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Photodynamische Therapie bei chorioidalen Hämangiomen

Langzeitergebnisse

Photodynamic therapy for choroidal hemangioma

Long-term results

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An Erratum to this article was published on 01 August 2004

Zusammenfassung

Hintergrund

Evaluierung der anatomischen und funktionellen Langzeitergebnisse der photodynamischen Therapie (PDT) bei Patienten mit symptomatischen chorioidalen Hämangiomen.

Patienten und Methoden

Bei allen 8 Patienten hatten die Tumore zu einem Visusabfall geführt. Für die PDT wurde eine Verteporfin-Dosis von 6 mg/m2 Körperoberfläche und eine Lichtdosis von 100 J/cm2 bei 692 nm verwandt. Es wurden 2–4 Behandlungen in 6-wöchigen Intervallen durchgeführt. Standardisierte Untersuchungen erfolgten vor und 6 Wochen nach jeder Behandlung sowie nach 3, 6 und 12 Monaten. Anschließend wurden die Kontrollintervalle bis zu 1 Jahr gestreckt.

Ergebnisse

Alle Patienten zeigten nach 2–4 Behandlungen eine vollständige Regression des Angioms. Die Tumorhöhe wurde von durchschnittlich 3,64 mm auf nicht nachweisbar reduziert. Bei einem Auge fand sich ein stabiler Visusverlauf, bei 7 Augen ein Visusgewinn. Die Mikroperimetrieuntersuchungen zeigten einen Rückgang der zentralen Skotome. Bei keinem Patienten kam es zu einem Tumorrezidiv.

Schlussfolgerung

Die Langzeitergebnisse zeigen, dass die PDT eine effektive und sichere Behandlungsmethode ist. Die vollständige Tumorregression ist verbunden mit guten funktionellen und anatomischen Verläufen.

Abstract

Aim

Evaluation of functional and anatomical long-term results of patients with symptomatic choroidal hemangioma treated with photodynamic therapy (PDT).

Patients and methods

All 8 patients suffered from progressive loss of vision caused by exudation into the macular area. PDT with a verteporfin dose of 6 mg/m2 body surface area and a light dose of 100 J/cm2 at 692 nm was carried out. Two to four treatments were applied at 6 week intervals using a single laser spot. Standardized evaluation was used before and at 6-week intervals after each treatment and at 3, 6 and 12 months. In the further follow-up control intervals were extended up to 1 year in the case of stable anatomical and functional results.

Results

All patients showed complete regression of the tumor. The tumor height was reduced from an average of 3.64 mm to undetectable. One patient showed a stable visual acuity, seven patients a significant increase. Central scotometry showed withdrawal of scotomas from the macula. No patient showed any sign of recurrence during the follow-up of up to 60 months.

Conclusion

The long-term results of patients with active choroidal hemangioma demonstrate that PDT is a most effective and safe treatment option. Complete tumor regression is combined with good functional recovery.

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Literatur

  1. Anand R, Augsburger JJ, Shields JA (1989) Circumscribed choroidal hemangiomas. Arch Ophthalmol 107:1338–1342

    CAS  PubMed  Google Scholar 

  2. Augsburger JJ, Shields JA, Moffat KP (1981) Circumscribed choroidal hemangiomas: long-term visual prognosis. Retina 1:56–61

    Google Scholar 

  3. Barbazetto I, Schmidt-Erfurth U (2000) Photodynamic therapy of choroidal hemangioma: two case reports. Graefes Arch Clin Exp Ophthalmol 238:214–221

    Article  CAS  PubMed  Google Scholar 

  4. Duquesne N, Bouchard O, Jean-Louis B et al. (2002) Argon laser photocoagulation of circumscribed choroidal hemangiomas. J Fr Ophthalmol 25:42–47

    CAS  Google Scholar 

  5. Garcia-Arumi J, Ramsay LS, Guraya BC (2000) Transpupillary thermotherapy for circumscribed choroidal hemangiomas. Ophthalmology 107:351–357

    Article  CAS  PubMed  Google Scholar 

  6. Jurklies B, Anastassiou G, Ortmans S et al. (2003) Photodynamic therapy using Verteporfin in circumscribed choroidal hemangioma. Br J Ophthalmol 87:84–89

    Article  CAS  PubMed  Google Scholar 

  7. Madreperla SA (2001) Choroidal hemangioma treated with photodynamic therapy using verteporfin. Arch Ophthalmol 119:1606–1610

