Skip to main content
SpringerLink
Log in

Intraokularlinse als Medikamententräger

Intraocular lens as a drug delivery device

  • Das therapeutische Prinzip
  • Published:
Der Ophthalmologe Aims and scope Submit manuscript

Zusammenfassung

Die Intraokularlinse (IOL) als Medikamententräger ist eine Zukunftstechnologie und befindet sich derzeit in der Entwicklung. Eine pharmakologische IOL-Modifikation kann als Oberflächenmodifikation („coating“) erfolgen oder in Form einer Beladung der Optik („soaking“) oder der Haptiken mittels Slow-release-System. Therapeutische Ziele sind die Endophthalmitis, der intraokulare Reizzustand und der Nachstar.

Abstract

The development of an intraocular lens (IOL) as a drug delivery device has been the purpose of numerous preclinical studies and might become a future technology in cataract surgery. There are three techniques of pharmacological IOL modification: surface modification (coating), optic modification (soaking) or haptic modification with a slow-release-system. The therapeutic goals are endophthalmitis, postoperative inflammation and posterior capsule opacification.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Apple DJ (2007) „Nicholas Harold Lloyd Ridley. 10 July 1906–25 May 2001: Elected FRS 1986“. Biographical Memoirs of Fellows of the Royal Society 53:285–307. doi:10.1098/rsbm.2007.0022. PMID 18543467

    Article  PubMed  Google Scholar 

  2. Spalton DJ (2009) Diamond jubilee of the first intraocular lens implantation? J Cataract Refract Surg 35:2040–2041

    Article  PubMed  Google Scholar 

  3. Wenzel M, Kohnen T, Scharrer A et al (2012) Ambulante Intraokularchirurgie 2011: Ergebnisse der Umfrage von BDOC, BVA, DGII und DOG. Ophthalmo Chirurgie 24:205–214

    Google Scholar 

  4. Kohnen T, Klaproth OK, Bühren J (2009) Effect of intraocular lens ashericity on quality of vision after cataract removal: an intraindividual comparison. Ophthalmology 116:1697–1706

    Article  PubMed  Google Scholar 

  5. Lipnitzki I, Bronshtein R, Ben Eliahu S et al (2013) Hydrophilic acrylic intraocular lens as a drug delivery system: influence of the presoaking time and comparison to intracameral injection. J Ocul Pharmacol Ther 29:414–418

    Article  PubMed  CAS  Google Scholar 

  6. Endophthalmitis Study Group, European Society of Cataract & Refractive Surgeons (2007) Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors. J Cataract Refract Surg 33(6):978–988

    Article  Google Scholar 

  7. Garty S, Shirakawa R, Warsen A et al (2011) Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery. Invest Ophthalmol Vis Sci 52:6109–6116

    Article  PubMed  CAS  Google Scholar 

  8. Behrens-Baumann W (2011) Prophylaxis and therapy of postoperative endophthalmitis. Criticism of the ESCRS study and the Early Vitrectomy study. Ophthalmologe 108:1062, 1064–1066

    Article  PubMed  CAS  Google Scholar 

  9. Kugelberg M, Shafiei K, Ploeg I van der, Zetterström C (2010) Intraocular lens as a drug delivery system for dexamethasone. Acta Ophthalmol 88:241–244

    Article  PubMed  CAS  Google Scholar 

  10. Vock L, Crnej A, Findl O et al (2009) Posterior capsule opacification in silicone and hydrophobic acrylic intraocular lenses with sharp-edge optics six years after surgery. Am J Ophthalmol 147:683–690

    Article  PubMed  Google Scholar 

  11. Liu H, Wu L, Fu S et al (2009) Polylactide-glycoli acid and rapamycin coating intraocular lens prevent posterior capsular opacification in rabbit eyes. Graefes Arch Clin Exp Ophthalmol 247:801–807

    Article  PubMed  CAS  Google Scholar 

  12. Rabsilber TM, Limberger IJ, Reuland AJ et al (2007) Long-term results of sealed capsule irrigation using destilled water to prevent posterior capsule opacification: a prospective clinical randomized trial. Br J Ophthalmol 91:912–915

    Article  PubMed  Google Scholar 

  13. Leishman L, Werner L, Bodnar Z et al (2012) Prevention of capsular bag opacification with a modified hydrophilic acrylic disk-shaped intraocular lens. J Cataract Refract Surg 38:1664–1670

    Article  PubMed  Google Scholar 

  14. Eibl KH, Wertheimer C, Kernt M et al (2013) Alkylphosphocholines for intraocular lens coating. J Cataract Refract Surg 39:438–445

    Article  PubMed  Google Scholar 

  15. Dawes LJ, Illingworth CD, Wormstone IM (2012) A fully human in vitro capsular bag model to permit intraocular lens evaluation. Invest Ophthalmol Vis Sci 53:23–29

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

K. Eibl-Lindner und A. Kampik geben folgende Beziehungen an: WO 2010089389 A2 application. Mit Alkylphosphocholinen behandelte Intraokularlinsen zur pharmakologischen Nachstarprophylaxe (12.08.2010). Applicants: LMU München, Max Planck Gesellschaft, K. Eibl-Lindner, A. Kampik, H. Eibl. R. Liegl und C. Wertheimer: keine. Financial Disclosure: International Patent Application for APC Coated IOLs, LMU München, Nummer: PCT/EP2010/051490; Inventors: Eibl-Lindner, Kirsten; Kampik, Anselm; Eibl, Hansjörg; Application Number: 13/148127; Publication Date: 02/02/2012; Filing Date: 02/08/2010. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Augenklinik, LMU München, Campus Innenstadt, Mathildenstr. 8, 80336, München, Deutschland

    K.H. Eibl-Lindner FEBO, R. Liegl, C. Wertheimer & A. Kampik

Authors
  1. K.H. Eibl-Lindner FEBO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Liegl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Wertheimer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Kampik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K.H. Eibl-Lindner FEBO.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eibl-Lindner, K., Liegl, R., Wertheimer, C. et al. Intraokularlinse als Medikamententräger. Ophthalmologe 110, 990–994 (2013). https://doi.org/10.1007/s00347-013-2904-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00347-013-2904-0

Schlüsselwörter

Keywords

Search

Navigation