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Akute Visusminderung während der Therapie einer chronischen Hepatitis C

Acute loss of vision during therapy of chronic hepatitis C

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Zusammenfassung

Ein Patient mit chronischer Hepatitis C unter der kombinierten Therapie mit pegyliertem Interferon-α-2a (Peg-IFN-α-2a) und Ribavirin entwickelte eine plötzliche ausgeprägte Visusminderung. Es zeigte sich ein Zentralvenenverschluss mit Makulaödem, der mit intravitrealem Bevacizumab behandelt wurde. Retinale Verschlüsse sind als Komplikation der Therapie mit Peg-IFN-α-2a und Ribavirin bekannt. Eine interdisziplinäre Betreuung sowie eine frühe anti-VEGF-Applikation können bei der Therapie dieser Komplikation einer chronischen Hepatitis C von Nutzen sein.

Abstract

A patient undergoing combined therapy of chronic hepatitis C with pegylated interferon-α-2a (PEG-IFN-α-2a) and ribavirin suddenly developed severe loss of visual acuity. A central vein occlusion with macular edema was found and intravitreal injections of bevacizumab were initiated. Retinal occlusion is a known complication of therapy with pegylated interferon-α-2a and ribavirin. An interdisciplinary assessment of patients treated for a chronic hepatitis C as well as an early anti-VEGF administration can be helpful in the therapy of this complication of chronic hepatitis C.

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Literatur

  1. Gregori NZ, Gaitan J, Rosenfeld PJ et al (2008) Long-term safety and efficacy of intravitreal bevacizumab (Avastin) for the management of central retinal vein occlusion. Retina 28:1325–1337

    Article  PubMed  Google Scholar 

  2. Kim ET, Kim LH, Lee JI et al (2009) Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin. Jpn J Ophthalmol 53:598–602

    Article  PubMed  CAS  Google Scholar 

  3. Marcellin P (2009) Hepatitis B and hepatitis C in. Liver Int 29(Suppl 1):1–8

    Article  PubMed  Google Scholar 

  4. Nadir A, Amin A, Chalisa N et al (2000) Retinal vein thrombosis associated with chronic hepatitis C: a case series and review of the literature. J Viral Hepat 7:466–470

    Article  PubMed  CAS  Google Scholar 

  5. Priglinger SG, Wolf AH, Kreutzer TC et al (2007) Intravitreal bevacizumab injections for treatment of central retinal vein occlusion: six-month results of a prospective trial. Retina 27:1004–1012

    Article  PubMed  Google Scholar 

  6. Rubio JE Jr, Charles S (2003) Interferon-associated combined branch retinal artery and central retinal vein obstruction. Retina 23:546–548

    Article  PubMed  Google Scholar 

  7. Sene D, Touitou V, Bodaghi B et al (2007) Intraocular complications of IFN-alpha and ribavirin therapy in patients with chronic viral hepatitis C. World J Gastroenterol 13:3137–3140

    PubMed  CAS  Google Scholar 

  8. Shepard CW, Finelli L, Alter MJ (2005) Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 5:558–567

    Article  PubMed  Google Scholar 

  9. Zandieh I, Adenwalla M, Cheong-Lee C et al (2006) Retinal vein thrombosis associated with pegylated-interferon and ribavirin combination therapy for chronic hepatitis C. World J Gastroenterol 12:4908–4910

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Augenklinik und Poliklinik, Universität Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Deutschland

    J.P. Salgado

  2. Augenklinik und Poliklinik, TU München, München, Deutschland

    R. Khoramnia, M.M. Maier, C.P. Lohmann & C. Winkler von Mohrenfels

Authors
  1. J.P. Salgado
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  2. R. Khoramnia
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  3. M.M. Maier
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  4. C.P. Lohmann
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  5. C. Winkler von Mohrenfels
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Correspondence to J.P. Salgado.

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Salgado, J., Khoramnia, R., Maier, M. et al. Akute Visusminderung während der Therapie einer chronischen Hepatitis C. Ophthalmologe 108, 561–564 (2011). https://doi.org/10.1007/s00347-010-2327-0

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  • DOI: https://doi.org/10.1007/s00347-010-2327-0

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