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Anxiety and depression in association with lower urinary tract symptoms: results from the COBaLT study

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Abstract

Purpose

Depression and anxiety have been associated with lower urinary tract symptoms (LUTS) in several studies. In our population, the prevalence of LUTS is high, consequently, it is essential and an objective of this study, to determine the association between anxiety, depression, and LUTS in a large Hispanic population.

Methods

A sub-analysis of a cross‐sectional population‐based study to estimate LUTS prevalence in the Colombian population was performed (COBaLT study) (Plata et al. in Neurourol Urodyn 38:200–207, 2018). The Hospital Anxiety and Depression Scale (HADS) was used to evaluate mental health. Logistic regression was carried out to estimate the association of depression and anxiety with different LUTS. Variables that proved statistically significant (p < 0.05) were included in a multivariate model.

Results

A total of 1060 individuals were assessed. The prevalence of anxiety in women and men was 17.1% and 6.7%, respectively. Depression in women and men was 20.1% and 9.4%, respectively. An association was found between anxiety and overactive bladder (OAB) without urinary incontinence (OR = 3.7) and moderate or severe LUTS in men (OR = 3.8). In women, anxiety was associated with nocturia (OR = 4.2) and stress urinary incontinence (OR = 2.4). For depression, an association was found between sexual dysfunction (OR = 4.3) and moderate or severe LUTS (OR = 4.0) in men; while in women it was associated with stress urinary incontinence (OR = 2.3), the sensation of incomplete emptying (OR = 1.7) and decreased frequency of sexual activity (OR = 1.8).

Conclusions

The associations found are consistent with other reports. It is essential to inquire about possible symptoms related to the mental sphere in the urology consultation to make appropriate referrals and subsequent management.

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Data availability

Data available on request from the authors.

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Funding

No funding was received for conducting this study.

Author information

Authors and Affiliations

  1. Department of Urology, Hospital Universitario Fundación Santa Fe de Bogotá and Universidad de Los Andes School of Medicine, Carrera 7 No. 118-09, Unidad Renal, Piso 3, Bogotá, D.C., Colombia

    Laura Zuluaga, Juan Ignacio Caicedo, María Paula Mogollón, Jessica Santander, Alejandra Bravo-Balado, Carlos Gustavo Trujillo, César Diaz Ritter & Mauricio Plata

  2. Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, 110111, Bogotá, D.C., Colombia

    Martín Rondón

Authors
  1. Laura Zuluaga
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  2. Juan Ignacio Caicedo
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  3. María Paula Mogollón
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  4. Jessica Santander
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  5. Alejandra Bravo-Balado
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  6. Carlos Gustavo Trujillo
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  7. César Diaz Ritter
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  8. Martín Rondón
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  9. Mauricio Plata
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Contributions

LZ: data analysis, manuscript writing, manuscript editing. JIC: manuscript writing, manuscript editing. MPM: data analysis, manuscript writing. JS: manuscript writing. AB-B: protocol development, protocol development, data collection. CGT: manuscript editing. CAD: manuscript writing, manuscript editing. MR: data analysis, data management. MP: manuscript editing. We confirm that all the authors listed above contributed, read, and approved the submitted material. Material preparation, data collection and analysis were performed by Alejandra Bravo-Balado, Laura Zuluaga, Martin Rondon and Maria Paula Mogollon. The first draft was written by Laura Zuluaga and Maria Paula Mogollon. Review and editing were made by Jessica Santander, Juan Ignacio Caicedo, Mauricio Plata and Carlos Trujillo. The final draft and edition were made by Cesar Alejandro Diaz and Laura Zuluaga.

Corresponding author

Correspondence to Juan Ignacio Caicedo.

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Conflict of interest

The authors declare no conflict of interest. The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

The original study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Fundación Santa Fe de Bogotá (CCEI–3263‐2015).

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Verbal informed consent was obtained prior to the interview.

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Zuluaga, L., Caicedo, J.I., Mogollón, M.P. et al. Anxiety and depression in association with lower urinary tract symptoms: results from the COBaLT study. World J Urol 41, 1381–1388 (2023). https://doi.org/10.1007/s00345-023-04351-w

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  • DOI: https://doi.org/10.1007/s00345-023-04351-w

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