Abstract
Objective
To evaluate differences in pathological features and prognostics across four bladder cancer histopathological types: urothelial carcinoma (UC), urothelial carcinoma with variant histology (UCV), squamous cell carcinoma (SCC) and adenocarcinoma (ADC), utilizing a large cohort of radical cystectomy (RC) patients.
Methods
A retrospective analysis of patients who underwent RC at a single institution in Egypt between 1997 and 2004 was performed. Kaplan–Meier and multivariable analyses were performed to evaluate the prognostic significance of pathological features including tumor stage, grade, lymphovascular invasion (LVI), and lymph node (LN) involvement in the different subtypes on disease-free survival (DFS).
Results
1238 patients (975 male, 263 female) were included, of whom 577 (47%) had UC, 174 (14%) UCV, 398 (32%) SCC, and 89 (7%) ADC. Median age was 54 (20–87) years and median follow-up was 40 months (0–110). There were significant differences in stage, grade, LVI, LN involvement, and presence of schistosomiasis across the subtypes (all p < 0.05). The prognostic significance of LVI was more evident in SCC (HR 2.14, p = 0.003) and ADC (HR 2.17, p = 0.044) than in UC (HR 1.66, p = 0.008). LN involvement was the strongest prognostic factor in UCV (HR 2.14, p = 0.012).
Conclusions
There are significant differences in clinicopathological features and their prognostic impact across bladder cancer subtypes. The prognostic significance of LVI is more evident in SCC and ADC, while LN involvement is more prognostic in UCV. Determining independent predictors in individual subtypes can guide multimodal treatment selection and clinical trial design.
Similar content being viewed by others
Abbreviations
- UC:
-
Urothelial carcinoma
- UCV:
-
Urothelial carcinoma with variant histology
- SCC:
-
Squamous cell carcinoma
- ADC:
-
Adenocarcinoma
- RC:
-
Radical cystectomy
- DFS:
-
Disease-free survival
- LVI:
-
Lymphovascular invasion
- LN:
-
Lymph node
- SEER:
-
Surveillance, epidemiology, and end results
References
Siegel RL, Miller KD, Jemal A (2017) Cancer statistics, 2017. CA Cancer J Clin 67:7–30
Wasco MJ, Daignault S, Zhang Y, Kunju LP, Kinnaman M, Braun T, Lee CT, Shah RB (2007) Urothelial carcinoma with divergent histologic differentiation (mixed histologic features) predicts the presence of locally advanced bladder cancer when detected at transurethral resection. J Urol 70:69–74
Moschini M, Shariat SF, Luciano R, D’Andrea D, Foerster B, Abufaraj M et al (2017) Pure but not mixed histologic variants are associated with poor survival at radical cystectomy in bladder cancer patients. Clin Genitourin Cancer 15:e603–e607
El- Sebaie M, Zaghloul MA, Mokhtar A (2005) A squamous cell carcinoma of the bilharzial and non-bilharzial urinary bladder: a review of etiological features, natural history, and management. Int J Clin Oncol 10:20–25
Moschini M, D’Andrea D, Korn S, Irmak Y, Soria F, Comperat E et al (2017) Characteristics and clinical significance of histological variants of bladder cancer. Nat Rev Urol 14(11):651–668
Black PC, Brown GA, Dinney CPN (2009) The impact of variant histology on the outcome of bladder cancer treated with curative intent. Urol Oncol 27:3–7
Navon JD, Soliman H, Khonsari F, Ahlering T (1997) Screening cystoscopy and survival of spinal cord injured patients with squamous cell cancer of the bladder. J Urol 157:2109–2111
Novara G, Matsumoto K, Kassouf W, Walton TJ, Fritsche HM, Bastian PJ, Martinez-Salamanca JI, Seitz C, Lemberger RJ, Burger M et al (2010) Prognostic role of lymphovascular invasion in patients with urothelial carcinoma of the upper urinary tract: an international validation study. Eur Urol 57:1064–1071
Tarin TV, Power NE, Ehdaie B, Sfakianos JP, Silberstein JL, Savage CJ, Sjoberg D, Dalbagni G, Bochner BH (2012) Lymph node-positive bladder cancer treated with radical cystectomy and lymphadenectomy: effect of the level of node positivity. Eur Urol 61:1025–1030
Consortium BatIBCN (2006) Postoperative nomogram predicting risk of recurrence after radical cystectomy for bladder cancer. J Clin Oncol 24:3967–3972
Kim SP, Frank I, Cheville JC, Thompson RH, Weight CJ, Thapa P et al (2012) The impact of squamous and glandular differentiation on survival after radical cystectomy for urothelial carcinoma. J Urol 188:405–409
