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The effect of hexanic extract of Serenoa repens on prostatic inflammation: results from a randomized biopsy study

Abstract

Purpose

To evaluate the effect of hexanic extract of Serenoa repens (HESr) on prostatic inflammation in patients with diagnosed prostatic inflammation.

Methods

Patients with prostatic inflammation histologically confirmed by TRUS prostatic biopsy were randomized either to receive HESr (320 mg/day) or no treatment. A second biopsy was performed 6 months later according to standard clinical practice. Inflammation was assessed by the Irani’s score and immunohistochemical staining using the CD3, CD4 and CD8 (for T-leucocytes), CD20 (for B-leucocytes) and CD163 (for macrophages) antibodies.

Results

Overall 97 patients were eligible for analysis. In the HESr group the mean inflammation grading and aggressiveness grading score significantly decreased from 1.55 and 1.55 at baseline to 0.79 (p = 0.001) and 0.87 (p = 0.001) at the second biopsy, respectively. In the control group the mean inflammation grading score was 1.44 at first biopsy and 1.23 at the second biopsy. The mean aggressiveness gradings core was 1.09 and 0.89, respectively. No statistical significance was found (p = 0.09 and p = 0.74).The mean decrease in all inflammation scores was statistically higher in the HESr patients compared to controls. The immunohistochemical staining showed a significant change in the expression of the analyzed antibodies for the HESr patients compared to the first biopsy. In the nontreatment group, no significant difference was found at the second biopsy. The change in expression of each antibody in the HESr group was statistical significant compared to control.

Conclusions

HESr seems to reduce prostatic inflammation in terms of histological and immunohistochemical parameters in this specific patients population.

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Authors and Affiliations

Authors

Contributions

SG: protocol and project development, data collection, data analysis, manuscript editing. MS: data collection, data analysis, manuscript writing. KZ: data collection and management. AK: data collection. GK: data collection and management, manuscript editing. VT: data collection. MM: data collection and management, manuscript editing.

Corresponding author

Correspondence to Stavros Gravas.

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Conflict of interest

Stavros Gravas has received speaker honoraria from Astellas, Pierre Fabre Medicament and consultancy honoraria from Astellas and GSK. Michael Samarinas, Konstantina Zacharouli, Anastasios Karatzas, Georgios Koukoulis, Vasileios Tzortzis, Michael Melekos declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Gravas, S., Samarinas, M., Zacharouli, K. et al. The effect of hexanic extract of Serenoa repens on prostatic inflammation: results from a randomized biopsy study. World J Urol 37, 539–544 (2019). https://doi.org/10.1007/s00345-018-2409-1

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  • DOI: https://doi.org/10.1007/s00345-018-2409-1

Keywords

  • Inflammation
  • Serenoa repens
  • Benign prostatic hyperplasia
  • Immunohistochemistry