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Chemische und spektroskopische Aspekte der Verwendung von Farbstoffen in der vitreoretinalen Chirurgie

Chemical and spectroscopic aspects of the application of dyes in vitreoretinal surgery

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Zusammenfassung

In diesem Beitrag werden die Vorteile der Verwendung optischer Kontrastmittel in der Chirurgie, wie z. B. der vitreoretinalen Mikrochirurgie, vorgestellt. Die Anforderungen an diese Hilfsmittel, ihre Verwendungsmöglichkeiten und Grenzen werden anhand koloristischer Eigenschaften diskutiert. Des Weiteren wird ein Überblick über fluoreszierende Kontrastmittel gegeben.

Abstract

The advantages of the use of optical contrast agents in surgery, such as vitreoretinal microsurgery, are presented. Requirements concerning these materials and the potentials and limitations of their application are discussed on the basis of their coloristic properties. Applications of fluorescent dyes are examined.

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Literatur

  1. Akilov OE, Kosaka S, O’Riordan K, Hasan T (2007) Photodynamic therapy for cutaneous leishmaniasis: the effectiveness of topical phenothiaziniums in parasite eradication and Th1 immune response stimulation. Photochem Photobiol Sc 6:1067–1075

    Article  CAS  Google Scholar 

  2. Brown SB, O’Grady CC, Griffiths J et al (2005) Preparation of phenothiazinium salts as antimicrobials for use in photodynamic therapy (PDT). PCT Int Appl WO 2005054217 (16.6.2005). Chem Abstr 143:59990

    Google Scholar 

  3. Chamberlin GJ, Chamberlin DG (1980) Colour; its measurement, computation and application. Heyder, London

  4. Giovannini A, Scassellati-Sforzolini B, Mariotti C, D’Altobrando E (1996-1997) Indocyanine green angiographic findings in idiopathic choroidal neovascularization. Int Ophthalmol 20:171–179

    PubMed  Google Scholar 

  5. Haritoglou C, Gandorfer A, Gass CA et al (2002) Indocyanine green-assisted peeling of the internal limiting membrane in macular hole surgery affects visual outcome: a clinicopathologic correlation. Am J Ophthalmol 134:836–841

    Article  PubMed  Google Scholar 

  6. Haritoglou C, Kampik A, Langhals H (2008) Indocyanine green should not be used to facilitate removal of the internal limiting membrane in macular hole surgery. Sur Ophthalmol (in press)

  7. Haritoglou C, Freyer W, Priglinger SG, Kampik A (2006) Light absorbing properties of Indocyanine Green (ICG) in solution and after adsorption to the retinal surface - an ex-vivo approach. Graefes Arch Clin Exp Ophthalmol 244:1196–1202

    Article  PubMed  CAS  Google Scholar 

  8. Heseltine DW, Brooker LGS (1959) Tricarbocyanine infrared-absorbing dyes. US 2895955 (21.7.1959). Chem Abstr 54:825

    Google Scholar 

  9. Igarashi H, Kamisaka K, Maezawa H, Uesugi T (1990) Degradation and metabolism of indocyanine green: high-pressure liquid chromatographic analysis. Bull Tokyo Med Dent Univ 37:59–69

    PubMed  CAS  Google Scholar 

  10. Landsman MLJ, Kwant G, Mook GA, Zijlstra WG (1976) Light- absorbing properties, stability and spectral stabilization of Indocyanine Green. J Appl Physiol 40:575–583

    PubMed  CAS  Google Scholar 

  11. Rodrigues EB, Maia M, Meyer CH, Penha FM (2007) Vital dyes for chromovitrectomy. Curr Op Ophthalmol 18:179–187

    Article  Google Scholar 

  12. Ruefer F, Frimpong-Boateng A, Bunse A, Roider J (2007) Comparison of ILM peeling with and without the use of Indocyanine green. Ophthalmologe 104:54–59

    Article  CAS  Google Scholar 

  13. Saxena V, Sadoqi M, Shao Jun (2003) Degradation kinetics of Indocyanine green in aqueous solution. J Pharm Sc 92:2090–2097

    Article  CAS  Google Scholar 

  14. Scheibe G (1936) Angew Chem 49:563

  15. Smith T, Guild J (1931-32) The C.I.E. colorimetric standards and their use. Transac Opt Soc 33:73–134. DOI:10.1088/1475-4878/33/3/301

  16. Wheeler HO, Cranston WmI, Meltzer JI (1958) Hepatic uptake and biliary excretion of indocyanine green in the dog. Proc Soc Exper Biol Medicine 99:11–14. Chem Abstr 53:24688

    Google Scholar 

  17. Zollinger H (2003) Color chemistry, synthesis, properties and applications of organic dyes and pigments, 3rd edn. Wiley, Zürich

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Correspondence to H. Langhals.

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Diese Arbeit wurde vom Fonds der Chemischen Industrie gefördert.

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Langhals, H., Haritoglou, C. Chemische und spektroskopische Aspekte der Verwendung von Farbstoffen in der vitreoretinalen Chirurgie. Ophthalmologe 106, 16–20 (2009). https://doi.org/10.1007/s00347-008-1855-3

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  • DOI: https://doi.org/10.1007/s00347-008-1855-3

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