Zusammenfassung
Diese Arbeit gibt einen Überblick über die wichtigsten Vitalfarbstoffe und Hilfsmittel, die gegenwärtig für den Einsatz im Rahmen vitreoretinaler Eingriffe verwendet werden bzw. zugelassen sind. Die Möglichkeiten der intraoperativen Applikation und Färbeeigenschaften werden beschrieben. Ergänzend wird die Biokompatibilität dieser Substanzen diskutiert.
Abstract
This article reviews the most relevant vital dyes and adjuncts currently available for use in vitreoretinal surgical procedures. The current concepts of intraocular application as well as the staining properties are described, and the issue of biocompatibility is discussed.
Literatur
Bressman PL, Seto F (1976) Neural abnormalities induced by selected chemical agents. Proc Okla Acad Sci 56:10–14
Cheng SN, Yang TC, Ho JD et al (2005) Ocular toxicity of intravitreal indocyanine green. J Ocul Pharmacol Ther 21:85–93
Enaida H, Hisatomi T, Goto Y et al (2006) Preclinical investigation of internal limiting membrane staining and peeling using intravitreal brilliant blue G. Retina 26:623–630
Enaida H, Hisatomi T, Hata Y et al (2006) Brilliant blue G selectively stains the internal limiting membrane/brilliant blue G-assisted membrane peeling. Retina 26:631–636
Feron EJ, Veckeneer M, Parys-Van Ginderdeuren R et al (2002) Trypan blue staining of epiretinal membranes in proliferative vitreoretinopathy. Arch Ophthalmol 120:141–144
Furino C, Micelli Ferrari T, Boscia F et al (2003) Triamcinolone-assisted pars plana vitrectomy for proliferative vitreoretinopathy. Retina 23:771–776
Georgiadis N, Kardasopoulos A, Bufidis T (1999) The evaluation of corneal graft tissue by the use of trypan blue. Ophthalmologica 213:8–11
Haritoglou C, Eibl K, Schaumberger M et al (2004) Functional outcome after trypan blue-assisted vitrectomy for macular pucker: a prospective, randomized, comparative trial. Am J Ophthalmol 138:1–5
Haritoglou C, Gandorfer A, Gass CA et al (2002) Indocyanine green-assisted peeling of the internal limiting membrane in macular hole surgery affects visual outcome: A clinicopathologic correlation. Am J Ophthalmol 134:836–841
Haritoglou C, Gandorfer A, Schaumberger M et al (2004) Trypan blue in macular pucker surgery: an evaluation of histology and functional outcome. Retina 24:582–590
Horiguchi M, Miyake K, Ohta I, Ito Y (1998) Staining of the lens capsule for circular continuous capsulorrhexis in eyes with white cataract. Arch Ophthalmol 116:535–537
Horio N, Horiguchi M (2004) Effect on visual outcome after macular hole surgery when staining the internal limiting membrane with indocyanine green dye. Arch Ophthalmol 122:992–996
Kadonosono K, Itoh N, Uchio E et al (2000) Staining of the internal limiting membrane in macular hole surgery. Arch Ophthalmol 118:1116–1118
Kanda S, Uemura A, Yamashita T et al (2004) Visual field defects after intravitreous administration of indocyanine green in macular hole surgery. Arch Ophthalmol 122:1447–1451
Lesnik Oberstein SY, Mura M, Tan SH, de Smet MD (2007) Heavy trypan blue staining of epiretinal membranes: an alternative to infracyanine green. Br J Ophthalmol 91(7):955–957
Lüke M, Januschowski K, Beutel J et al (2008) Electrophysiological effects of brilliant blue G in the model of the isolated perfused vertebrate retina. Graefes Arch Clin Exp Ophthalmol 246(6):817–822
McEnerny JK, Peyman GA (1978) Indocyanine green: a new vital stain for use before penetrating keratoplasty. Arch Ophthalmol 96:1445–1447
Melles GR, de Waard PW, Pameijer JH, Beekhuis WH (1999) Staining the lens capsule with trypan blue for visualizing capsulorrhexis in surgery of mature cataracts. Klin Monatsbl Augenheilkd 215:342–344
Perrier M, Sebag M (2003) Epiretinal membrane surgery assisted by trypan blue. Am J Ophthalmol 135:909–911
Posselt D, Rahman R, Smith M, Simcock PR (2005) Visual outcomes following ICG assisted ILM peel for macular hole. Eye 19:279–283
Remy M, Thaler S, Schumann RG et al (2008) An in-vivo evaluation of brilliant blue G in animals and humans. Br J Ophthalmol 92:1142–1147
Sakamoto T, Miyazaki M, Hisatomi T et al (2002) Triamcinolone-assisted pars plana vitrectomy improves the surgical procedures and decreases the postoperative blood-ocular barrier breakdown. Graefes Arch Clin Exp Ophthalmol 240:423–429
Schmidt JC, Chofflet J, Hörle S et al (2008) Three simple approaches to visualize the transparent vitreous cortex during vitreoretinal surgery. Dev Ophthalmol 42:35–42
Sippy BD, Engelbrecht NE, Hubbard GB et al (2001) Indocyanine green effect on cultered human retinal pigment epithelial cells: Implication for macular hole surgery. Am J Ophthalmol 132:433–435
Tewari A, Almony A, Shah GK (2008) Macular hole closure with triamcinolone-assisted internal limiting membrane peeling. Retina 10. Epub ahead of print, 10.07.2008
Tognetto D, Zenoni S, Sanguinetti G et al (2005) Staining of the internal limiting membrane with intravitreal triamcinolone acetonide. Retina 25:462–467
Uemoto R, Yamamoto S, Takeuchi S (2005) Changes in retinal pigment epithelium after indocyanine green-assisted internal limiting lamina peeling during macular hole surgery. Am J Ophthalmol 140:752–755
Ueno A, Hisatomi T, Enaida H et al (2007) Biocompatibility of brilliant blue G in a rat model of subretinal injection. Retina 27:499–504
Yao Y, Wang ZJ, Wei SH et al (2007) Oral sodium fluorescein to improve visualization of clear vitreous during vitrectomy for proliferative diabetic retinopathy. Clin Experiment Ophthalmol 35(9):824–827
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Haritoglou, C., Thaler, S., Kampik, A. et al. Farbstoffe in der vitreoretinalen Chirurgie. Ophthalmologe 106, 7–10 (2009). https://doi.org/10.1007/s00347-008-1853-5
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00347-008-1853-5