Skip to main content
SpringerLink
Log in

Präklinische Entwicklungen von Behandlungsmöglichkeiten für retinale Dystrophien bei der neuronalen Ceroid-Lipofuszinose

Preclinical developments of treatment options for retinal dystrophy in neuronal ceroid lipofuscinosis

  • Leserbriefe
  • Published:
Der Ophthalmologe Aims and scope Submit manuscript

The Original Article was published on 02 June 2021

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Atiskova Y, Bartsch S, Danyukova T et al (2019) Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype. Sci Rep 9:14185

    Article  Google Scholar 

  2. Bartsch S, Liu J, Bassal M et al (2021) Experimental therapeutic approaches for the treatment of retinal dystrophy in neuronal ceroid lipofuscinosis. Ophthalmologe 118:106–112

    Article  Google Scholar 

  3. Bartsch U, Galliciotti G, Jofre GF et al (2013) Apoptotic photoreceptor loss and altered expression of lysosomal proteins in the nclf mouse model of neuronal ceroid lipofuscinosis. Invest Ophthalmol Vis Sci 54:6952–6959

    Article  CAS  Google Scholar 

  4. Bassal M, Liu J, Jankowiak W et al (2021) Rapid and progressive loss of multiple retinal cell types in cathepsin D‑deficient mice-an animal model of CLN10 disease. Cells 10:696

    Article  Google Scholar 

  5. Behnke V, Langmann T (2021) Neuroinflammation in neuronal ceroid lipofuscinosis. Ophthalmologe 118:98–105

    Article  CAS  Google Scholar 

  6. Jankowiak W, Brandenstein L, Dulz S et al (2016) Retinal degeneration in mice deficient in the lysosomal membrane protein CLN7. Invest Ophthalmol Vis Sci 57:4989–4998

    Article  CAS  Google Scholar 

  7. Johnson TB, Cain JT, White KA et al (2019) Therapeutic landscape for Batten disease: current treatments and future prospects. Nat Rev Neurol 15:161–178

    Article  Google Scholar 

  8. Kohlschütter A, Schulz A, Bartsch U et al (2019) Current and emerging treatment strategies for neuronal ceroid lipofuscinoses. CNS Drugs 33:315–325

    Article  Google Scholar 

  9. Schulz A, Ajayi T, Specchio N et al (2018) Study of intraventricular cerliponase alfa for CLN2 disease. N Engl J Med 378:1898–1907

    Article  CAS  Google Scholar 

  10. Spitzer MS, Bartsch U (2021) Neuronal ceroid lipofuscinoses. Ophthalmologe 118:96–97

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Augenheilkunde, Experimentelle Ophthalmologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland

    Udo Bartsch, Junling Liu, Mahmoud Bassal, Wanda Jankowiak, Martin S. Spitzer & Susanne Bartsch

Authors
  1. Udo Bartsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Junling Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mahmoud Bassal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wanda Jankowiak
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Martin S. Spitzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Susanne Bartsch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Udo Bartsch.

Ethics declarations

Interessenkonflikt

U. Bartsch, J. Liu, M. Bassal, W. Jankowiak, M.S. Spitzer und S. Bartsch geben an, dass kein Interessenkonflikt besteht.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bartsch, U., Liu, J., Bassal, M. et al. Präklinische Entwicklungen von Behandlungsmöglichkeiten für retinale Dystrophien bei der neuronalen Ceroid-Lipofuszinose. Ophthalmologe 118, 769–770 (2021). https://doi.org/10.1007/s00347-021-01419-z

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00347-021-01419-z

Search

Navigation