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Histologische Diagnostik eines bestrahlten Aderhautmelanoms

Histological findings in an irradiated choroidal melanoma

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Zusammenfassung

Hintergrund

Histologische Veränderungen nach Protonenbestrahlung eines Aderhautmelanoms sind für komplizierte Verläufe nach Enukleation dokumentiert. Hier wird die Histologie eines Tumors nach transretinaler Probeentnahme dargestellt.

Patienten und Methoden

Ein Jahr nach Bestrahlung wurde eine Biopsie des Tumors histologisch untersucht.

Ergebnisse

Das Biopsat zeigte vitale, Melan-A- und HMB-45-positive pigmentierte spindelige Tumorzellen in fibrösem Stroma und wenige proliferierende Zellen. Eine Caspase-3-Färbung war unauffällig.

Schlussfolgerungen

Das Melanom wies morphologisch vitale und einzelne proliferierende Zellen auf. Dennoch kam es im Verlauf ohne weitere Therapie zu einer Regression.

Abstract

Background

Histological findings of choroidal melanomas after proton beam irradiation have been reported for complicated cases after enucleation. We present specimens of a tumor after transretinal probe excision.

Patient and methods

One year after irradiation, the biopsy was examined histologically.

Results

The specimens showed pigmented, spindle-shaped cells staining positively for Melan-A and HMB-45. Ki-67 showed low proliferation. Caspase-3 staining was normal.

Conclusions

The melanoma still contained vital and even single proliferating cells, but regressed afterwards without additional therapy.

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Literatur

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Authors and Affiliations

  1. Klinik für Ophthalmologie, UK-SH Campus Kiel, Arnold-Heller-Str. 3, Haus 25, 24105, Kiel, Deutschland

    S. Koinzer, H. Hasselbach & J. Roider

  2. Institut für Pathologie, UK-SH Campus Kiel, Kiel, Deutschland

    J.H. Bräsen & I. Leuschner

Authors
  1. S. Koinzer
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  2. H. Hasselbach
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  3. J.H. Bräsen
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  4. I. Leuschner
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  5. J. Roider
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Corresponding author

Correspondence to S. Koinzer.

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Koinzer, S., Hasselbach, H., Bräsen, J. et al. Histologische Diagnostik eines bestrahlten Aderhautmelanoms. Ophthalmologe 108, 570–574 (2011). https://doi.org/10.1007/s00347-011-2339-4

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  • DOI: https://doi.org/10.1007/s00347-011-2339-4

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