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Bestimmung der peripapillären Nervenfaserschichtdicke mit der optischen Kohärenztomographie (OCT) in verschiedenen Abständen zum Papillenrand

Measurement of peripapillary nerve fiber layer thickness at different distances from the optic nerve head with OCT

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Zusammenfassung

Hintergrund

Ziel der Studie war es, den Durchmesser von zirkulären OCT-Scans um die Papille zu bestimmen, bei dem am besten zwischen Glaukom und Gesunden unterschieden werden kann.

Methoden

98 Augen von 67 Probanden (Augengesunde und PCOWG-Patienten) wurden mit dem Stratus-OCT (Fa. Zeiss, Modell 3000, Software Version 2.0) untersucht. Die Scans wurden im „Proportional circle mode“ und mit dem „RNFL-Thickness-Analysis“-Protokoll analysiert. Für die Statistik wurden der Friedman-Test und der Mann-Whitney-U-Test mit Bonferroni-Korrektur verwendet.

Ergebnisse

Von 23 gesunden und 19 Glaukomaugen konnten vollständige Datensätze mit der OCT-Software analysiert werden. Die Nervenfaserschichtdicke war jeweils innerhalb beider Gruppen zwischen den Scans mit unterschiedlichem Durchmesser statistisch signifikant verschieden (p=0,000). Zwischen den beiden Gruppen unterschied sie sich statistisch signifikant beim einfachen (p=0,003), beim 1,4fachen (p=0,01) und beim 1,8fachen Papillendurchmesser (p=0,002).

Zusammenfassung

Zirkuläre Scans mit dem einfachen und dem 1,8fachen Papillendurchmesser scheinen am besten zwischen Augengesunden und Glaukompatienten unterscheiden zu können.

Abstract

Purpose

The aim of this study was to assess which distance to the optic nerve head is most favorable for circular measurements of retinal nerve fiber layer thickness (RNFLT) with OCT to detect differences between glaucoma and normal subjects.

Methods

A total of 98 eyes of 67 subjects (normal subjects and POAG patients) were examined by Stratus OCT (Zeiss, Model 3000, Software Version 2.0). Images were scanned in the “proportional circle” mode and analyzed with the “RNFL thickness analysis” protocol. For statistical analysis the Friedman test and the Mann-Whitney U test with Bonferroni correction were used.

Results

For 23 normal and 19 eyes of POAG patients a complete set of scans could be analyzed by the OCT software. RNFLT was statistically significantly different in scan diameters in both groups (P=0.000). Differences between the groups were statistically significant for the 1.0-fold (P=0.003), for the 1.4-fold (P=0.01), and for the 1.8-fold (P=0.002) disc diameter.

Conclusion

Circular scans with a 1-fold and with a 1.8-fold disc diameter seem to be able to differentiate best between glaucoma and normal subjects.

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Authors and Affiliations

  1. Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Carl Gustav Carus, Dresden

    A. G. Böhm, E. Schmidt, M. Müller-Holz & L. E. Pillunat

  2. Universitäts-Augenklinik, Dresden, Fetscherstraße 74, 01307 , Dresden

    A. G. Böhm

Authors
  1. A. G. Böhm
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  2. E. Schmidt
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  3. M. Müller-Holz
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  4. L. E. Pillunat
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Correspondence to A. G. Böhm.

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Teile des Beitrags wurden auf der 101. Tagung der Deutschen Ophthalmologischen Gesellschaft in Berlin vorgetragen.

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Böhm, A.G., Schmidt, E., Müller-Holz, M. et al. Bestimmung der peripapillären Nervenfaserschichtdicke mit der optischen Kohärenztomographie (OCT) in verschiedenen Abständen zum Papillenrand. Ophthalmologe 103, 387–392 (2006). https://doi.org/10.1007/s00347-005-1309-0

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  • DOI: https://doi.org/10.1007/s00347-005-1309-0

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