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Technische Grundlagen adaptiver Optiken in der Ophthalmologie

Technical principles of adaptive optics in ophthalmology

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Zusammenfassung

In den letzten 25 Jahren wurde die ophthalmologische Bildgebung revolutioniert. Dieser Review gibt einen Überblick über die Möglichkeiten adaptiver Optiken (AO) für ophthalmologische Bildgebungstechnologien und deren Entwicklung. Wir zeigen, dass die Rolle von ophthalmologischer Bildgebung sich von der Dokumentation von makroskopischen Veränderungen der Netzhaut hin zur Detektion mikroskopischer Auffälligkeiten entwickelt hat, wodurch frühzeitigere und präzisere Diagnosen ermöglicht werden. Die Implementierung von AO in bildgebende Systeme wie Funduskameras, Scanning-Laser-Ophthalmoskope und optische Kohärenztomographen spielt eine immer größere Rolle. Seit einigen Jahren entwickeln verschiedene Firmen auch kommerziell erhältliche AO-Systeme, was deren zukünftigen Einzug in die klinische Routine zeigt.

Abstract

During the last 25 years ophthalmic imaging has undergone a revolution. This review gives an overview of the possibilities of adaptive optics (AO) for ophthalmic imaging technologies and their development and illustrates that the role of ophthalmic imaging changed from the documentation of obvious abnormalities to the detection of microscopic yet significant conspicuities. This enables earlier and more precise diagnoses. The implementation of AO for imaging systems like fundus cameras, scanning laser ophthalmoscopy and optical coherence tomography has gained in importance. In recent years a couple of companies started developing commercially available AO systems, thus, indicating a future use in clinical routine.

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Danksagung

Wir danken Rigmor C. Baraas (University College of Southeast Norway, Kongsberg, Norwegen), Gereon Hüttmann (Institut für Biomedizinische Optik, Lübeck, Deutschland), Marco Lombardo (Vision Engineering Italy srl, Rom, Italien), Donald T. Miller (School of Optometry, Bloomington, IN, USA) und Austin Roorda (University of California, Berkeley, CA, USA), sowie den Firmen Boston Micromachines (Cambridge, MA, USA) und Imagine Eyes (Orsay, Frankreich) für das unkomplizierte und kurzfristige Zurverfügungstellen von Bild- und Informationsmaterial.

Förderung

Emmy Noether Programm der Deutschen Forschungsgemeinschaft (Ha 5323/5-1), Carl Zeiss Wissenschaftsfonds.

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Authors and Affiliations

  1. Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland

    J. L. Reiniger M.Sc., N. Domdei, F. G. Holz & W. M. Harmening

  2. Institut für Zoologie und Tierphysiologie, RWTH Aachen, Aachen, Deutschland

    N. Domdei

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  1. J. L. Reiniger M.Sc.
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  2. N. Domdei
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  3. F. G. Holz
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  4. W. M. Harmening
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Correspondence to J. L. Reiniger M.Sc..

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Interessenkonflikt

J.L. Reiniger, N. Domdei, F.G. Holz und W.M. Harmening geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Reiniger, J.L., Domdei, N., Holz, F.G. et al. Technische Grundlagen adaptiver Optiken in der Ophthalmologie. Ophthalmologe 114, 198–205 (2017). https://doi.org/10.1007/s00347-017-0440-z

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