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Das Komplementsystem und dessen mögliche Beteiligung an der Pathogenese der altersabhängigen Makuladegeneration (AMD)

The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)

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Zusammenfassung

Spätestens seit der Entdeckung der Rolle des Komplementfaktor-H- (CFH-) Polymorphismus bei der altersabhängigen Makuladegeneration (AMD) scheint eine Beteiligung des Komplementsystems an der Pathogenese dieser Erkrankung gesichert. Das Komplementsystem gehört zum unspezifischen Abwehrsystem und ist eng mit zellulären Immunantworten und dem spezifischen Abwehrsystem verknüpft. Anhand der derzeitigen Datenlage soll hier eine Übersicht über das Komplementsystem und mögliche immunpathogenetische Vorgänge bei der AMD gegeben werden.

Abstract

The discovery of the complement factor H (CFH) polymorphism in age-related macular degeneration (AMD) strongly suggests a causative role of the complement system in the pathogenesis of this disease. The complement system is part of the innate immune system and is closely associated with the cellular response and the adaptive immune system. This article provides an overview of the complement system and, taking the new data into account, of possible immunopathogenetic processes in AMD.

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Authors and Affiliations

  1. Augenklinik, Universität, Bonn

    P. Charbel Issa,  H. P. N. Scholl & F. G. Holz

  2. Institut für molekulare Medizin und experimentelle Immunologie, Universität, Bonn

    P. Knolle & C. Kurts

  3. Augenklinik, Universität, Ernst-Abbe-Straße 2, 53127 , Bonn

    H. P. N. Scholl

Authors
  1. P. Charbel Issa
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  2. H. P. N. Scholl
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  3. F. G. Holz
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  4. P. Knolle
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  5. C. Kurts
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Corresponding author

Correspondence to H. P. N. Scholl.

Additional information

Unterstützt durch: Europäische Gemeinschaft (EU) FP5, QoL, KA6, Concerted Action QLRT-2001–02494 „PHOTAGE“; EU FP6, Integrated Project „EVI-GENORET“ (LSHG-CT-2005–5120; Vetragsnummer 512036); Deutsche Forschungsgemeinschaft (DFG) Heisenberg-Stipendium SCHO 734/2–1; DFG Ho 1926/1–3; DFG Schwerpunktprogramm Altersabhängige Makuladegeneration“ SPP 1088.

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Charbel Issa, P., Scholl, H.P.N., Holz, F.G. et al. Das Komplementsystem und dessen mögliche Beteiligung an der Pathogenese der altersabhängigen Makuladegeneration (AMD). Ophthalmologe 102, 1036–1042 (2005). https://doi.org/10.1007/s00347-005-1269-4

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  • DOI: https://doi.org/10.1007/s00347-005-1269-4

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