Skip to main content

Racial/ethnic disparities in survival of metastatic prostate cancer patients treated with external beam radiotherapy

The Original Article was published on 12 May 2021

Dear Editor

We read the study by Würnschimmel et al. [1] with great interest and would like to congratulate the authors for their superb study. The authors assessed the effect of race/ethnicity in cancer-specific mortality adjusted for other-cause mortality in metastatic prostate cancer patients (mPCa) treated with external beam radiotherapy to the prostate.

  1. 1.

    The factors extracted by the researchers from the SEER database (2004–2016) include clinical T stage and clinical N stage. However, according to the SEER Program [2], the “clinical stage” variable was not provided in the dataset until 2016. Therefore, for patients diagnosed before 2016, it was impossible for authors to identify the clinical stage. How to obtain the clinical stage of patients diagnosed between 2004 and 2016 needs to be explained in detail.

  1. 2.

    Some of the patients included in the analysis received chemotherapy. This type of treatment should be taken into consideration since prior literature showed that chemotherapy holds great potential in the management of mPCa patients [3, 4].

  2. 3.

    Patients diagnosed with primary mPCa were included in this study, but multiple primary cancers were not excluded. However, another SEER-based study showed mPCa patients were at a significantly higher risk of developing a second malignancy, which may affect patients’ survival [5].

Availability of data and materials

Not applicable.

Code availability

Not applicable.

References

  1. 1.

    Würnschimmel C, Wenzel M, Collà Ruvolo C, Nocera L, Tian Z, Saad F, Briganti A, Shariat SF, Mandel P, Chun FKH, Tilki D, Graefen M, Karakiewicz PI (2021) Survival advantage of Asian metastatic prostate cancer patients treated with external beam radiotherapy over other races/ethnicities. World J Urol. https://doi.org/10.1007/s00345-021-03720-7

    Article  PubMed  Google Scholar 

  2. 2.

    Ruhl J, Adamo M, Dickie L (2016) SEER program coding and staging manual 2016: section V. National Cancer Institute, Bethesda, MD, pp 20850–29765

    Google Scholar 

  3. 3.

    Quinn DI, Sandler HM, Horvath LG, Goldkorn A, Eastham JA (2017) The evolution of chemotherapy for the treatment of prostate cancer. Ann Oncol 28(11):2658–2669. https://doi.org/10.1093/annonc/mdx348

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Saad F (2015) Prostate cancer in 2014: the year chemotherapy finally gets some respect! Nat Rev Urol 12(2):71–72. https://doi.org/10.1038/nrurol.2014.362

    Article  PubMed  Google Scholar 

  5. 5.

    Davis EJ, Beebe-Dimmer JL, Yee CL, Cooney KA (2014) Risk of second primary tumors in men diagnosed with prostate cancer: a population-based cohort study. Cancer 120(17):2735–2741. https://doi.org/10.1002/cncr.28769

    Article  PubMed  Google Scholar 

Download references

Funding

None.

Author information

Affiliations

Authors

Contributions

WY: reviewed the relevant study and drafted this letter. JG: revised this letter for critical content and scientific rigour.

Corresponding author

Correspondence to Jun Guo.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

Not applicable.

Informed consent

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yu, W., Guo, J. Racial/ethnic disparities in survival of metastatic prostate cancer patients treated with external beam radiotherapy. World J Urol (2021). https://doi.org/10.1007/s00345-021-03859-3

Download citation