Experiments in Fluids

, 57:110 | Cite as

A biomimetic bi-leaflet mitral prosthesis with enhanced physiological left ventricular swirl restorative capability

  • Sean Guo-Dong Tan
  • Sangho Kim
  • Hwa Liang Leo
Research Article


Mechanical heart valve prostheses are often implanted in young patients due to their durability and long-term reliability. However, existing designs are known to induce elevated levels of blood damage and blood platelet activation. As a result, there is a need for patients to undergo chronic anti-coagulation treatment to prevent thrombosis, often resulting in bleeding complications. Furthermore, recent studies have suggested that the implantation of a mechanical prosthetic valve at the mitral position results in a significant alteration of the left ventricular flow field which may contribute to flow turbulence. This study proposes a bi-leaflet mechanical heart valve design (Bio-MHV) that mimics the geometry of a human mitral valve, with the aim of reducing turbulence levels in the left ventricle by replicating physiological flow patterns. An in vitro three-dimensional particle velocimetry imaging experiment was carried out to compare the hemodynamic performance of the Bio-MHV with that of the clinically established ATS valve. The Bio-MHV was found to replicate physiological left ventricular flow patterns and produced lower turbulence levels.


Particle Image Velocimetry Inverse Distance Weighting Mechanical Heart Valve Valve Design Kolmogorov Length Scale 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We gratefully acknowledge the support of a grant from Biomedical Engineering Programme, Agency of Science, Technology and Research Singapore for this study. The authors thank Dr. Boyang Su and Dr. Foad Kabinejadian for their contribution and advice.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Sean Guo-Dong Tan
    • 1
  • Sangho Kim
    • 1
  • Hwa Liang Leo
    • 1
  1. 1.Department of Biomedical Engineering, Faculty of EngineeringNational University of SingaporeSingaporeSingapore

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