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Role of multiparametric magnetic resonance imaging to predict postoperative Gleason score upgrading in prostate cancer with Gleason score 3 + 4

Abstract

Background

To evaluate the role of multiparametric magnetic resonance imaging (mpMRI) in Gleason score (GS) 3 + 4 prostate cancer (PCa) and evaluate independent factors in mpMRI that can predict GS upgrading, we compared the outcomes of GS upgrading group and GS non-upgrading group.

Patients and methods

We analyzed the data of 539 patients undergoing radical prostatectomy (RP) for biopsy GS 3 + 4 PCa from two tertiary referral centers. Univariate and multivariate analyses were performed to determine significant predictors of GS upgrading. GS upgrading, the study outcome, was defined as GS ≥ 4 + 3 at definitive pathology at RP specimen.

Results

GS upgrading rate was 35.3% and biochemical recurrence (BCR) rate was 8.0%. GS upgrading group was significantly older (p = 0.015), had significantly higher prebiopsy serum prostate-specific antigen (PSA) level (p = 0.001) and PSA density (p = 0.003), had a higher number of prostate biopsy (p = 0.026). There were 413 lesions (76.6%) of PI-RADS lesion ≥ 4, 236 (57.1%) for PI-RADS 4 and 177 (42.9%) for PI-RADS 5 lesion. Multivariate logistic regression analysis revealed that age (p = 0.045), initial prebiopsy PSA level (p = 0.002) and presence of PI-RADS lesion ≥ 4 (p = 0.044) are independent predictors of GS upgrading.

Conclusion

MpMRI can predict postoperative Gleason score upgrading in prostate cancer with Gleason score 3 + 4. Especially, presence of clinically significant PI-RADS lesion ≥ 4, the significant predictor of GS upgrading, in preoperative mpMRI needs to be paid attention and can be helpful for patient counseling on prostate cancer treatment.

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Authors

Contributions

HK and SKH contributed to protocol/project development; CWJ, JHK, CK, and SKH were involved in data collection or management; HK, JKK, and SKH analyzed the data; HK and SKH contributed to manuscript writing/editing; HK, JKK, and SKH were involved in critical review; SKH supervised the study.

Corresponding author

Correspondence to Sung Kyu Hong.

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There are no conflicts of interest, including specific financial interests, relationships, and affiliations relevant to the subject materials described in this manuscript.

Ethical statement

All study protocols were in accordance with the principles of the Helsinki Declaration. We removed personal identifiers and anonymized all data, which exempted the study from the need to obtain informed consent from patients.

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Kim, H., Kim, J.K., Hong, S.K. et al. Role of multiparametric magnetic resonance imaging to predict postoperative Gleason score upgrading in prostate cancer with Gleason score 3 + 4. World J Urol 39, 1825–1830 (2021). https://doi.org/10.1007/s00345-020-03421-7

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Keywords

  • Prostate cancer
  • Multiparametric MRI
  • Gleason score 3 + 4
  • Radical prostatectomy
  • Gleason score upgrading
  • Prostate biopsy