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Association of low-dose aspirin use for primary prevention with self-reported kidney stones prevalence: a cross-sectional study

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Abstract

Objective

To investigate the association between low-dose aspirin use for primary prevention and self-reported kidney stones prevalence in the 40–79 years old population.

Methods

We conducted a cross-sectional study based on the United States population data from the National Health and Nutrition Examination Survey 2011–2018. Baseline demographical and clinical data were collected. The univariate and multivariate regression was performed to identify confounding factors and assess the relationship between aspirin use for primary prevention and the prevalence of self-reported kidney stones. A propensity-score matching was used to identify patients with similar baseline characteristics to adjust for the bias caused by confounding factors.

Results

A total of 10,256 low-dose aspirin-use participants were included in this study. 10.4% of participants reported a history of kidney stones, and 18.5% reported a continuous use of low-dose prophylactic aspirin. Multivariate logistic regression analysis showed that low-dose preventive aspirin use had significantly increased the odds of self-reported kidney stones (OR = 1.245; 95% CI: 1.063–1.459; p = 0.007). In subgroup analysis, this finding was primarily limited to males (OR = 1.311), non-hypertensive participants (OR = 1.443), diabetic participants (OR = 1.380), and older (60 ≤ Age < 80) (OR = 1.349). The propensity-score matched analyses supported this result after adjusting for the bias caused by potential confounders (OR = 1.216; 95% CI: 1.011–1.462; p = 0.038).

Conclusion

In this study, there exists a significant relationship between low-dose aspirin for primary prevention and self-reported kidney stones, primarily among males, no hypertensive participants, diabetics, or older adults. Further studies are needed to elucidate the mechanisms underlying these findings in the future.

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Data availability

The datasets generated during the current study are available in the public database (NHANES) [https://www.cdc.gov/nchs/nhanes/].

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Author information

Author notes

  1. Yingji Chen and Fang Huang have contributed equally to this work and share correspondence authorship.

Authors and Affiliations

  1. Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

    Miaomiao Yang

  2. Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China

    Yongchao Li & Fang Huang

  3. Department of Cardiothoracic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

    Yingji Chen

  4. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China

    Fang Huang

Authors
  1. Miaomiao Yang
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  4. Fang Huang
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Contributions

MY: Conceptualization, Visualization, Methodology, Writing an original draft. YL: Investigation, Resources. YC: Methodology, Software, Formal analysis. FH: Conceptualization, Project administration, Supervision.

Corresponding authors

Correspondence to Yingji Chen or Fang Huang.

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The authors declare no conflicts of interest.

Ethics approval

The study involving human participants was reviewed and approved by The Wake Forest School of Medicine Institutional Review Board. The participants provided their written informed consent to participate in this study.

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Yang, M., Li, Y., Chen, Y. et al. Association of low-dose aspirin use for primary prevention with self-reported kidney stones prevalence: a cross-sectional study. World J Urol 41, 3753–3758 (2023). https://doi.org/10.1007/s00345-023-04657-9

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  • DOI: https://doi.org/10.1007/s00345-023-04657-9

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