Abstract
Background
Radical cystectomy (RC) has a high morbidity and leads to a significant socio-economic burden. We aimed to investigate pre-, intra-, and post-operative variables to create a novel score predicting both post-operative clinical (complications) and economic (length of hospital stay) outcome after RC.
Methods
We retrospectively evaluated clinical and histopathological data of 317 patients after RC. We performed univariate and multivariate logistic regression analyses to identify variables associated with post-operative clinical (30-day morbidity according to Clavien–Dindo complications) and economic (length of hospital stay) outcome.
Results
In multivariate analysis, a high number of intraoperative transfusions (T) of packed red blood cells predicted major complications (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.10–2.58, p = 0.017), preoperative potassium (P) level predicted three or more complications (OR for high preoperative potassium 0.71, 95% CI 0.52–0.98, p = 0.037), and high drain (D) loss on post-operative day 1 predicted a longer hospital stay ≥ 22 days (OR 1.57, 95% CI 1.04–2.35, p = 0.003). The PT2D-Score was able to predict three or more complications (area under the curve: 0.70, 95% CI 0.61–0.78, p < 0.001) and a hospital stay of ≥ 22 days in patients after radical cystectomy (area under the curve: 0.63, 95% confidence interval 0.53–0.72, p = 0.012).
Conclusions
The novel PT2D-Score combines preoperative potassium level, intraoperative blood transfusion, and post-operative drain loss to predict both clinical (30-day morbidity) and economic (length of hospital stay) outcome for patients undergoing RC. After validation in a larger cohort, the novel PT2D-Score might serve as an additional criterion to identify patients for intensified monitoring after RC.
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References
Meyer CP, Hollis M, Cole AP, Hanske J, O'Leary J, Gupta S et al (2016) Complications following common inpatient urological procedures: temporal trend analysis from 2000 to 2010. Eur Urol Focus 2:3–9
Lee R, Chughtai B, Herman M, Shariat SF, Scherr DS (2011) Cost-analysis comparison of robot-assisted laparoscopic radical cystectomy (RC) vs open RC. BJU Int 108:976–983
Welty CJ, Sanford TH, Wright JL, Carroll PR, Cooperberg MR, Meng MV et al (2017) The cancer of the bladder risk assessment (COBRA) score: estimating mortality after radical cystectomy. Cancer 123:4574–4582
Le Manach Y, Collins G, Rodseth R, Le Bihan-Benjamin C, Biccard B, Riou B et al (2016) Preoperative score to predict postoperative mortality (POSPOM): derivation and validation. Anesthesiology 124:570–579
Froehner M, Koch R, Hubler M, Heberling U, Novotny V, Zastrow S et al (2017) Validation of the preoperative score to predict postoperative mortality in patients undergoing radical cystectomy. Eur Urol Focus 2:197–200
Novotny V, Froehner M, Koch R, Zastrow S, Heberling U, Leike S et al (2016) Age, American Society of Anesthesiologists physical status classification and Charlson score are independent predictors of 90-day mortality after radical cystectomy. World J Urol 34:1123–1129
Takada N, Abe T, Shinohara N, Sazawa A, Maruyama S, Shinno Y et al (2012) Peri-operative morbidity and mortality related to radical cystectomy: a multi-institutional retrospective study in Japan. BJU Int 110:E756–E764
Schulz GB, Grimm T, Buchner A, Jokisch F, Kretschmer A, Casuscelli J et al (2018) Surgical high-risk patients with ASA ≥3 undergoing radical cystectomy: morbidity, mortality, and predictors for major complications in a high-volume tertiary center. Clin Genitourin Cancer 6:e1141–e1149
Djaladat H, Bruins HM, Miranda G, Cai J, Skinner EC, Daneshmand S (2014) The association of preoperative serum albumin level and American Society of Anesthesiologists (ASA) score on early complications and survival of patients undergoing radical cystectomy for urothelial bladder cancer. BJU Int 113:887–893
Lavallee LT, Schramm D, Witiuk K, Mallick R, Fergusson D, Morash C et al (2014) Peri-operative morbidity associated with radical cystectomy in a multicenter database of community and academic hospitals. PLoS ONE 9:e111281
Prasad SM, Ferreria M, Berry AM, Lipsitz SR, Richie JP, Gawande AA et al (2009) Surgical apgar outcome score: perioperative risk assessment for radical cystectomy. J Urol 181:1046–1052 (discussion 52–53)
Gawande AA, Kwaan MR, Regenbogen SE, Lipsitz SA, Zinner MJ (2007) An Apgar Score for surgery. J Am Coll Surg 204:201–208
Regenbogen SE, Lancaster RT, Lipsitz SR, Greenberg CC, Hutter MM, Gawande AA (2008) Does the Surgical Apgar Score measure intraoperative performance? Ann Surg 248:320–328
Meng YS, Su Y, Fan Y, Yu W, Wang Y, Zheng W et al (2015) Risk factors for the development of postoperative paralytic ileus after radical cystectomy: a report of 740 cases. Beijing Da Xue Xue Bao Yi Xue Ban 47:628–633
Cerantola Y, Valerio M, Persson B, Jichlinski P, Ljungqvist O, Hubner M et al (2013) Guidelines for perioperative care after radical cystectomy for bladder cancer: enhanced recovery after surgery (ERAS((R))) society recommendations. Clin Nutr 32:879–887
Frees SK, Aning J, Black P, Struss W, Bell R, Chavez-Munoz C et al (2018) A prospective randomized pilot study evaluating an ERAS protocol versus a standard protocol for patients treated with radical cystectomy and urinary diversion for bladder cancer. World J Urol 36:215–220
Loffel LM, Burkhard FC, Takala J, Wuethrich PY (2016) Impact of a potassium-enriched, chloride-depleted 5% glucose solution on gastrointestinal function after major abdominopelvic surgery: results of a randomized controlled trial. Anesthesiology 125:678–689
Siemens DR, Jaeger MT, Wei X, Vera-Badillo F, Booth CM (2017) Peri-operative allogeneic blood transfusion and outcomes after radical cystectomy: a population-based study. World J Urol 35:1435–1442
Sui W, Onyeji IC, Matulay JT, James MB, Theofanides MC, Wenske S et al (2016) Perioperative blood transfusion in radical cystectomy: analysis of the national surgical quality improvement program database. Int J Urol 23:745–750
Higgins RM, Helm MC, Kindel TL, Gould JC (2019) Perioperative blood transfusion increases risk of surgical site infection after bariatric surgery. Surg Obes Relat Dis 15:582–587
Wang YL, Jiang B, Yin FF, Shi HQ, Xu XD, Zheng SS et al (2015) Perioperative blood transfusion promotes worse outcomes of bladder cancer after radical cystectomy: a systematic review and meta-analysis. PLoS ONE 10:e0130122
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Kamal, M.M., Borgmann, H., Metzger, A. et al. The PT2D-Score: a novel tool to predict complications and economic outcome after radical cystectomy. World J Urol 38, 3155–3160 (2020). https://doi.org/10.1007/s00345-020-03129-8
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DOI: https://doi.org/10.1007/s00345-020-03129-8