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Altered gut microbiome associated with overactive bladder and daily urinary urgency

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World Journal of Urology Aims and scope Submit manuscript

Abstract

Purpose

To explore associations between the gut microbiome and overactive bladder (OAB) with daily urinary urgency among individuals reporting this diagnosis within a single community.

Methods

This cross-sectional study surveyed 1113 individuals who participated in the Iwaki Health Promotion Project in Japan. OAB was defined as urinary urgency at least once per week and an Overactive Bladder Symptom Score (OABSS) of ≥ 3. OAB with urinary urgency at least once a day was defined as daily urgency. The gut microbiomes were assessed by next-generation sequencing of 16S rRNA genes extracted from fecal samples. The participants were divided into two groups: OAB-daily urgency and non-OAB. Cases were selected for inclusion on the basis of 1:1 propensity score matching; we assigned 58 individuals to each group (23 men and 35 women) for our analysis.

Results

Individuals reporting OAB with daily urinary urgency demonstrated a lower bacterial diversity between individuals (Bray–Curtis distance 0.48 vs. 0.53, P < 0.001); the results cluster differently in the non-OAB groups. The relative abundance of genus Bifidobacterium was significantly lower among those reporting daily urgency (2.41% vs. 4.23%, P = 0.014). By contrast, the relative abundance of genus Faecalibacterium (9.25% vs. 6.26%, P = 0.006) was significantly higher in this group.

Conclusion

We observed significant differences in gut microbial contents and specific bacterial genera in association with OAB with daily urgency. Further study will be necessary to assess causal relationships between the gut microbiome and OAB.

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Acknowledgements

We would like to thank Ippei Takahashi, Shizuka Kurauchi, Yuki Fujita, Yukie Nishizawa, Satomi Sakamoto, and the entire staff of the Department of Social Medicine in Hirosaki University for their invaluable help with the collection of data. This work was supported by JST COI Grant Number JPMJCE1302. The authors would also like to thank Enago (https://www.enago.jp) for the English language review.

Funding

This work was supported by a Grant-in-Aid for Scientific Research (Grant Nos. 18K16682 and 18K16717) from the Japan Society for the Promotion of Science.

Author information

Authors and Affiliations

  1. Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

    Teppei Okamoto, Shingo Hatakeyama, Atsushi Imai, Hayato Yamamoto, Kazuyuki Mori, Takahiro Yoneyama & Chikara Ohyama

  2. Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

    Tohru Yoneyama, Yasuhiro Hashimoto & Chikara Ohyama

  3. Department of Social Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan

    Shigeyuki Nakaji

Authors
  1. Teppei Okamoto
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  2. Shingo Hatakeyama
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  3. Atsushi Imai
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Contributions

TO: data analysis, manuscript writing. SH: data analysis, manuscript editing. AI, HY, TY, KM, TY, and YH: data collection. SN and CO: project development.

Corresponding author

Correspondence to Shingo Hatakeyama.

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Conflict of interest

All authors declare that they have no conflicts of interest.

Research involving human participants and/or animals

The study was conducted following the ethical guidelines of the Declaration of Helsinki, and the use of data from the Iwaki Health Promotion Project was approved by the Ethics Committee of Hirosaki University School of Medicine (authorization number 2018-062).

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All participants voluntarily provided written informed consent.

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345_2020_3243_MOESM1_ESM.pptx

Supplementary file1. Figure S1. LEfSe analysis between the participants with depressive status (SF-36 MH < 52.0) and those without. The genera of Parabacteroides and Oscillibacter were overrepresented in the participants with depressive status. (PPTX 62 kb)

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Okamoto, T., Hatakeyama, S., Imai, A. et al. Altered gut microbiome associated with overactive bladder and daily urinary urgency. World J Urol 39, 847–853 (2021). https://doi.org/10.1007/s00345-020-03243-7

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  • DOI: https://doi.org/10.1007/s00345-020-03243-7

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