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Der Ophthalmologe

, Volume 114, Issue 5, pp 481–492 | Cite as

Fuchs-Uveitis

  • L. Daas
  • B. Seitz
  • U. Pleyer
CME

Zusammenfassung

Die Fuchs-Uveitis (FU) ist eine häufige, chronisch verlaufende intraokulare Entzündung, die mit einer schleichend einsetzenden Visusminderung einhergeht. Die klinische Manifestation der Befundtrias aus Heterochromie, Katarakt und Glaukom variiert erheblich. Dies erklärt die oft jahrelang verzögerte Diagnose. Zwar sind Ätiologie und Pathogenese der Veränderungen weiterhin nicht geklärt – allerdings besteht kein Zweifel daran, dass eine infektiöse Genese einen wesentlichen Anteil einnimmt. Die intraokulare Antikörperbildung gegen Rubella-Viren weist eine hohe Assoziation zum Krankheitsbild auf, sodass sie zur Diagnose(sicherung) herangezogen werden kann. Die Behandlung der FU ist auf symptomatische Maßnahmen begrenzt. Kortikosteroide sind meist wenig wirksam und sollten aufgrund unerwünschter Wirkungen mit Progression von Katarakt und Sekundärglaukom zurückhaltend verwendet werden. Die Prognose der Erkrankung kann als günstig eingeschätzt werden und hängt im Wesentlichen von den sekundären Veränderungen ab.

Schlüsselwörter

Anteriore Uveitis Zytomegalie-Virus Heterochromie Rubella-Virus Entzündung 

Fuchs uveitis

Abstract

Fuchs uveitis (FU) is a frequent, chronic course of intraocular inflammation, which is associated with a gradual onset of decreased visual acuity. The clinical manifestation of the triad of heterochromia, cataract and glaucoma varies considerably. This explains the often delayed diagnosis. Although the aetiology and pathogenesis of the changes are still unclear, there is no doubt that infections play a significant role. Intraocular antibodies directed against rubella viruses show a high association with the disease pattern, and their detection can even be used to support the diagnosis. The treatment of FU is limited to symptomatic measures. Corticosteroids are usually only moderately effective and should be used with caution due to adverse effects, with progression of cataract and secondary glaucoma. The prognosis of the disease can be regarded as favourable and depends essentially on the secondary changes.

Keywords

Anterior uveitis Cytomegalovirus Heterochromia Rubella virus Inflammation 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

L. Daas, B. Seitz und U. Pleyer geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH 2017

Authors and Affiliations

  1. 1.Klinik für AugenheilkundeUniversitätsklinikum des Saarlandes UKSHomburg/SaarDeutschland
  2. 2.Universitäts-AugenklinikCharité, Campus Virchow-KlinikumBerlinDeutschland

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