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Effects of electrical stimulation of the medullary raphe nuclei on respiratory movement in rats

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An Erratum to this article was published on 28 February 2006

Abstract

The present study was undertaken to examine the effects of electrical stimulation of the medullary raphe nuclei on respiration in rats anesthetized with ketamine and xylazine. Train pulse stimuli (100 Hz, 10–30 μA) were applied in the regions of the caudal raphe nuclei: the raphe magnus (RM), raphe pallidus (RP) and raphe obscurus (RO). Stimulation of the RM depressed inspiratory movements measured by means of an abdominal pneumograph, whereas stimulation of the RP augmented inspiratory movements. It was revealed that stimulation of the RO induced either inhibitory or facilitatory effects on respiratory movements depending on the stimulation sites. These findings confirm and extend previous studies concerning the effects of raphe stimulation on respiratory activity in cats. The present results demonstrate that in rats the caudal raphe nuclei are involved in respiratory control.

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Acknowledgements

This study was in part supported by a grant from the Sapporo Medical University Foundation for Promotion of Medical Science.

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Author notes

  1. Ying Cao

    Present address: Institute of Physiology, Shandong University School of Medicine, Jinan, P. R. China

Authors and Affiliations

  1. Department of Physiology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo-ku, Sapporo, 060-8556, Japan

    Ying Cao, Yutaka Fujito, Kiyoji Matsuyama & Mamoru Aoki

Authors
  1. Ying Cao
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  2. Yutaka Fujito
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  3. Kiyoji Matsuyama
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  4. Mamoru Aoki
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Corresponding author

Correspondence to Yutaka Fujito.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00359-006-0113-x

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Cao, Y., Fujito, Y., Matsuyama, K. et al. Effects of electrical stimulation of the medullary raphe nuclei on respiratory movement in rats. J Comp Physiol A 192, 497–505 (2006). https://doi.org/10.1007/s00359-005-0087-0

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  • DOI: https://doi.org/10.1007/s00359-005-0087-0

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