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Incidence of bladder cancer in neuro-urological patients in France: a nationwide study

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Abstract

Purpose

The purpose of this study was to evaluate the incidence of bladder cancer (BCa) in patients with the main neurological diseases that induce neurogenic lower urinary tract dysfunction, namely, multiple sclerosis (MS), spinal cord injury (SCI) and spina bifida (SB).

Methods

We conducted a retrospective analysis of nationwide data from the French Hospital Discharge Database (PMSI) from January 2010 to December 2018. The incidence of BCa was calculated in patients with MS, SCI and SB. Incidence, sex, age, radical cystectomy after BCa diagnosis and in-hospital deaths were compared between the three groups. The Chi2 and Kruskal–Wallis tests were used for qualitative and quantitative data comparisons, respectively.

Results

Overall, 2015 neuro-urological patients (mean (± SD) age: 65.4 ± 12.3 years) were hospitalized in France between 2010 and 2018 with a new diagnosis of BCa. In neuro-urological patients, BCa was more frequent in men than in women (sex ratio: 3.08). The incidence of BCa in neuro-urological patients was 174.9/100,000 persons/year. The incidence of BCa was 791.1/100,000 persons/year in SCI compared to 56.6 in MS and 113.8 in SB (p < 0.0001). After the initial diagnosis of BCa, 551 (27.3%) patients underwent a radical cystectomy and 613 (30.4%) died in hospital after BCa diagnosis.

Conclusions

The incidence of BCa in France between 2010 and 2018 was 174.9/100 000 persons/year, and was particularly high in patients with SCI.

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Data availability

The authors declare that all data support published claims and comply with field standards.

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The authors declare that all materials as well as software application or custom codes support published claims and comply with field standards.

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Funding

No funding was received for this study.

Author information

Authors and Affiliations

  1. Department of Urology and Kidney Transplantation, Assistance Publique-Hôpitaux de Marseille, La Conception Hospital, Aix-Marseille University, 147 boulevard Baille, 13005, Marseille, France

    Floriane Michel & Gilles Karsenty

  2. GRC5 Predictive Onco-urology AP-HP, Sorbonne University, Paris, France

    Floriane Michel, Fabiana Cancrini, Olivier Cussenot, Morgan Rouprêt & Véronique Phé

  3. Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, Sapienza University of Rome, Rome, Italy

    Fabiana Cancrini

  4. Department of Urology, CHU de Bordeaux, Bordeaux, France

    Henri Bensadoun

  5. Department of Urology, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France

    Olivier Cussenot & Véronique Phé

  6. Department of Urology, Foch Hospital, Suresnes, France

    Cyrille Guillot-Tantay

  7. Department of Urology, Pitié-Salpêtrière Academic Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France

    Morgan Rouprêt

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  1. Floriane Michel
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Contributions

FM contributed to protocol/project development, data collection or management, data analysis and manuscript writing/editing; FC, OC, CG-T and MR were involved in manuscript writing/editing; HB was involved in protocol/project development and data collection or management; GK contributed to protocol/project development and manuscript writing/editing; VP was involved in protocol/project development, data analysis and manuscript writing/editing.

Corresponding author

Correspondence to Floriane Michel.

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Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

According to all relevant laws, regulations and codes of practice in France, authorization was obtained from the Hospital Information Technical Agency (Agence Technique de l’Information sur l’Hospitalisation; ATIH) and National Commission on Information Technology and Civil Liberties (Commission Nationale de l’Informatique et des Libertés; CNIL) to extract anonymous data from the PMSI and to perform this study, in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Due to the retrospective nature of the study and the anonymization of this register, informed consent was not required.

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Michel, F., Cancrini, F., Bensadoun, H. et al. Incidence of bladder cancer in neuro-urological patients in France: a nationwide study. World J Urol 40, 1921–1927 (2022). https://doi.org/10.1007/s00345-022-03955-y

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  • DOI: https://doi.org/10.1007/s00345-022-03955-y

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