Abstract
Purpose
To clarify the role of Trp64Arg polymorphisms of the gene encoding the β3-adrenoceptor for lower urinary tract function in males, the present study investigated the association between the Trp64Arg polymorphisms and lower urinary tract symptoms (LUTS) and function.
Methods
This prospective observational study included patients who underwent robot-assisted radical prostatectomy. Before surgery, blood samples were collected, and analyses of β3-adrenoceptor gene polymorphism were performed using the real-time polymerase chain reaction. The present cohort was divided into patients with wild type (Trp64Trp) and with variant type (Trp64Arg + Arg64Arg), and LUTS and lower urinary tract function before surgery were compared between them.
Results
Wild type was found in 247 patients, with variant type in 129. There were no significant differences in LUTS between the two groups. Residual urine volume (PVR) (wild type: variant type = 47 ± 53 mL: 58 ± 77 mL, P = 0.04) and voiding time on uroflowmetry (wild type: variant type = 29 ± 15 s: 33 ± 17 s, P = 0.04) were significantly increased in the variant type.
Conclusion
The Trp64Arg variant of the β3-adrenoceptor gene significantly increased PVR and voiding time in men. However, it was not significantly associated with the emergence of LUTS. Thus, since the effect of β3-adrenoceptor gene polymorphisms on the genitourinary organs might be weak, whether men possess the Trp64Arg variant of the β3-adrenoceptor gene might not critically affect urinary quality of life, but modestly affect the lower urinary tract function.
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NH contributed to the writing of the original draft. YO contributed to the supervision. TM contributed to the editing the draft. KT contributed to the editing the draft. HA contributed to the conceptualization. JH contributed to the data analyses. RH contributed to the data collection. KM contributed to the data collection. SO contributed to the producing the figures and tables. YK contributed to the supervision.
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We have no conflict of interest. The study protocol was approved by the ethics committee at our institution (clinical trial registration number 2438). The study protocol followed the ethical guidelines of the 1975 Declaration of Helsinki.
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Informed consent was obtained from all subjects.
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Haga, N., Okabe, Y., Miyazaki, T. et al. The effect of β3-adrenoceptor gene polymorphisms on lower urinary tract function in males. World J Urol 39, 3035–3040 (2021). https://doi.org/10.1007/s00345-020-03531-2
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DOI: https://doi.org/10.1007/s00345-020-03531-2