Experiments in Fluids

, 57:110

A biomimetic bi-leaflet mitral prosthesis with enhanced physiological left ventricular swirl restorative capability

Research Article

DOI: 10.1007/s00348-016-2195-8

Cite this article as:
Tan, S.GD., Kim, S. & Leo, H.L. Exp Fluids (2016) 57: 110. doi:10.1007/s00348-016-2195-8


Mechanical heart valve prostheses are often implanted in young patients due to their durability and long-term reliability. However, existing designs are known to induce elevated levels of blood damage and blood platelet activation. As a result, there is a need for patients to undergo chronic anti-coagulation treatment to prevent thrombosis, often resulting in bleeding complications. Furthermore, recent studies have suggested that the implantation of a mechanical prosthetic valve at the mitral position results in a significant alteration of the left ventricular flow field which may contribute to flow turbulence. This study proposes a bi-leaflet mechanical heart valve design (Bio-MHV) that mimics the geometry of a human mitral valve, with the aim of reducing turbulence levels in the left ventricle by replicating physiological flow patterns. An in vitro three-dimensional particle velocimetry imaging experiment was carried out to compare the hemodynamic performance of the Bio-MHV with that of the clinically established ATS valve. The Bio-MHV was found to replicate physiological left ventricular flow patterns and produced lower turbulence levels.

Funding information

Funder NameGrant NumberFunding Note
Agency for Science, Technology and Research

    Copyright information

    © Springer-Verlag Berlin Heidelberg 2016

    Authors and Affiliations

    • Sean Guo-Dong Tan
      • 1
    • Sangho Kim
      • 1
    • Hwa Liang Leo
      • 1
    1. 1.Department of Biomedical Engineering, Faculty of EngineeringNational University of SingaporeSingaporeSingapore

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