


We investigated the diagnostic value and limitations of 16-slice multidetector computed tomography (MDCT) to detect significant obstructive coronary artery disease in symptomatic patients. A total of 43 symptomatic patients underwent conventional coronary angiography and 16-slice multidetector computed tomography for the detection of significant obstructive coronary artery disease. The diagnostic value and limitations of 16-slice multidetector computed tomography to detect significant coronary stenoses were determined by analyzing all coronary arteries and proximal segments, both including and excluding unevaluable segments. Analysis of all 592 coronary artery segments demonstrated moderate sensitivity (67%) and positive predictive value (69%), with a high specificity (95%) and negative predictive value (94%) for the detection of significant coronary artery stenoses. When the unevaluable segments had been excluded, with the analysis of all evaluable segments, proximal segments, and evaluable proximal segments, sensitivity increased (71%, 77%, and 83%, respectively), and high specificity (95%, 96%, and 96%, respectively) and negative predictive value (95%) were maintained. When we repeated the analysis taking only the patients into account, 16-slice MDCT correctly diagnosed 88% of all patients but a moderate negative predictive value (63%) was obtained. Artifacts caused by cardiac motion were the most frequent reason for unevaluable segments. Calcification was the leading cause of degraded image quality and incorrect diagnosis. Our results demonstrated that 16-slice MDCT has a moderate diagnostic value for the correct diagnosis of symptomatic patients with significant coronary artery disease. This result suggests that 16-slice MDCT may not be able to exclude significant coronary artery disease reliably in patients at high risk.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. S Achenbach T Giesler D Ropers S Ulzheimer H Derlien C Schulte E Wenkel W Moshage W Bautz WG Daniel WA Kalender U Baum (2001) ArticleTitleDetection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography Circulation 103 2535–2538 Occurrence Handle1:STN:280:DC%2BD3M3pvFaisg%3D%3D Occurrence Handle11382719

    CAS  PubMed  Google Scholar 

  2. K Nieman M Oudkerk BJ Rensing P van Ooijen A Munne RJ van Geuns PJ de Feyter (2001) ArticleTitleCoronary angiography with multi-slice tomography Lancet 357 559–603 Occurrence Handle10.1016/S0140-6736(00)04058-7

    Article  Google Scholar 

  3. A Knez CR Becker A Leber B Ohnesorge A Becker C White R Haberl MF Reiser G Steinbeck (2001) ArticleTitleUsefulness of multislice spiral computed tomography angiography for determination of coronary artery stenoses Am J Cardiol 88 1191–1194 Occurrence Handle10.1016/S0002-9149(01)02060-4 Occurrence Handle1:STN:280:DC%2BD3MnltF2ktg%3D%3D Occurrence Handle11703970

    Article  CAS  PubMed  Google Scholar 

  4. A Knez CR Becker A Leber B Ohnesorge A Becker C White R Haberl MF Reiser G Steinbeck (2002) ArticleTitleUsefulness of multislice spiral computed tomography for detecting obstructive coronary artery disease Am J Cardiol 89 913–918 Occurrence Handle10.1016/S0002-9149(02)02238-5

    Article  Google Scholar 

  5. K Nieman BJ Rensing RJ van Geuns J Vos PM Pattynama GP Krestin PW Serruys PJ de Feyter (2002) ArticleTitleNon-invasive coronary angiography with multislice spiral CT: the impact on heart rate Heart 88 470–474 Occurrence Handle10.1136/heart.88.5.470 Occurrence Handle1:STN:280:DC%2BD38nisVWntg%3D%3D Occurrence Handle12381635

    Article  CAS  PubMed  Google Scholar 

  6. K Nieman F Cademartiri PA Lemos R Raaijmakers PM Pattynama PJ De Feyter (2002) ArticleTitleReliable noninvasive coronary angiography with fast submillimeter multislice spiral computed tomography Circulation 106 2051–2054 Occurrence Handle10.1161/01.CIR.0000037222.58317.3D Occurrence Handle12379572

    Article  PubMed  Google Scholar 

  7. D Ropers U Baum K Pohle K Anders S Ulzheimer B Ohnesorge C Schlundt W Bautz WG Daniel S Achenbach (2003) ArticleTitleDetection of coronary artery stenoses with thin-slice multidetector row spiral computed tomography and multiplanar reconstruction Circulation 107 664–666 Occurrence Handle10.1161/01.CIR.0000055738.31551.A9 Occurrence Handle12578863

    Article  PubMed  Google Scholar 

  8. A Kuettner T Beck T Drosch K Kettering M Heuschmid C Burgstahler CD Claussen AF Kopp S Schroeder (2005) ArticleTitleDiagnostic accuracy of noninvasive coronary angiography imaging using 16-detector slice spiral computed tomography with 188 ms temporal resolution J Am Coll Cardiol 45 123–127 Occurrence Handle10.1016/j.jacc.2004.10.050 Occurrence Handle15629385

