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World Journal of Urology

, Volume 18, Issue 1, pp 2–9 | Cite as

Biomaterials for tissue engineering

  • Byung-Soo Kim
  • Carlos E. Baez
  • Anthony Atala
Article

Abstract

Biomaterials play a critical role in the engineering of new functional genitourinary tissues for the replacement of lost or malfunctioning tissues. They provide a temporary scaffolding to guide new tissue growth and organization and may provide bioactive signals (e.g., cell-adhesion peptides and growth factors) required for the retention of tissue-specific gene expression. A variety of biomaterials, which can be classified into three types – naturally derived materials (e.g., collagen and alginate), acellular tissue matrices (e.g., bladder submucosa and small-intestinal submucosa), and synthetic polymers [e.g., polyglycolic acid, polylactic acid, and poly(lactic-co-glycolic acid)] – have proved to be useful in the reconstruction of a number of genitourinary tissues in animal models. Some of these materials are currently being used clinically for genitourinary applications. Ultimately, the development or selection of appropriate biomaterials may allow the engineering of multiple types of functional genitourinary tissues.

Keywords

Polymer Peptide Tissue Engineering Lost Polylactic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Byung-Soo Kim
    • 1
  • Carlos E. Baez
    • 1
  • Anthony Atala
    • 1
  1. 1.Laboratory for Tissue Engineering and Cellular Therapeutics, Department of Urology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA e-mail: atala@a1.tch.harvard.edu Tel: +1-617-3556169; Fax: +1-617-3556587US

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