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Matching index of refraction using a diethyl phthalate/ethanol solution for in vitro cardiovascular models

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Abstract

Experiments studying cardiovascular geometries require a working fluid that matches the high index of refraction of glass and silicone, has a low viscosity, and is safe and inexpensive. A good candidate working fluid is diethyl phthalate (DEP), diluted with ethanol. Measurements were made of index of refraction and viscosity of varied dilutions at a range of temperatures, and empirical models are proposed. Material compatibility tests showed that only specific formulations of ABS, acrylic, vinyl and PVC are compatible. A silicone elastomer additionally tested negative for change in compliance with DEP exposure.

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References

  • Api AM (2001) Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients. Food Chem Toxicol 39:97–108

    Article  PubMed  CAS  Google Scholar 

  • Bale-Glickman J, Selby K, Saloner D, Savas O (2003) Experimental flow studies in exact-replica phantoms of atherosclerotic carotid bifurcations under steady input conditions. J Biomech Eng 125:38–48

    Article  PubMed  CAS  Google Scholar 

  • Budwig R (1994) Refractive index matching methods for liquid flow investigations. Exp Fluids 17:350–355

    Article  CAS  Google Scholar 

  • Colon I, Caro D, Bourdony C, Rosario O (2000) Identification of phthalate esters in the serum of young Puerto Rican Girls with premature breast development. Environ Health Perspect 108:895–900

    PubMed  CAS  Google Scholar 

  • Donnelly R (1981) Fluid dynamics. In: Anderson H (ed) AIP 50th anniversary physics vade mecum. American Institute of Physics, New York, pp 193–195

    Google Scholar 

  • Drexler E, Slifka A, Wright J, McCowan C, Finch D, Quinn T, McColskey J, Ivy D, Shandas R (2003) An experimental method for measuring mechanical properties of rat pulmonary arteries verified with latex. NIST J Res 108:183–191

    Google Scholar 

  • Duncan D, Bargeron C, Borchardt S, Deters O, Gearhart S, Mark F, Friedman M (1990) The effect of compliance on wall shear in casts of a human aortic bifurcation. J Biomech Eng 112:183–188

    PubMed  CAS  Google Scholar 

  • Fischer Scientific (2005) http://www.fischerscientific.com

  • Forsythe W (ed) (1954) Smithsonian physical tables, 9th edn. The Smithsonian Institution, Washington

    Google Scholar 

  • Giner J, Ibarz A, Garza S, Xhian-Quan S (1996) Rheology of clarified cheery juices. J Food Eng 30:147–154

    Article  Google Scholar 

  • Hill S, Shaw B, Wu A (2003) Plasticizers, antioxidants, and other contaminants found in air delivered by PVC tubing used in respiratory therapy. Biomed Chromatogr 17:250–262

    Article  PubMed  CAS  Google Scholar 

  • Hooper H (1992) MS Thesis, Uuniversity of Idaho, Moscow, ID

  • Lide D (ed) (2004) CRC handbook of chemistry and physics, 85th edn. CRC, New York

    Google Scholar 

  • Liu C, Vafidis C, Whitelaw J (1994) Flow characteristics of a centrifugal pump. J Fluids Eng 116:303–309

    Google Scholar 

  • Mason D, Wilcox O, Sage B (1952) Viscosities of several fluids. J Phys Chem 58:1008–1010

    Article  Google Scholar 

  • Narrow T, Yoda M, Abdel-Khalik S (2000) A simple model for the refractive index of sodium iodide aqueous solutions. Exp Fluids 28:282–283

    Article  CAS  Google Scholar 

  • Nguyen T, Biadillah Y, Mongrain R, Brunette J, Tardif J, Bertrand O (2004) A method for matching the refractive index and kinematic viscosity of a blood analog for flow visualization in hydraulic cardiovascular models. J Biomech Eng 126:529–535

    Article  PubMed  CAS  Google Scholar 

  • O’Connell P, McKenna G (1999) Arrhenius-type temperature dependence of the segmental relaxation below T g . J Chem Phys 110:11054–11060

    Article  CAS  ADS  Google Scholar 

  • Sonde V, D’souza A, Tarapore R, Pereira L, Khare MP, Sinkar P, Krishnan S, Rao CV (2000) Simultaneous administration of diethyl phthalate and ethyl alcohol and its toxicity in male Sprague- Dawley rats. Toxicol 147:23–31

    Article  CAS  Google Scholar 

  • Stoots C, Becker S, Condie K, Durst F, McEligot D (2001) A large-scale matched index of refraction flow facility for LDA studies around complex geometries. Exp Fluids 30:391–398

    Article  Google Scholar 

  • Stroll H, Durst F, Peric M, Pereira JC, Scheuerer G (1993) Study of laminar, unsteady piston-cylinder flows. J Fluids Eng 115:687–693

    Article  Google Scholar 

  • TableCurve 2D http://www.systat.com/products/TableCurve2D/

  • Thompson B, Bouchery O, Lowney K (1998) Refractive-index-matching laser velocimetry for complex, isothermal flows. J Fluids Eng 120:204–207

    Google Scholar 

  • Uzol O, Chow Y, Katz J, Meneveau C (2002) Unobstructed particle image velocimetry measurements within an axial turbo-pump using liquid and blades with matched refractive indices. Exp Fluids 33:909–919

    CAS  Google Scholar 

  • Weinberg C, Hertzberg J, Shandas R (2002) Utility of intravascular ultrasound to measure local compliance of the pediatric pulmonary artery: in vitro studies. J Am Soc Echocardiogr 15:1507–1514

    Article  PubMed  Google Scholar 

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Acknowledgements

This work is supported by NIH Grant GM066728-01. The authors would like to thank Craig Lanning for his help.

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Authors and Affiliations

  1. Department Mechanical Engineering, University of Colorado, 427 UCB, Boulder, CO, 80309, USA

    P. Miller, K. Danielson, G. Moody & J. Hertzberg

  2. National Institute of Standards and Technology, Boulder, CO, USA

    A. Slifka & E. Drexler

Authors
  1. P. Miller
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  2. K. Danielson
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  3. G. Moody
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  4. A. Slifka
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  5. E. Drexler
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  6. J. Hertzberg
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Corresponding author

Correspondence to J. Hertzberg.

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Miller, P., Danielson, K., Moody, G. et al. Matching index of refraction using a diethyl phthalate/ethanol solution for in vitro cardiovascular models. Exp Fluids 41, 375–381 (2006). https://doi.org/10.1007/s00348-006-0146-5

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  • DOI: https://doi.org/10.1007/s00348-006-0146-5

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