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„Zuwarten“ als therapeutisches Prinzip bei Erkrankungen der vitreoretinalen Grenzfläche

Watchful waiting as a therapeutic principle for diseases of the vitreoretinal interface

  • Das therapeutische Prinzip
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Zusammenfassung

Unter den Operationen des hinteren Augenabschnitts sind mittlerweile die elektiven Eingriffe der vitreoretinalen Grenzfläche die häufigste Indikation. Im Rahmen dieser Eingriffe werden OCT (optische Kohärenztomographie)-Befunde sehr unterschiedlich interpretiert. Dieser Beitrag soll einige wichtige Aspekte und Diskrepanzen der Befundinterpretation im Zusammenhang mit der Indikationsstellung und der Nachsorge nach Vitrektomie bei vitreoretinalen Grenzflächenerkrankungen aufgreifen und anhand von Fallbeispielen diskutieren, dass auch Zuwarten eine therapeutische Option sein kann. Entscheidend ist dabei die sorgfältige Indikationsstellung, basierend auf der Symptomatik und dem Leidensdruck des Patienten und der Einordnung postoperativer bildgebender Befunde wie Netzhautverdickung und irreguläre Netzhautoberfläche nach Peelingoperation. Thematisiert wird ferner die Schwierigkeit der Differenzierung zwischen zystoidem Makulaödem nach Kataraktoperation bei gleichzeitig vorhandener epiretinaler Gliose und Gliose als Ursache des Makulaödems.

Abstract

Elective surgery of the vitreoretinal interface is currently the most common reason for vitrectomy in Germany. The evaluation and correct interpretation of spectral domain optical coherence tomography (SD-OCT) images is of great importance but the indications for vitrectomy in macular surgery should be based more on patient symptoms and not only the OCT findings. Watchful waiting is highlighted as an alternative therapeutic option in individual patients. This article addresses a number of aspects and discrepancies between findings and patients’ level of suffering based on binocular symptoms. Postoperative retinal thickening and irregular surface of the macula after peeling operations may still allow excellent function and often require no therapeutic measures. The difficulties in differentiating between cystoid macular edema after cataract operations with simultaneous epiretinal gliosis and gliosis as the cause of macular edema are highlighted.

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Literatur

  1. Brossmann J, Czerny C, Freyschmidt J, Schmidt H, Coels AD (2000) Freyschmidt’s „Köhler/Zimmer“: Grenzen des Normalen und Anfänge des Pathologischen in der Radiologie des kindlichen und erwachsenen Skeletts, 14. Aufl. Thieme, Stuttgart, S 1120

    Google Scholar 

  2. Englund M, Guermazi A, Gale D, Hunter DJ, Aliabadi P, Clancy M et al (2008) Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med 359(11):1108–1115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Modic MT (2007) Degenerative disc disease: genotyping, MR imaging and phenotyping. Skeletal Radiol 36(2):91–93

    Article  PubMed  Google Scholar 

  4. Kauffmann Y, Ramel J‑C, Isaico R, De Lazzer A, Bron AM, Creuzot-Garcher C (2017) Long-term anatomical and functional outcomes after combined cataract and idiopathic epiretinal membrane surgery. Ophthalmic Res 57(2):125–134

    Article  PubMed  Google Scholar 

  5. Kauffmann Y, Ramel J‑C, Lefebvre A, Isaico R, De Lazzer A, Bonnabel A et al (2015) Preoperative prognostic factors and predictive score in patients operated on for combined cataract and idiopathic epiretinal membrane. Am J Ophthalmol 160(1):185–192.e5

    Article  PubMed  Google Scholar 

  6. Kim HJ, Kang J‑W, Chung H, Kim HC (2014) Correlation of foveal photoreceptor integrity with visual outcome in idiopathic epiretinal membrane. Curr Eye Res 39(6):626–633

