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Investigating the haemodynamics of myocardial bridging

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Abstract

Myocardial bridging is a congenital anomaly wherein a segment of a coronary artery passes under a ‘bridge’ of heart muscle rather than resting upon the heart’s surface. Although it is usually benign, myocardial bridging has been associated with adverse clinical events including ischaemia, arrhythmia and sudden death. Moreover, there is a tendency for atherosclerotic lesions to develop upstream of the bridge. These lesions may be the result of adverse fluid dynamic phenomena induced by the periodic compression of the artery by the overlying myocardial bridge. It is not possible to visualise these phenomena in vivo, and in this study we present an in vitro model capable of replicating the bridging conditions. This model is comprised of a pressure-measuring guide wire and catheter, a piston pump, a scaled artery model, and a ‘myocardial bridging mechanism’ which periodically compresses the artery model. A proportional-integral-derivative (PID) controller allowed the piston pump to recreate a patient-specific aortic pressure waveform upstream of the occluded artery model segment for each study. Stationary occlusions—achieved by placing 3D printed ‘stenosis inserts’ within the artery model—induced globally reduced pressures downstream of the stenosis when compared against the upstream pressure waveform. Conversely, the pressures downstream of the dynamic stenoses generated by the bridging mechanism closely matched the upstream pressures at all stages of the cardiac cycle except at the end of systole. This divergent pressure behaviour at the end of systole was similarly observed in vivo within a patient with a myocardial bridge. Flow visualisation using a laser sheet enabled dynamic flow structures to be observed, including recirculating flow regions, which may be precursors to arterial dysfunction.

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Acknowledgements

We would like to extend our gratitude to all of the technical staff at UNSW Sydney who were involved in the design and manufacture of the experimental model, particularly Stephen Kuhle, Vincenzo Carnevale, Mark Baldry and Martyn Sherriff. Thank you, also, to Ashkan Javadzadegan and Abouzar Moshfegh for their help with the patient data processing and collection. Finally, our gratitude to the patient, without whom the experimental model could not have been validated.

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Authors and Affiliations

  1. UNSW Sydney, Sydney, Australia

    P. R. S. Vijayaratnam, D. Fulker, Y. C. Kim, J. Brandt, J. Yi, A. Simmons & T. J. Barber

  2. Department of Cardiology, Concord Hospital, The University of Sydney, Sydney, Australia

    A. S. C. Yong & L. Kritharides

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  1. P. R. S. Vijayaratnam
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  2. D. Fulker
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  3. Y. C. Kim
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Correspondence to P. R. S. Vijayaratnam.

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Vijayaratnam, P.R.S., Fulker, D., Kim, Y.C. et al. Investigating the haemodynamics of myocardial bridging. Exp Fluids 62, 86 (2021). https://doi.org/10.1007/s00348-021-03185-9

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