Skip to main content
SpringerLink
Log in

Ophthalmika während Schwangerschaft und Stillzeit

Ophthalmic agents during pregnancy and breastfeeding

  • Leitthema
  • Published:
Der Ophthalmologe Aims and scope Submit manuscript

Zusammenfassung

Augenerkrankungen müssen auch während der Schwangerschaft und Stillzeit behandelt werden. Der Einsatz von Medikamenten birgt ein Risiko für Mutter und Kind. Der Beitrag gibt den Kenntnisstand zur Anwendung der wichtigsten Ophthalmika in der Schwangerschaft und Stillzeit wieder. Erörtert werden die Diagnostik am Auge (Tonometrie, Mydriasis, Angiographie) und die Behandlung von Infektionen am Auge, Glaukom, Allergien, diabetische Retinopathie, Schmerzen oder Entzündungen.

Abstract

Ocular therapy is necessary even during pregnancy but the use of pharmaceutical substances bears the risk of side effects on mother and child. The article reflects current knowledge on how to treat the most important eye diseases during pregnancy and breastfeeding. The review covers the diagnostics (tonometry, mydriasis, angiography) as well as treatment of infections of the eyes, glaucoma, allergies, diabetic retinopathy, pain and inflammation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. American Academy of Pediatrics Committee on Drugs (1994) The transfer of drugs and other chemicals into human milk. Pediatrics 93:137–150

    Google Scholar 

  2. The American College of Obstetricians and Gynecologists (ACOG) and The American College of Allergy, Asthma and Immunology (ACAAI) (2000) The use of newer asthma and allergy medications during pregnancy. Ann Allergy Asthma Immunol 84:475–480

    Article  Google Scholar 

  3. Amato MP, Portaccio E, Ghezzi A et al (2010) Pregnancy and fetal outcomes after interferon-beta exposure in multiple sclerosis. Neurology 75:1794–1802

    Article  PubMed  CAS  Google Scholar 

  4. Carmichael SL, Shaw GM (1999) Maternal corticosteroid use and risk of selected congenital anomalies. Am J Med Genet 86:242–244

    Article  PubMed  CAS  Google Scholar 

  5. Chambers C, Koren G, Tutuncu ZN et al (2007) Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study. Can Fam Physician 53:409–412

    PubMed  Google Scholar 

  6. Czeizel AE, Rockenbauer M, Olsen J et al (2000) A teratological study of aminoglycoside antibiotic treatment during pregnancy. Scand J Infect Dis 32:309–313

    Article  PubMed  CAS  Google Scholar 

  7. Giamarellou H, Kolokythas E, Petrikkos G et al (1989) Pharmacokinetics of three newer quinolones in pregnant and lactating women. Am J Med 87:49S–51S

    Article  PubMed  CAS  Google Scholar 

  8. Gisbert JP (2010) Safety of immunomodulators and biologics for the treatment of inflammatory bowel disease during pregnancy and breast-feeding. Inflamm Bowel Dis 16:881–895

    Article  PubMed  Google Scholar 

  9. Heinonen O, Slone D, Shapiro S (1977) Birth defects and drugs in pregnancy. Publishing Sciences Group, Littleton

  10. Hviid A, Molgaard-Nielsen D (2011) Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ 183:796–804

    Article  PubMed  Google Scholar 

  11. Kristensen DM, Hass U, Lesne L et al (2011) Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Hum Reprod 26:235–244

    Article  PubMed  CAS  Google Scholar 

  12. Lee AG, Pless M, Falardeau J et al (2005) The use of acetazolamide in idiopathic intracranial hypertension during pregnancy. Am J Ophthalmol 139:855–859

    Article  PubMed  CAS  Google Scholar 

  13. Loebstein R, Addis A, Ho E et al (1998) Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study. Antimicrob Agents Chemother 42:1336–1339

    PubMed  CAS  Google Scholar 

  14. Madadi P, Koren G, Freeman DJ et al (2008) Timolol concentrations in breast milk of a woman treated for glaucoma: calculation of neonatal exposure. J Glaucoma 17:329–331

    Article  PubMed  Google Scholar 

  15. Martinez Lopez JA, Loza E, Carmona L (2009) Systematic review on the safety of methotrexate in rheumatoid arthritis regarding the reproductive system (fertility, pregnancy, and breastfeeding). Clin Exp Rheumatol 27:678–684