    Article  PubMed  Google Scholar 

  7. Itoh Y, Inoue M, Rii T, Hirota K, Hirakata A (2013) Correlation between foveal cone outer segment tips line and visual recovery after epiretinal membrane surgery. Invest Ophthalmol Vis Sci 54(12):7302–7308

    Article  PubMed  Google Scholar 

  8. Shimozono M, Oishi A, Hata M, Matsuki T, Ito S, Ishida K et al (2012) The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery. Am J Ophthalmol 153(4):698–704, 704.e1

    Article  PubMed  Google Scholar 

  9. Park SW, Byon IS, Kim HY, Lee JE, Oum BS (2015) Analysis of the ganglion cell layer and photoreceptor layer using optical coherence tomography after idiopathic epiretinal membrane surgery. Albrecht Von Graefes Arch Klin Exp Ophthalmol 253(2):207–214

    Article  Google Scholar 

  10. Frisina R, Pinackatt SJ, Sartore M, Monfardini A, Baldi A, Cesana BM et al (2015) Cystoid macular edema after pars plana vitrectomy for idiopathic epiretinal membrane. Albrecht Von Graefes Arch Klin Exp Ophthalmol 253(1):47–56

    Article  Google Scholar 

  11. Bouwens MD, de Jong F, Mulder P, van Meurs JC (2008) Results of macular pucker surgery: 1‑ and 5‑year follow-up. Albrecht Von Graefes Arch Klin Exp Ophthalmol 246(12):1693–1697

    Article  Google Scholar 

  12. Bartz-Schmidt K‑U, Bertram B, Bornfeld N, Bresgen M, Eter N, Feltgen N et al (2013) Current Statement of the German Ophthalmological Society, the Retina Society and the Professional Association of German Ophthalmologists for therapeutic intravitreal application of Ocriplasmin (JETREA ®) in ophthalmology (May 2013). Klin Monbl Augenheilkd 230(6):629–634

    Article  PubMed  Google Scholar 

  13. Tibbetts MD, Reichel E, Witkin AJ (2014) Vision loss after intravitreal ocriplasmin: correlation of spectral-domain optical coherence tomography and electroretinography. JAMA Ophthalmol 132(4):487–490

    Article  PubMed  Google Scholar 

  14. Dimopoulos S, Bartz-Schmidt K‑U, Gelisken F, Januschowski K, Ziemssen F (2015) Rate and timing of spontaneous resolution in a vitreomacular traction group: should the role of watchful waiting be re-evaluated as an alternative to ocriplasmin therapy? Br J Ophthalmol 99(3):350–353

    Article  PubMed  Google Scholar 

  15. Mitchell P, Smith W, Chey T, Wang JJ, Chang A (1997) Prevalence and associations of epiretinal membranes. The Blue Mountains Eye Study, Australia. Ophthalmology 104(6):1033–1040

    Article  CAS  PubMed  Google Scholar 

  16. Jahn CE, Minich V, Moldaschel S, Kron M (1999) Perioperative prevalence of epiretinal membranes in eyes with senile cataract. Klin Monbl Augenheilkd 215(4):252–254

    Article  CAS  PubMed  Google Scholar 

  17. Pearlstone AD (1985) The incidence of idiopathic preretinal macular gliosis. Ann Ophthalmol 17(6):378–380

    CAS  PubMed  Google Scholar 

  18. Creese K, Ong D, Zamir E (2012) Should macular optical coherence tomography be part of routine preoperative cataract assessment? Clin Experiment Ophthalmol 40(1):e118–e119

    Article  PubMed  Google Scholar 

  19. Milani P, Raimondi G, Morale D, Scialdone A (2012) Biomicroscopy versus optical coherence tomography screening of epiretinal membranes in patients undergoing cataract surgery. Retina 32(5):897–904

    Article  PubMed  Google Scholar 

  20. Klein BR, Brown EN, Casden RS (2016) Preoperative macular spectral-domain optical coherence tomography in patients considering advanced-technology intraocular lenses for cataract surgery. J Cataract Refract Surg 42(4):537–541

