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Cholecalciferol for the prophylaxis against recurrent urinary tract infection among patients with benign prostatic hyperplasia: a randomized, comparative study

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Abstract

Purpose

To explore the role of cholecalciferol for the prophylaxis against recurrent urinary tract infection (UTI) in patients with benign prostatic hyperplasia (BPH).

Methods

Our randomized, uncontrolled prospective study included 389 naïve BPH patients with moderate/severe symptoms, consecutively. The patients were randomly allocated to two groups; group-A included 193 patients who received tamsulosin, while group-B included another 196 patients who received tamsulosin with cholecalciferol. The study population was followed up for 2 years after the start of the treatment. For all the patients enrolled, clinical evaluation, imaging studies (abdominal and trans-rectal ultrasonography), and laboratory investigations [including urinalysis, urine culture with antibiotic susceptibility testing for positive cultures and estimation of prostate-specific antigen (PSA) level] were provided.

Results

The incidence rate of recurrent UTI was 9% among the study population; it was significantly higher among group-A patients compared to those of group-B (13.5% vs. 4.6%, p 0.003, OR 2.7, 95% CI 1.5–4.3). Compared to patients of group-A, those of group-B developed a significantly lower level of PSA at the end of treatment period (0.16 ± 0.03 ng/mL vs. 0.27 ± 0.08 ng/mL, p 0.043, OR 1.9, 95% CI 1.2–6.8).

Conclusions

Adjuvant cholecalciferol supplementation may be protective against recurrent UTI among patients with BPH receiving tamsulosin therapy without extra adverse effects.

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Abbreviations

BPH:

Benign prostatic hyperplasia

UTI:

Urinary tract infection

AUA-SI:

American Urological Association Symptom Index

PSA:

Prostate-specific antigen

PVR:

Post-void residue

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Authors and Affiliations

  1. Department of Urology and Nephrology Hospital, Assiut University, Assiut, 71516, Egypt

    Ahmed S. Safwat, Ahmed Shahat, Hazem Orabi & Mohamed Sayed

  2. Department of Tropical Medicine and Gastroenterology, Assiut University, Assiut, Egypt

    Ahmad Hasanain

  3. Department of Urology, South Valley University, Qena, Egypt

    Mostafa AbdelRazek

  4. Department of Medicine (Nephrology Unit), Assiut University, Assiut, Egypt

    Samir K. Abdul Hamid

  5. Department of Microbiology and Immunology, Assiut University, Assiut, Egypt

    Amany Nafee

  6. Department of Biochemistry, Assiut University, Assiut, Egypt

    Sally Bakkar

Authors
  1. Ahmed S. Safwat
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  2. Ahmad Hasanain
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  3. Ahmed Shahat
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  4. Mostafa AbdelRazek
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  5. Hazem Orabi
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  6. Samir K. Abdul Hamid
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  7. Amany Nafee
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  8. Sally Bakkar
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  9. Mohamed Sayed
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Contributions

ASS: project development, data collection, data analysis, and manuscript writing. AH: project development, data collection, data analysis, and manuscript writing. AS: data collection and manuscript writing. MA: manuscript revision and manuscript editing. HO: manuscript revision and manuscript editing. SKA: data collection and manuscript writing. AN: data collection and manuscript editing. SB: data collection and manuscript editing. MS: manuscript revision and manuscript editing.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Electronic supplementary material

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Supplementary Figure 1: Flow chart of the study cases with BPH

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Safwat, A.S., Hasanain, A., Shahat, A. et al. Cholecalciferol for the prophylaxis against recurrent urinary tract infection among patients with benign prostatic hyperplasia: a randomized, comparative study. World J Urol 37, 1347–1352 (2019). https://doi.org/10.1007/s00345-018-2536-8

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  • DOI: https://doi.org/10.1007/s00345-018-2536-8

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