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World Journal of Urology

, Volume 36, Issue 2, pp 271–276 | Cite as

Safety and feasibility study of holmium laser enucleation of the prostate (HOLEP) on patients receiving dual antiplatelet therapy (DAPT)

  • Jie Sun
  • An Shi
  • Zhen Tong
  • Wei XueEmail author
Original Article

Abstract

Objective

To evaluate the safety and feasibility of Holmium laser enucleation of the prostate (HoLEP) in patients receiving dual antiplatelet therapy (DAPT).

Methods

From March 2013 to August 2016, we retrospectively analyzed 1124 benign prostatic hyperplasia (BPH) patients undergoing HoLEP and divided into four groups: 56 cases receiving DAPT therapy (group A); 72 patients treated with continuous single antiplatelet (AP) therapy (group B); 41 patients treated with single AP therapy but intermittent during preoperative time (group C) and 955 cases had no AP therapy (group D). Patients’ baseline characteristics, 1-year clinical outcomes, rates of postoperative bleeding and complications were presented in this study.

Results

All patients received successful operations and no severe postoperative complications occurred. Only one patient in Group D required transfusion. The enucleation time and catheterization time for the DAPT patients were the longest among four groups (p < 0.001, respectively). The overall complications rates within 30 days were 23.2% (13/56) in Group A, 27.8% (20/72) in Group B, 19.5% (8/41) in Group C, and 27.0% (258/955) in Group D, respectively (p = 0.678). By the 12 months, the international prostate symptom scores (IPSS), quality of life scores (QOL) and residual urine volume (RUV) in all groups have been significantly improved.

Conclusion

HoLEP in patients receiving DAPT after coronary artery stunting showed similar results to those achieved in patients receiving single AP therapy or non-AP therapy. It can be a good option, which the urologists can offer to those patients with symptomatic benign prostatic hyperplasia refractory to medical treatment.

Keywords

Benign prostate hyperplasia Lower urinary tract symptoms Holmium laser enucleation of the prostate Dual antiplatelet therapy 

Abbreviation

BPH

Benign prostatic hyperplasia

HoLEP

Holmium laser enucleation of the prostate

TURP

Transurethral resection of the prostate

PVP

Photoselective vaporization of the prostate

CABG

Coronary artery bypass grafts

DAPT

Dual antiplatelet treatment

PSA

Prostate-specific antigen

TRUS

Transrectal ultrasonography

PVR

Post-void residual urine

Notes

Acknowledgements

We gratefully acknowledge the urologists making great contributions to the prostatic laser surgery, especially YiRan Huang and Gilling PJ.

Authors’ contributions

SJ: Project development and manuscript writing. SA: Data collection and analysis, and manuscript writing. TZ: Data collection and management. XW: Project development and manuscript editing.

Funding

The authors declare that they have no funding.

Compliance with ethical standards

Ethics statement

Institutional Review Board approval of Renji Hospital affiliated to Shanghai JiaoTong University, Medical school was obtained for the retrospective study and patient written informed consent was obtained.

Consent to publish

All of the details can be published and consent for publication was not required for this study.

Availability of data and materials

The datasets during the current study were available from the corresponding author on reasonable request.

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of UrologyRenji Hospital affiliated to Shanghai Jiao Tong University, Medical SchoolShanghaiChina

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