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Morbus Behçet – ophthalmologische und allgemeine Aspekte Teil I

Ätiologie, Pathogenese und Diagnostik

Behçet’s disease – Ophthalmological and general aspects part I

Etiology, pathogenesis and diagnostics

Der Ophthalmologe volume 109, pages 1129–1143 (2012)Cite this article

Zusammenfassung

Das Behçet-Syndrom (auch Morbus Behçet oder Adamantiades-Behçet-Erkrankung) ist eine chronische Vaskulitis, die hauptsächlich durch rekurrierende mukokutane Läsionen und visusbedrohende intraokulare Entzündungen charakterisiert ist. Es kann darüber hinaus Gelenke, alle Gefäßbahnen und das zentrale Nervensystem betreffen. Aufgrund hoher Morbidität und erheblicher Mortalität sind eine frühe Diagnostik und adäquate Therapie von großer Bedeutung. Die Behandlung und Prognose der Erkrankung konnten in den letzten Jahren deutlich durch die Einführung der „Biologika“ profitieren. Dieser Beitrag fasst den aktuellen Wissensstand zusammen und unterstreicht die bedeutende Rolle des Augenarztes bei der Diagnostik des Behçet-Syndroms.

Abstract

Behçet’s disease (also known as morbus Behcet or Admantiades-Behcet syndrome) is a chronic vasculitis mainly characterized by recurrent mucocutaneous lesions and sight threatening uveitis. It may also involve joints, vessels of all sizes and the central nervous system. Because of its severe morbidity and considerable mortality early diagnosis and treatment is important. Treatment and prognosis of this disorder have profited considerably in recent years following the introduction of biologic agents. This article summarizes the current state of knowledge and emphasizes the important role of the ophthalmologist in the diagnosis and therapy of Behçet’s disease.

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Interessenkonflikt

Der korrespondierende Autor weist für sich und seine Koautoren auf folgende Beziehungen hin: D. Hazirolan erhielt Forschungsdrittmittel von TUBITAK (The Scientific and Technological Research Council of Turkey).

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Authors and Affiliations

  1. Universitäts-Augenklinik, Uveitis Zentrum, Humboldt University, Universitätsmedizin Berlin, Charité, 13353, Berlin, Deutschland

    U. Pleyer, S. Winterhalter & N. Stübiger

  2. Department of Ophthalmology, Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey

    D. Hazirolan

Authors
  1. U. Pleyer
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  2. D. Hazirolan
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  3. S. Winterhalter
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  4. N. Stübiger
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Correspondence to U. Pleyer.

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Pleyer, U., Hazirolan, D., Winterhalter, S. et al. Morbus Behçet – ophthalmologische und allgemeine Aspekte Teil I. Ophthalmologe 109, 1129–1143 (2012). https://doi.org/10.1007/s00347-012-2698-5

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  • DOI: https://doi.org/10.1007/s00347-012-2698-5

Schlüsselwörter

  • Behçet-Syndrom
  • Diagnostik
  • Mukokutane Symptome
  • Therapie
  • Uveitis

Keywords

  • Behçet’s disease
  • Diagnosis
  • Mucocutaneous symptoms
  • Treatment
  • Uveitis