    Article  PubMed  Google Scholar 

  21. Contreras I, Noval S, Tejedor J (2008) Use of optical coherence tomography to measure prevalence of epiretinal membranes in patients referred for cataract surgery. Arch Soc Esp Oftalmol 83(2):89–94

    Article  CAS  PubMed  Google Scholar 

  22. Erdmann A, Hoerauf H (2016) Stellenwert der optischen Kohärenztomographie in der präoperativen Diagnostik funduskopisch unauffälliger Kataraktpatienten. In: Abstractband DOG-Kongress 2016, „Augenheilkunde – ein großes Fach“, Berlin. (Do13-04)

    Google Scholar 

  23. Sanisoglu H, Elbay A, Sevim S, Celik U, Aktas FB, Durmus E (2013) Surgical therapy versus observation for lamellar macular hole: a retrospective comparison study. Clin Ophthalmol 7:1843–1848

    PubMed  PubMed Central  Google Scholar 

  24. Lee CS, Koh HJ, Lim HT, Lee KS, Lee SC (2012) Prognostic factors in vitrectomy for lamellar macular hole assessed by spectral-domain optical coherence tomography. Acta Ophthalmol (Copenh) 90(8):e597–e602

    Article  Google Scholar 

  25. Bottoni F, Deiro AP, Giani A, Orini C, Cigada M, Staurenghi G (2013) The natural history of lamellar macular holes: a spectral domain optical coherence tomography study. Albrecht Von Graefes Arch Klin Exp Ophthalmol 251(2):467–475

    Article  Google Scholar 

  26. Engler C, Schaal KB, Höh AE, Dithmar S (2008) Surgical treatment of lamellar macular hole. Ophthalmologe 105(9):836–839

    Article  CAS  PubMed  Google Scholar 

  27. Fraser-Bell S, Guzowski M, Rochtchina E, Wang JJ, Mitchell P (2003) Five-year cumulative incidence and progression of epiretinal membranes: the Blue Mountains Eye Study. Ophthalmology 110(1):34–40

    Article  PubMed  Google Scholar 

  28. Kofod M, Christensen UC, la Cour M (2016) Deferral of surgery for epiretinal membranes: Is it safe? Results of a randomised controlled trial. Br J Ophthalmol 100(5):688–692

    Article  PubMed  Google Scholar 

  29. Byon IS, Pak GY, Kwon HJ, Kim KH, Park SW, Lee JE (2015) Natural history of idiopathic epiretinal membrane in eyes with good vision assessed by spectral-domain optical coherence tomography. Ophthalmologica 234(2):91–100

    Article  PubMed  Google Scholar 

  30. Byon IS, Jo SH, Kwon HJ, Kim KH, Park SW, Lee JE (2015) Changes in visual acuity after idiopathic epiretinal membrane removal: good versus poor preoperative visual acuity. Ophthalmologica 234(3):127–134

    Article  PubMed  Google Scholar 

  31. Lee SM, Pak KY, Kwon HJ, Park SW, Lee JE, Byon IS (2017) Association between tangential contraction and early vision loss in idiopathic eperetinal membrane. Retina. doi:10.1097/IAE.0000000000001559

    Google Scholar 

  32. Lommatzsch A, Heimes B, Trieschmann M, Spital G, Pauleikhoff D (2008) Long-term results after pars plana vitrectomy with 25 gauge technique. Ophthalmologe 105(5):445–451

    Article  CAS  PubMed  Google Scholar 

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Correspondence to H. Hoerauf.

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H. Hoerauf und B. Kirchhof geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben. Im Falle von nicht mündigen Patienten liegt die Einwilligung eines Erziehungsberechtigten oder des gesetzlich bestellten Betreuers vor.

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Hoerauf, H., Kirchhof, B. „Zuwarten“ als therapeutisches Prinzip bei Erkrankungen der vitreoretinalen Grenzfläche. Ophthalmologe 114, 1042–1049 (2017). https://doi.org/10.1007/s00347-017-0549-0

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