Rogers CG, Palapattu GS, Shariat SF et al (2006) Clinical outcomes following radical cystectomy for primary nontransitional cell carcinoma of the bladder compared to transitional cell carcinoma of the bladder. J Urol 175:2048–2053
Ghoneim MA, Abdel-Latif M, El-Mekresh M, Abol-Enein H, Mosbah A, Ashamallah A, El-Baz MA (2008) Radical cystectomy for carcinoma of the bladder: 2,720 consecutive cases 5 years later. J Urol 180:121–127
Moschini M, Dell’Oglio P, Luciano R, Gandaglia G, Soria F, Mattei A et al (2017) Incidence and effect of variant histology on oncological outcomes in patients with bladder cancer treated with radical cystectomy. Urol Oncol. 35:335–341
Xylinas E, Rink M, Robinson BD, Lotan Y, Babjuk M, Brisuda A, Green DA, Kluth LA, Pycha A, Fradet Y, Faison T, Lee RK, Karakiewicz PI, Zerbib M, Scherr DS, Shariat SF (2013) Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy. E J Cancer. 49:1889–1897
Monn MF, Kaimakliotis HZ, Pedrosa JA, Cary KC, Bihrle R, Cheng L et al (2015) Contemporary bladder cancer: variant histology may be a significant driver of disease. Urol Oncol. 33:18.e5–18.e20
Abdollah F, Sun M, Jeldres C, Schmitges J, Thuret R, Djahangirian O et al (2012) Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma: a competing-risks analysis. BJU Int. 109:564–569
Lughezzani G, Sun M, Jeldres C, Alasker A, Budaus L, Shariat SF et al (2010) Adenocarcinoma versus urothelial carcinoma of the urinary bladder: comparison between pathologic stage at radical cystectomy and cancer-specific mortality. Urology. 75:376–381
Scozyrev E, Yao J, Messing E (2009) Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? Urology 73:822–827
Bolenz C, Herrmann E, Bastian PJ, Michel MS, Wulfing C, Tiemann A, Buchner A, Stief CG, Fritsche HM, Burger M et al (2010) Lymphovascular invasion is an independent predictor of oncological outcomes in patients with lymph node-negative urothelial bladder cancer treated by radical cystectomy: a multicentre validation trial. BJU Int 106:493–499
Kim HS, Kim M, Jeong CW, Kwak C, Kim HH, Ku JH (2014) Presence of lymphovascular invasion in urothelial bladder cancer specimens after transurethral resections correlates with risk of upstaging and survival: a systematic review and meta-analysis. Urol Oncol. 32:1191–1199
Spradling K, Lotan Y, Shokeir A, Abol-Enein H, Mosbah A, Morgan JB et al (2016) Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder. Urol Oncol 34(9):417.e1–417.e8
Dutta R, Abdelhalim A, Martin JW, Vernez SL, Faltas B, Lotan Y et al (2016) Effect of tumor location on survival in urinary bladder adenocarcinoma: a population-based analysis. Urol Oncol 34:531.e1–531.e6
Ehdaie B, Maschino A, Shariat SF, Rioja J, Hamilton RJ, Lowrance WT, Poon SA, Al-Ahmadie HA, Herr HW (2012) Comparative outcomes of pure squamous cell carcinoma and urothelial carcinoma with squamous differentiation in patients treated with radical cystectomy. J Urol 187:74–79
Martin JW, Carballido EM, Ahmed A, Farhan B, Dutta R, Smith C et al (2016) Squamous cell carcinoma of the urinary bladder: systematic review of clinical characteristics and therapeutic approaches. Arab J Urol 14:183–191
Liu Y, Bui MM, Xu B (2017) Urothelial carcinoma with squamous differentiation is associated with high tumor stage and pelvic lymph-node metastasis. Cancer Control 24:78–82
Author information
Authors and Affiliations
Contributions
JWM: data analysis and manuscript writing/editing. SLV: data analysis and manuscript writing/editing. YL: manuscript writing/editing. AA: manuscript writing/editing. RD: manuscript writing/editing. AS: protocol/project development, data collection, or management. HA-E: protocol/project development, data collection, or management. AM: protocol/project development, data collection, or management. MG: protocol/project development, data collection or management. RFY: protocol/project development, data collection or management, data analysis, and manuscript writing/editing.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Human and/or animal rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Rights and permissions
About this article
Cite this article
Martin, J.W., Vernez, S.L., Lotan, Y. et al. Pathological characteristics and prognostic indicators of different histopathological types of urinary bladder cancer following radical cystectomy in a large single-center Egyptian cohort. World J Urol 36, 1835–1843 (2018). https://doi.org/10.1007/s00345-018-2331-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00345-018-2331-6