    Google Scholar 

  16. Ness T, Paulus W (2010) Eye and pregnancy. Ophthalmologe 107:863–872, quiz 873

    Article  PubMed  CAS  Google Scholar 

  17. Ostensen M (2006) Antirheumatic therapy and reproduction. The influence on fertility, pregnancy and breast feeding. Z Rheumatol 65:217–220, 222–214

    Article  PubMed  CAS  Google Scholar 

  18. Pasternak B, Hviid A (2010) Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 304:859–866

    Article  PubMed  CAS  Google Scholar 

  19. Petrou P, Georgalas I, Giavaras G et al (2010) Early loss of pregnancy after intravitreal bevacizumab injection. Acta Ophthalmol 88:e136

    PubMed  Google Scholar 

  20. Pisoni CN, D’Cruz DP (2008) The safety of mycophenolate mofetil in pregnancy. Expert Opin Drug Saf 7:219–222

    Article  PubMed  CAS  Google Scholar 

  21. Pons JC, Lebon P, Frydman R et al (1995) Pharmacokinetics of interferon-alpha in pregnant women and fetoplacental passage. Fetal Diagn Ther 10:7–10

    Article  PubMed  CAS  Google Scholar 

  22. Puig L, Barco D, Alomar A (2010) Treatment of psoriasis with anti-TNF drugs during pregnancy: case report and review of the literature. Dermatology 220:71–76

    Article  PubMed  Google Scholar 

  23. Sandberg-Wollheim M, Alteri E, Moraga MS et al (2011) Pregnancy outcomes in multiple sclerosis following subcutaneous interferon beta-1a therapy. Mult Scler 17:423–430

    Article  PubMed  CAS  Google Scholar 

  24. Schaefer C, Amoura-Elefant E, Vial T et al (1996) Pregnancy outcome after prenatal quinolone exposure. Evaluation of a case registry of the European Network of Teratology Information Services (ENTIS). Eur J Obstet Gynecol Reprod Biol 69:83–89

    Article  PubMed  CAS  Google Scholar 

  25. Sivaraman P (2004) Management of pregnancy in transplant recipients. Transplant Proc 36:1999–2000

    Article  PubMed  CAS  Google Scholar 

  26. Tarantola RM, Folk JC, Boldt HC et al (2010) Intravitreal bevacizumab during pregnancy. Retina 30:1405–1411

    Article  PubMed  Google Scholar 

  27. Verstappen SM, King Y, Watson KD et al (2011) Anti-TNF therapies and pregnancy: outcome of 130 pregnancies in the British Society for Rheumatology Biologics Register. Ann Rheum Dis 70:823–826

    Article  PubMed  CAS  Google Scholar 

  28. Wagenvoort AM, Vugt JM van, Sobotka M et al (1998) Topical timolol therapy in pregnancy: Iis it safe for the fetus? Teratology 58:258–262

    Article  PubMed  CAS  Google Scholar 

  29. Weber-Schoendorfer C, Schaefer C (2009) Multiple sclerosis, immunomodulators, and pregnancy outcome: a prospective observational study. Mult Scler 15:1037–1042

    Article  PubMed  CAS  Google Scholar 

  30. Wu Z, Huang J, Sadda S (2010) Inadvertent use of bevacizumab to treat choroidal neovascularisation during pregnancy: a case report. Ann Acad Med Singapore 39:143–145

    PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor weist für sich und seinen Koautor auf folgende Beziehungen hin: Unterstützung von klinischen Studien: Lux Brosciences, Novartis, Abbott, EsbaTech. Beratung: Lux Brosciences, Allergan, Novartis, Abbott.

Author information

Authors and Affiliations

  1. Schwerpunkt Uveitis, Universitäts-Augenklinik Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland

    T. Ness

  2. Institut für Reproduktionstoxikologie, Ravensburg, Deutschland

    W. Paulus

Authors
  1. T. Ness
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Paulus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. Ness.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ness, T., Paulus, W. Ophthalmika während Schwangerschaft und Stillzeit. Ophthalmologe 109, 221–228 (2012). https://doi.org/10.1007/s00347-011-2459-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00347-011-2459-x

Schlüsselwörter

Keywords

Search

Navigation