Skip to main content
SpringerLink
Log in

Intra-aneurysmal blood flow based on patient-specific CT angiogram

  • Research Article
  • Published:
Experiments in Fluids Aims and scope Submit manuscript

Abstract

To discuss the validity of the hemodynamic hypothesis of aneurysm rupture, we used a patient-specific, realistic aneurysm model to reveal the flow structure and wall shear stress distribution in two cases: one with an unruptured aneurysm and the other with a ruptured aneurysm. We used particle imaging velocimetry and laser Doppler velocimetry to measure velocity profiles of intra-aneurysmal flow. Both cases had a circulating flow along the aneurysm wall, although the second case had a recirculating zone only in the minimum phase. Differences in the wall shear stress profile may identify aneurysm rupture.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  • Adrian RJ (1986) Image shifting technique to resolve directional ambiguity in double-pulsed velocimetry. Appl Opt 25:3855–3858

    Article  Google Scholar 

  • Adrian RJ (1997) Dynamic ranges of velocity and spatial resolution of particle image velocimetry. Meas Sci Technol 8:1393–1398

    Article  Google Scholar 

  • Creasy JK, Crump DB, Knox L, Kerber CW, Price RR (1995) Design and evaluation of a flow phantom. Acad Radiol 2:902–904

    Article  Google Scholar 

  • Crompton MR (1966) Mechanism of growth and rupture in cerebral berry aneurysms. Brit Med J 1:1138–1142

    Article  Google Scholar 

  • Davis P (1995) Flow-mediated endothelial mechanotransduction. Physiol Rev 75:519–560

    Google Scholar 

  • Ford MD, Nikolov HN, Milner JS, Lownie SP, Demont EM, Kalata W, Loth F, Holdsworth DW, Steinman DA (2008) PIV-measured versus CFD-predicted flow dynamics in anatomically realistic cerebral aneurysm models. J Biomech Eng 130:021015

    Article  Google Scholar 

  • Foutrakis GN, Yonas H, Sclabassi RJ (1999) Saccular aneurysm formation in curved and bifurcating arteries. Am J Neuroradiol 20:1309–1317

    Google Scholar 

  • Gobin YP, Counord JL, Flaud P, Duffaux J (1994) In vitro study of haemodynamics in a giant saccular aneurysm model: Influence of flow dynamics in the parent vessel and effects of coil embolization. Neuroradiology 36:530–536

    Article  Google Scholar 

  • Hashimoto N, Handa H, Nagata I, Hazama F (1980) Experimentally induced cerebral aneurysms in rats: Part V. Relation of hemodynamics in the circle of Willis to formation of aneurysms. Surg Neurol 13:41–45

    Google Scholar 

  • Hassler O (1972) Scanning electron microscopy of saccular intracranial aneurysms. Am J Pathol 68:511–519

    Google Scholar 

  • Hennerici M, Rautenberg W, Sitzer G, Schwartz A (1987) Transcranial Doppler ultrasound for the assessment of intracranial arterial flow velocity Part 1. Surg Neurol 27:439–448

    Article  Google Scholar 

  • Hopkins LM, Kelly JT, Wexler AS, Prasad AK (2000) Particle image velocity measurements in complex geometries. Exp Fluids 29:91–95

    Article  Google Scholar 

  • International Study of Unruptured Intracranial Aneurysms Investigators (2003) Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362:103–110

    Article  Google Scholar 

  • Johnston SC, Gress DR, Kahn JG (1999) Which unruptured cerebral aneurysms should be treated? a cost-utility analysis. Neurology 52:1806–1815

    Google Scholar 

  • Juvela S, Porras M, Heiskanen O (1993) Natural history of unruptured intracranial aneurysms: a long-term follow-up study. J Neurosurg 79:174–182

    Article  Google Scholar 

  • Kayembe KNT, Sasahara M, Hazama F (1984) Cerebral aneurysms and variations of the circle of Willis. Stroke 15:846–850

    Google Scholar 

  • Kim SK, Chung SK (2004) An investigation on airflow in disordered nasal cavity and its corrected models by tomographic PIV. Meas Sci Technol 15:1090–1096

    Article  MathSciNet  Google Scholar 

  • Ku DN, Giddens DP, Zarins CK, Glagov S (1985) Pulsatile flow and atherosclerosis in the human carotid bifurcation. Atherosclerosis 5:293–302

    Google Scholar 

  • Liou TM, Chang WC, Liao CC (1997) Experimental study of steady and pulsatile flows in cerebral aneurysm model of various sizes at branching site. J Biomech Engr 119:325–332

    Article  Google Scholar 

  • Massoud TF, Hademenos GJ, Young WL, Gao E, Pile-Spellman J, Vinuela F (1998) Principles and philosophy of modeling in biomedical research. FASEB J 12:275–285

    Google Scholar 

  • Roach MR, Scott S, Ferguson GG (1972) The hemodynamic importance of the geometry of bifurcation in the circle of Willis (glass model studies). Stroke 3:255–267

    Google Scholar 

  • Sho E, Sho M, Singh TM, Nanjo H, Komatsu M, Xu C, Masuda H, Zarins CK (2002) Arterial enlargement in response to high flow requires early expression of matrix metalloproteinases to degrade extracellular matrix. Exp Mol Pathol 73:142–153