    CAS  PubMed  Google Scholar 

  8. Madreperla SA, Hungerford JL, Plowman PN et al. (1997) Choroidal hemangiomas. Ophthalmology 104:1773–1779

    CAS  PubMed  Google Scholar 

  9. Madreperla SA, Hungerford JL, Plowman PN et al. (1997) Choroidal hemangiomas. Visual and anatomic results of treatment by photocoagulation or radiation therapy. Ophthalmology 104:1773–1779

    CAS  PubMed  Google Scholar 

  10. Othmane IS, Shields CL, Shields JA et al. (1999) Circumscribed choroidal hemangioma managed by transpupillary thermotherapy. Arch Ophthalmol 117:136–137

    CAS  PubMed  Google Scholar 

  11. Porrini G, Giovannini A, Amato G et al. (2003) Photodynamic therapy of circumscribed choroidal hemangioma. Ophthalmology 110:674–680

    Article  PubMed  Google Scholar 

  12. Sanborn GE, Augsburger JJ, Shields JA (1982) Treatment of circumscribed choroidal hemangiomas. Ophthalmology 89:1374–1380

    CAS  PubMed  Google Scholar 

  13. Schilling H, Sauerwein W, Lommatzsch A et al. (1997) Long-term results after low dose ocular irradiation for choroidal hemangiomas. Br J Ophthalmol 81:267–273

    CAS  PubMed  Google Scholar 

  14. Schmidt-Erfurth U (1999) Indocyanine green angiography and retinal sensitivity after photodynamic therapy of subfoveal choroidal neovascularization. Sem Ophthalmol 14:35–44

    CAS  Google Scholar 

  15. Schmidt-Erfurth U, Bauman W, Gragoudas E et al. (1994) Photodynamic therapy of experimental choroidal melanoma using lipoprotein-delivered Benzoporphyrin. Ophthalmology 101:89–99

    CAS  PubMed  Google Scholar 

  16. Schmidt-Erfurth U, Laqua H, Schlötzer-Schrehardt U et al. (2002) Histopathological changes following photodynamic therapy in human eyes. Arch Ophthalmol 120:835–844

    PubMed  Google Scholar 

  17. Schmidt-Erfurth U, Michels S, Barbazetto I et al. (2002) Photodynamic effects on choroidal neovascularization and physiological choroid. Invest Ophthalmol 43:830–841

    PubMed  Google Scholar 

  18. Schmidt-Erfurth U, Michels S, Kusserow C et al. (2002) Photodynamic therapy for symptomatic choroidal hemangioma. Ophthalmology 109:2284–2294

    Article  PubMed  Google Scholar 

  19. Shields CL, Shields JA, De Potter P (1995) Patterns of indocyanine green videoangiography of choroidal tumors. Br J Ophthalmol 79:237–245

    CAS  PubMed  Google Scholar 

  20. TAP Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin. Report #1. Treatment of Age-related Macular Degeneration with Photodynamic Therapy (TAP) Study Group. Arch Ophthalmol 117:1329–45.

    PubMed  Google Scholar 

  21. TAP Study Group (2001) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin. Report #2. TAP Study Group. Arch Ophthalmol 119:198–207

    PubMed  Google Scholar 

  22. Witschel H, Font RL (1976) Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature. Surv Ophthalmol 20:415–431

    CAS  PubMed  Google Scholar 

  23. Zografos L, Bercher L, Chamot L et al. (1996) Cobalt-60 treatment of choroidal hemangiomas. Am J Ophthalmol 121:190–199

    CAS  Google Scholar 

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Authors and Affiliations

  1. Augenklinik des Universitätsklinikums Schleswig-Holstein, Lübeck

    S. Michels, R. Michels, A. Beckendorf & U. Schmidt-Erfurth

  2. Augenklinik des Universitätsklinikums Schleswig-Holstein, Ratzeburger Allee 160, 23538 , Lübeck

    S. Michels

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  1. S. Michels
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  2. R. Michels
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  4. U. Schmidt-Erfurth
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Correspondence to S. Michels.

Additional information

Ein Erratum zu diesem Beitrag können Sie unter http://dx.doi.org/10.1007/s00347-004-1087-0 finden.

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Michels, S., Michels, R., Beckendorf, A. et al. Photodynamische Therapie bei chorioidalen Hämangiomen. Ophthalmologe 101, 569–575 (2004). https://doi.org/10.1007/s00347-003-0914-z

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