    Article  PubMed  Google Scholar 

  9. Y Sato N Matsumo F Inoue T Imazeki J Kusama T Tamaki S Furuhashi M Takahashi H Kanamaru K Karasawa M Ayusawa K Harada K Kanmatsuse (2004) ArticleTitleAssessment of 11 coronary artery abnormalities in a patient with Kawasaki disease by multislice computed tomography Heart Vessels 19 IssueID6 297–299 Occurrence Handle10.1007/s00380-003-0758-0 Occurrence Handle15799178

    Article  PubMed  Google Scholar 

  10. Y Sato F Inoue A Yoshimura T Fukui T Imazeki M Kato H Ono S Yoda M Mitsui N Matsumoto S Furuhashi M Takahashi K Kanmatsuse (2003) ArticleTitleRegression of an atherosclerotic coronary artery plaque demonstrated by multislice spiral computed tomography in a patient with stable angina pectoris Heart Vessels 18 IssueID4 224–226 Occurrence Handle10.1007/s00380-003-0712-1 Occurrence Handle14520493

    Article  PubMed  Google Scholar 

  11. U Hoffmann F Moselewski RC Cury M Ferencik IK Jang LJ Diaz S Abbara TJ Brady S Achenbach (2004) ArticleTitlePredictive value of 16-slice multidetector spiral computed tomography to detect significant obstructive coronary artery disease in patients at high risk for coronary artery disease Circulation 110 2638–2643 Occurrence Handle10.1161/01.CIR.0000145614.07427.9F Occurrence Handle15492297

    Article  PubMed  Google Scholar 

  12. A Kuettner T Trabold S Schroeder A Feyer T Beck A Brueckner M Heuschmid C Burgstahler AF Kopp CD Claussen (2004) ArticleTitleNoninvasive detection of coronary lesions using 16-detector multislice spiral computed tomography technology: initial clinical results J Am Coll Cardiol 44 1230–1237 Occurrence Handle15364324

    PubMed  Google Scholar 

  13. WG Austen JE Edwards RL Frye GG Gensini VL Gott LS Griffith DC McGoon ML Murphy BB Roe (1975) ArticleTitleA reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association Circulation 51 IssueIDSuppl 4 5–40 Occurrence Handle1:STN:280:DyaE2M7htFersg%3D%3D Occurrence Handle1116248

    CAS  PubMed  Google Scholar 

  14. A Kuettner AF Kopp S Schroeder T Rieger J Brunn C Meisner M Heuschmid T Trabold C Burgstahler J Martensen W Schoebel HK Selbmann CD Claussen (2004) ArticleTitleDiagnostic accuracy of multidetector computed tomography coronary angiography in patients with angiographically proven coronary artery disease J Am Coll Cardiol 43 831–839 Occurrence Handle10.1016/j.jacc.2003.05.015 Occurrence Handle14998625

    Article  PubMed  Google Scholar 

  15. JY Moon N Chung BW Choi KO Choe HS Seo YG Ko SM Kang JW Ha SJ Rim Y Jang WH Shim SY Cho (2005) ArticleTitleUtility of multidetector row spiral CT for detection of coronary artery stenoses Yonsei Med J 46 IssueID1 86–94 Occurrence Handle15744810 Occurrence Handle10.3349/ymj.2005.46.1.86

    Article  PubMed  Google Scholar 

  16. C Gaudio F Mirabelli L Alessandra BL Nguyen S Di Michele F Corsi G Tanzilli M Mancone G Pannarale M Francone I Carbone C Catalano R Passariello F Fedele (2005) ArticleTitleNoninvasive assessment of coronary artery stenoses by multidetector-row spiral computed tomography: comparison with conventional angiography Eur Rev Med Pharmacol Sci 9 IssueID1 13–21 Occurrence Handle1:STN:280:DC%2BD2M3hsFKmtA%3D%3D Occurrence Handle15850140

    CAS  PubMed  Google Scholar 

  17. T Beck A Kuettner C Burgstahler A Bruckner M Heuschmid C Herdeg AF Kopp CD Claussen S Schroeder (2004) ArticleTitleNoninvasive detection of coronary stenosis using 16-slice detector computed tomography in carefully selected patients Med Klin 99 IssueID11 645–650 Occurrence Handle10.1007/s00063-004-1095-5

    Article  Google Scholar 

  18. SS Shim Y Kim SM Lim (2005) ArticleTitleImprovement of image quality with beta-blocker premedication on ECG-gated 16-MDCT coronary angiography Am J Roentgenol 184 IssueID2 649–654

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Nihan Erdogan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Erdogan, N., Akar, N., Vural, M. et al. Diagnostic value of 16-slice multidetector computed tomography in symptomatic patients with suspected significant obstructive coronary artery disease. Heart Vessels 21, 278–284 (2006).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

Key words