    Article  Google Scholar 

  • Shojima M, Oshima M, Takagi K, Torii R, Nagata K, Shirouzu I, Morita A, Kirino T (2005) Role of the bloodstream impacting force and the local pressure elevation in the rupture of cerebral aneurysms. Stroke 36:1933–1938

    Article  Google Scholar 

  • Stehbens WE (1989) Etiology of intracranial berry aneurysms. J Neurosurg 70:823–831

    Article  Google Scholar 

  • Stehbens WE, Liepsch DW, Poll A, Erhard W (1995) Recording of unexpectedly high frequency vibrations of blood vessel walls in experimental arteriovenous fistulae of rabbits using a laser vibrometer. Biorheology 32:631–641

    Article  Google Scholar 

  • Steiger HJ, Poll A, Liepsch D, Reulen HJ (1987) Basic flow structure in saccular aneurysms: a flow visualization study. Heart Vess 3:55–65

    Article  Google Scholar 

  • Steinman DA (2002) Image-based computational fluid dynamics modeling in realistic arterial geometries. Ann Biomed Engr 30:483–497

    Article  Google Scholar 

  • Suzuki J, Ohara H (1978) Clinicopathological study of cerebral aneurysms. J Neurosurg 48:505–514

    Article  Google Scholar 

  • Tateshima S, Murayama Y, Villablanca JP, Morino T, Takahashi H, Yamauchi T, Tanishita K, Vinuela F (2001) Intra-aneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold. J Neurosurg 95:1020–1027

    Article  Google Scholar 

  • Tateshima S, Murayama Y, Villablanca JP, Morino T, Nomura K, Tanishita K, Vinuela F (2003a) In vitro measurement of fluid-induced wall shear stress in unruptured cerebral aneurysms harboring blebs. Stroke 34:187–192

    Article  Google Scholar 

  • Tateshima S, Vinueka F, Villablanca JP, Murayama Y, Morino T, Nomura K, Tanishita K (2003b) Three-dimensional blood flow analysis in a wide-necked internal carotid artery-ophthalmic artery aneurysm. J Neurosurg 99:526–533

    Article  Google Scholar 

  • Tateshima S, Grinstead J, Sinha S, Nien Y, Murayama Y, Villablanca JP, Tanishita K, Vinuela F (2004) Intra-aneurysmal flow visualization by phase contrast magnetic resonance imaging: feasibility in vitro study using a geometrically realistic aneurysm model. J Neurosurg 100:1041–1048

    Article  Google Scholar 

  • Tateshima S, Tanishita K, Omura H, Villablanca JP, Vinuela F (2007) Intra-aneurysmal hemodynamics during the growth of an unruptured aneurysm: in vitro study using longitudinal CT angiogram database. Am J Neuroradiol 28:622–627

    Google Scholar 

  • Tateshima S, Tanishita K, Vinuela F (2008) Hemodynamics and cerebrovascular disease. Surg Neurol 70:447–453

    Article  Google Scholar 

  • Tognetti F, Limoni P, Testa C (1983) Aneurysm growth and hemodynamic stress. Surg Neurol 20:74–78

    Article  Google Scholar 

  • Tremmel M, Dhar S, Levy EI, Mocco J, Meng H (2009) Influence of intracranial aneurysm-to-parent vessel size ratio on hemodynamics and implication for rupture: results from a virtual experimental study. Neurosurgery 64:622–631

    Article  Google Scholar 

  • Tsutsumi K, Ueki K, Morita A et al (2000) Risk of rupture from incidental cerebral aneurysms. J Neurosurg 93:550–553

    Article  Google Scholar 

  • Ujiie H, Tachibana H, Hiramatsu O, Hazel AL, Matsumoto T, Ogasawara Y, Nakajima H, Hori T, Takakura K, Kajiya F (1999) Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms. Neurosurgery 45:119–129

    Article  Google Scholar 

  • Ujiie H, Tamano Y, Sasaki K, Hori T (2001) Is the aspect ratio a reliable index for predicting the rupture of a saccular aneurysm? Neurosurgery 48:495–502

    Article  Google Scholar 

  • Weir B, MacDonald RL (1996) Aneurysms and subarachnoid hemorrhage. In: Wilkins RH, Rengachary SS (eds) Neurosurgery. McGraw-Hill, New York, pp 2191–2213

    Google Scholar 

  • Wiebers DO, Whisnant JP, O’Fallon WM (1981) The natural history of unruptured intracranial aneurysms. N Engl J Med 304:696–698

    Google Scholar 

Download references

Acknowledgments

This work was partially supported by a grant-in-aid for scientific research (A 17206020) provided by the Japan Society for the Promotion of Science. The authors thank Ms. Kiyoe Nomura for helpful discussions.

Author information

Authors and Affiliations

  1. Department of System Design Engineering, Keio University, Yokohama, Japan

    Taku Morino, Tetsuya Tanoue & Kazuo Tanishita

  2. Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA

    Satoshi Tateshima & Fernando Vinuela

Authors
  1. Taku Morino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tetsuya Tanoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Satoshi Tateshima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fernando Vinuela
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kazuo Tanishita
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Taku Morino.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morino, T., Tanoue, T., Tateshima, S. et al. Intra-aneurysmal blood flow based on patient-specific CT angiogram. Exp Fluids 49, 485–496 (2010). https://doi.org/10.1007/s00348-009-0816-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00348-009-0816-1

Keywords

Search

Navigation