Zusammenfassung
Die konfokale Scanning-Laser-Ophthalmoskopie mittels der Heidelberg Retina Tomographie (HRT) bietet ein Diagnoseverfahren, welches schnelle, nichtinvasive topographische Informationen über den Sehnervenkopf, den neuroretinalen Randsaum und über die retinale Nervenfaserschichtdicke liefert. Der HRT ist aktuell eines der führenden Systeme für die Diagnose und Verlaufskontrolle eines Glaukoms. Die Implementation von diversen Auswertestrategien wie der Moorfields Regressionsanalyse (MRA) und des Glaucoma Probability Scores (GPS) sowie Diskriminanzanalysen helfen dem Kliniker, ein Glaukomauge von einem gesunden Auge zu unterscheiden. Für die Verlaufskontrolle können neben der Änderung der stereometrischen Parameter die Topographic Change Analysis (TCA) und die Trendanalyse verwendet werden. Außerdem bietet der Flickervergleich wertvolle Möglichkeiten, um topographische Änderungen im Vergleich zur Basisuntersuchung zu evaluieren. Die wichtige klinische Untersuchung wird bei richtiger Anwendung des Verfahrens und entsprechender Erfahrung mit der Interpretation sinnvoll ergänzt.
Abstract
The Heidelberg Retina Tomograph (HRT) is a glaucoma diagnosis system that provides fast, noninvasive topographic information about the optic nerve head, the neuroretinal rim, and the thickness of the nerve fiber layer. With these capabilities, it is one of the leading laser systems for detecting glaucoma. Statistical methods such as the Moorfields regression analysis and the glaucoma probability score, as well as discriminant functions implemented in the instrument, support the clinician in discriminating between glaucoma and healthy eyes. The primary method for assessing glaucomatous change using the HRT is topographic change analysis, a technique that compares the variability within a baseline examination to that between baseline and follow-up examinations. The stereometric trend analysis reports changes in normalized topographic parameters over time. Furthermore, the flicker comparison enables the detection of small topographic changes over time. The use of HRT does not replace clinical examination but facilitates the assessment and management of glaucoma according to the observer’s experience.
Literatur
Girkin C (2006) Grundlagen der konfokalen Laser-Scan-Technik für den Arzt. In: Fingeret M, Flanagan J, Liebmann J (Hrsg) HRT Fibel. Heidelberg Engineering, Heidelberg, S 1–9
HRT Benutzerhandbuch
Strouthidis NG, White ET, Garway-Heath DF (2003) An Evaluation of the Test-retestvariability of the HRT-II and the influence of Degree of Lenticular Opacity. ARVO, pp 3351–3351
Verdonck N, Zeyen T, Van Malderen L, Spileers W (2002) Short-term intra-individual variability in Heidelberg retina tomograph II. Bull Soc Belge Ophtalmol 11:51–57
Wollstein G, Garway-Heath DF, Hitchings RA (1998) Identification of early glaucoma cases with the scanning laser ophthalmoscope. Ophthalmology 105:1557–1563
Jonas JB, Gusek GC, Naumann GO (1988) Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. Invest Ophthalmol Vis Sci 29:1151–1158
Britton RJ, Drance SM, Schulzer MD et al (1987) The area of the neuroretinal rim of the optic nerve in normal eyes. Am J Ophthalmol 103:497–504
Garway-Heath DF, Wollstein G, Hitchings RA (1997) Aging changes of the optic nerve head in relation to open angle glaucoma. Br J Ophthalmol 81:840–845
Pickard R (1948) The alteration in size of the normal optic disc cup. Br J Ophthalmol 32:355–361
Jonas JB, Budde WM (2000) Diagnosis and pathogenesis of glaucomatous optic neuropathy: morphological aspects. Prog Retin Eye Res 19:1–4
Garway-Heath F (2006) Moorfields-Regressionsanalyse. In: Fingeret M, Flanagan JG, Liebmann J (Hrsg) HRT Fibel. Heidelberg Engineering, Heidelberg, S 31–41
Krieglstein G (2000) Frühdiagnose und Compliance verbessern Langzeitverlauf. In: Erb C, Krieglstein G (Hrsg) Glaukom: Fragen zur Praxis. Agamede, Köln, S 27–43
Fingeret M (2006) Bildaufnahme und Datenanalyse mit dem Heidelberg Retina Tomographen. In: Fingeret M, Flanagan JG, Liebmann J (Hrsg) HRT Fibel. Heidelberg Engineering, Heidelberg, S 11–30
Iester M, Mikelberg FS, Courtright P et al (2001) Interobserver variability of optic disk variables measured by confocal scanning laser tomography. Am J Ophthalmol 132:57–62
Miglior S, Albé E, Guareschi M et al (2002) Intraobserver and interobserver reproducibility in the evaluation of optic disc stereometric parameters by Heidelberg Retina Tomograph. Ophthalmology 109:1072–1077
Garway-Heath DF, Poinoosawmy D, Wollstein G et al (1999) Inter- and intraobserver variation in the analysis of optic disc images: comparison of the Heidelberg Retina Tomograph and computer assisted planimetry. Br J Ophthalmol 83:664–669
Swindale NV, Stjepanovic G, Chin A, Mikelberg FS (2000) Automated analysis of normal and glaucomatous optic nerve head topography images. Invest Ophthalmol Vis Sci 41:1730–1742
Coops A, Henson DB, Kwartz AJ, Artes PH (2006) Automated analysis of heidelberg retina tomograph optic disc images by glaucoma probability score. Invest Ophthalmol Vis Sci 47:5348–5355
Harizman N, Zelefsky JR, Ilitchev E et al (2006) Detection of glaucoma using operator-dependent versus operator-independent classification in the Heidelberg retinal tomograph-III. Br J Ophthalmol 90:1390–1392
Moreno-Montañés J, Antón A, García N et al (2008) Glaucoma Probability Score vs Moorfields Classification in Normal, Ocular Hypertensive, and Glaucomatous Eyes. Am J Ophthalmol 145:360–368
Zangwill LM, Jain S, Racette L et al (2007) The effect of disc size and severity of disease on the diagnostic accuracy of the Heidelberg retina tomograph glaucoma probability score. Invest Ophthalmol Vis Sci 48:2653–2660
Strouthidis NG, Garway-Heath DF (2009) Detecting Glaucoma Progression by Imaging. In: Grehn F, Stamper R (eds) Essentials in Ophthalmology: Glaucoma Progression III. Springer, Heidelberg
Breusegem C, Fieuws S, Stalmans I, Zeyen T (2008) Variability of the standard reference height and its influence on the stereometric parameters of the heidelberg retina tomograph 3. Invest Ophthalmol Vis Sci 49(11):4881–4885
Chauhan B (2006) Nachweis glaukomatöser Veränderungen des Sehnervenkopfes. In: Fingeret M, Flanagan JG, Liebmann J (Hrsg) HRT Fibel. Heidelberg engineering, Heidelberg, S 53–67
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Hoffmann, E., Lamparter, J., Schmidt, T. et al. Glaukomdiagnostik und Verlaufskontrolle mit dem Heidelberg Retina Tomograph. Ophthalmologe 106, 687–695 (2009). https://doi.org/10.1007/s00347-009-1998-x
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DOI: https://doi.org/10.1007/s00347-009-1998-x
Schlüsselwörter
- Konfokale Scanning-Laser-Ophthalmoskopie
- Heidelberg Retina Tomograph
- Glaucoma Probability Score
- Moorfields Regressionsanalyse
- Topographic Change Analysis