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Mirabegron in medical expulsive therapy for distal ureteral stones: a prospective, randomized, controlled study

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A Letter to the Editor to this article was published on 12 January 2022

Abstract

Objective

To observe the efficacy and safety of Mirabegron in patients with distal, ureteral stones ≤ 10 mm.

Patients and methods

A total of 90 patients with distal ureteral stones ≤ 10 mm were prospectively randomized into two groups. Forty-five cases in the study group and 45 cases as control. The stone-free rates (SFRs) and renal colic episodes between two groups were compared at the 1st, 2nd and 4th week end by imaging examinations.

Result

All of 90 patients were randomly assigned to two groups. In patients with ≤ 5 mm stones, the SFRs in the 1st week (63.6% vs. 33.3%, P = 0.040), the 2nd week (86.4% vs. 54.2%, P = 0.018), and the 4th week (90.9% vs. 66.7%, P = 0.046) after treatment were all significantly higher than that in the control group by the stratification analysis of stone size. Even though SFRs were all higher for patients with > 5 mm stones in study group, there was no statistically significant difference (All P > 0.05). In terms of renal colic episodes, the frequency of occurrence of the study group was significantly lower than that of the control group and need less antalgic.

Conclusions

The MET with Mirabegron has a significant role in improve SFR for the patients with distal ureteral stones ≤ 5 mm and no effect in > 5 mm stones. Furthermore, Mirabegron reduces the need for antalgic in ≤ 10 mm stones with low incidence of adverse effects.

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Funding

This study received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Nanjing Jiangning Hospital, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China

    Qing-lai Tang, Du-jian Wang, Shuang Zhou & Rong-zhen Tao

Authors
  1. Qing-lai Tang
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  2. Du-jian Wang
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  3. Shuang Zhou
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  4. Rong-zhen Tao
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Contributions

Q-LT: project development; SZ: data collection; RZT and D-JW: data analysis and manuscript writing.

Corresponding author

Correspondence to Rong-zhen Tao.

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Conflict of interest

The authors declare that they have no competing financial interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of Affiliated Jiangning Hospital with Nanjing Medical University and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Tang, Ql., Wang, Dj., Zhou, S. et al. Mirabegron in medical expulsive therapy for distal ureteral stones: a prospective, randomized, controlled study. World J Urol 39, 4465–4470 (2021). https://doi.org/10.1007/s00345-021-03772-9

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  • DOI: https://doi.org/10.1007/s00345-021-03772-9

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