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Faltenbehandlung durch Botulinumtoxin

Treatment of wrinkles with botulinum toxin

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Zusammenfassung

Botulinumtoxin-A wird in der ästhetischen Medizin zur Faltenbehandlung eingesetzt. Die Gabe von Botulinumtoxin-A verhindert die Exozytose von Acetylcholin abhängig vom Zielgewebe für 3–12 Monate. Niedrig dosiertes Botulinumtoxin-A eignet sich zur Therapie von mimischen Gesichtsfalten besonders in der oberen Gesichtshälfte, da die dort behandelten Muskeln (v. a. der M. procerus, M. corrugator supercilii, M. frontalis und M. orbicularis oculi) den Gesichtsknochen direkt aufliegen. Im Gegensatz dazu ist dies in der unteren Gesichtshälfte im Mundbereich nicht der Fall, was leichter zu Nebenwirkungen wie z. B. Hängen des Mundwinkels führt. Kontraindikationen sind Erkrankungen der neuromuskulären Signaltransduktion, Allergien gegen Bestandteile der Lösung, Einnahme von Aminoglykosiden und Acetylsalicylsäure vor der Behandlung, Infektionen im Bereich der Injektionsstellen sowie Schwangerschaft und Stillzeit. Alternative und komplementäre Verfahren zur Faltenbehandlung sind Erbium-YAG- oder CO2-Laseranwendungen, Augmentationsverfahren sowie plastische Operationen.

Abstract

The use of botulinum toxin A for the treatment of wrinkles is increasing. Botulinum toxin A inhibits exocytosis of acetylcholine from 3 to 12 months, depending on the target tissue. Low-dose botulinum toxin A is used to smooth hyperkinetic facial lines. This is especially successful in the upper facial parts, since the target muscles (procerus, corrugator supracilii, frontalis, orbicularis oculi) all directly overlie the osseous structures of the face. This is not the case for the lower facial parts, and more side effects are encountered when treating, for example, wrinkles around the mouth. Contraindications to the use of botulinum toxin A are diseases affecting neuromuscular signal transduction, allergic reactions to components of the solution, therapy with aminoglycosides or acetylsalicylic acid prior to treatment, infections in the planned treatment area, and pregnancy and lactation. Alternative and complementary treatments include erbium-YAG or CO2 laser, as well as augmentation and surgical plastic procedures.

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Lanzl, I., Merté, RL. Faltenbehandlung durch Botulinumtoxin. Ophthalmologe 104, 777–782 (2007). https://doi.org/10.1007/s00347-007-1614-x

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