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Uveitis bei rheumatologischen Erkrankungen im Kindesalter

Uveitis in conjunction with rheumatological diseases in childhood

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Zusammenfassung

Kinder mit einer chronischen Arthritis haben je nach Erkrankungstyp ein unterschiedliches Risiko für die Entwicklung einer anterioren Uveitis. Die pathogenetischen Hintergründe sind unklar, allerdings ist eine Assoziation mit antinukleären Antikörpern beschrieben. Junge Mädchen mit oligoartikulärem Beginn der Arthritis sind am häufigsten betroffen. Regelmäßige augenärztliche Untersuchungen sollen eine frühzeitige Diagnose und effektive Therapie ermöglichen. Komplikationen wie Synechien, Katarakt oder Visusminderung treten insbesondere bei später Erstdiagnose und nicht ausreichender antiinflammatorischer Behandlung auf. Bessere Therapieregime haben in den letzten Jahren die Prognose der intraokularen Entzündung verbessert.

Abstract

Children with juvenile chronic arthritis are at risk to develop intraocular inflammation depending on the type of arthritis. The pathogenic mechanisms are unclear; however, an association with antinuclear antibodies is well known. In particular young girls with oligoarticular onset of arthritis are affected most often. Regular ophthalmologic examinations should allow early diagnosis and effective therapy. Complications such as synechiae, cataract, or macula edema are seen especially in uveitis patients with late diagnosis and insufficient anti-inflammatory therapy. Better therapeutic regimens have led to a better overall prognosis of intraocular inflammation in recent years.

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  1. Klinik für Pädiatrie mit Schwerpunkt Pneumologie und Immunologie, Campus Virchow-Klinikum der Charité-Universitätsmedizin, Berlin

    C. Sengler & R. Keitzer

  2. Universitätsaugenklinik, Campus Virchow-Klinikum der Charité-Universitätsmedizin, Berlin

    U. Pleyer

  3. Universitätsaugenklinik, Campus Virchow-Klinikum der Charité-Universitätsmedizin, Augustenburger Platz 1, 13353 , Berlin

    U. Pleyer

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Sengler, C., Keitzer, R. & Pleyer, U. Uveitis bei rheumatologischen Erkrankungen im Kindesalter. Ophthalmologe 102, 463–476 (2005). https://doi.org/10.1007/s00347-005-1182-x

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