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Dual energy can accurately differentiate uric acid-containing urinary calculi from calcium stones

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Abstract

Purpose

To retrospectively evaluate the accuracy of dual-energy CT (DECT) in the detection of the chemical composition of urinary calculi in correlation with infrared spectroscopic stone analysis.

Methods

We reviewed the CT scans of 255 patients who underwent DECT due to a clinical suspicion of urolithiasis. Out of this group, we included 64 patients with clinically symptomatic urolithiasis requiring stone removal. After surgical removal of the stone by ureterorenoscopy, chemical composition was analyzed with infrared spectroscopy. We correlated DECT stone characterization results with chemical stone composition based on dual-energy indices (DEI). A total of 213 renal and ureteral stones could be removed and chemically analyzed.

Results

A total of 213 calculi were evaluated. Thirty eight out of sixty four (59 %) patients had >1 stone. DECT was used to differentiate stones by using DEI. Stones harboring calcium (CA) were color-coded in blue, while stones containing uric acid (UA) were colored red. Median DEI in UA-containing stones were 0.001. Non-UA-containing stones had a DEI between 0.073 for pure CA stones and 0.077 containing CA and other substances (p = 0.001; p = 0.03, respectively). Sensitivity of DECT was 98.4 % for differentiation of UA from non-UA-containing calculi. Specificity was 98.1 %. Mean effective radiation dose of DECT was 4.18 mSv (0.44–14.27 mSv), thus comparable to conventional CT scans of the abdomen. Conventional measurement of Hounsfield units did not correlate with stone composition.

Conclusion

DECT with image post-processing reliably discriminates UA-containing calculi from all other stones, but the study offered limitations. Discrimination within the non-UA stones cannot be reliably achieved but is clinically insignificant.

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Author’s contribution

A. Spek wrote the manuscript and was involved in project development and data management; F. Strittmatter was involved in data collection and data management; A. Graser was involved in data collection and edited the manuscript; P. Kufer was involved in data collection and analysis; C. Stief was involved in project development; M. Staehler edited the manuscript.

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Authors and Affiliations

  1. Department of Urology, University Hospitals Munich, Campus Grosshadern, Munich, Germany

    A. Spek, F. Strittmatter, P. Kufer, C. Stief & M. Staehler

  2. Department of Radiology, University Hospitals Munich, Campus Grosshadern, Munich, Germany

    A. Graser

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  1. A. Spek
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  2. F. Strittmatter
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  3. A. Graser
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  4. P. Kufer
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Correspondence to A. Spek.

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The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Spek, A., Strittmatter, F., Graser, A. et al. Dual energy can accurately differentiate uric acid-containing urinary calculi from calcium stones. World J Urol 34, 1297–1302 (2016). https://doi.org/10.1007/s00345-015-1756-4

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  • DOI: https://doi.org/10.1007/s00345-015-1756-4

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